SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ywr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		4 / 4 SER A 190
LEU A 150
TYR A 192
GLY A 178
 None
 1.37A 1liiA-4ywrA:
15.5		 1liiA-4ywrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		5 / 8 THR A 144
PRO A 145
VAL A 174
ALA A 140
PRO A 113
 None
 1.43A 2v32A-4ywrA:
undetectable
2v32B-4ywrA:
undetectable		 2v32A-4ywrA:
23.78
2v32B-4ywrA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		5 / 8 PRO A 113
THR A 144
PRO A 145
VAL A 174
ALA A 140
 None
 1.39A 2v32A-4ywrA:
undetectable
2v32B-4ywrA:
undetectable		 2v32A-4ywrA:
23.78
2v32B-4ywrA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		5 / 9 THR A 144
PRO A 145
VAL A 174
ALA A 140
PRO A 113
 None
 1.43A 2v41A-4ywrA:
undetectable
2v41B-4ywrA:
undetectable		 2v41A-4ywrA:
23.78
2v41B-4ywrA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		5 / 9 PRO A 113
THR A 144
PRO A 145
VAL A 174
ALA A 140
 None
 1.42A 2v41A-4ywrA:
undetectable
2v41B-4ywrA:
undetectable		 2v41A-4ywrA:
23.78
2v41B-4ywrA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		6 / 11 GLY A  18
ASP A  20
ALA A  25
GLY A  26
MET A  87
VAL A 114
 PLP  A 300 ( 4.1A)
PLP  A 300 ( 4.8A)
PLP  A 300 (-2.9A)
PLP  A 300 (-3.4A)
PLP  A 300 ( 3.7A)
PLP  A 300 ( 4.8A)
 0.36A 4c5lA-4ywrA:
26.5		 4c5lA-4ywrA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		6 / 9 GLY A  18
ASP A  20
ALA A  25
GLY A  26
MET A  87
VAL A 114
 PLP  A 300 ( 4.1A)
PLP  A 300 ( 4.8A)
PLP  A 300 (-2.9A)
PLP  A 300 (-3.4A)
PLP  A 300 ( 3.7A)
PLP  A 300 ( 4.8A)
 0.27A 4c5lB-4ywrA:
25.9		 4c5lB-4ywrA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		6 / 10 GLY A  18
ASP A  20
ALA A  25
GLY A  26
MET A  87
VAL A 114
 PLP  A 300 ( 4.1A)
PLP  A 300 ( 4.8A)
PLP  A 300 (-2.9A)
PLP  A 300 (-3.4A)
PLP  A 300 ( 3.7A)
PLP  A 300 ( 4.8A)
 0.30A 4c5lC-4ywrA:
26.8		 4c5lC-4ywrA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		6 / 10 GLY A  18
ASP A  20
ALA A  25
GLY A  26
MET A  87
VAL A 114
 PLP  A 300 ( 4.1A)
PLP  A 300 ( 4.8A)
PLP  A 300 (-2.9A)
PLP  A 300 (-3.4A)
PLP  A 300 ( 3.7A)
PLP  A 300 ( 4.8A)
 0.30A 4c5lD-4ywrA:
26.6		 4c5lD-4ywrA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		4 / 7 GLY A  18
ASP A  20
GLY A  26
MET A  87
 PLP  A 300 ( 4.1A)
PLP  A 300 ( 4.8A)
PLP  A 300 (-3.4A)
PLP  A 300 ( 3.7A)
 0.26A 4c5nA-4ywrA:
25.6		 4c5nA-4ywrA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		6 / 10 GLY A  18
ASP A  20
ALA A  25
GLY A  26
MET A  87
VAL A 114
 PLP  A 300 ( 4.1A)
PLP  A 300 ( 4.8A)
PLP  A 300 (-2.9A)
PLP  A 300 (-3.4A)
PLP  A 300 ( 3.7A)
PLP  A 300 ( 4.8A)
 0.26A 4c5nB-4ywrA:
26.2		 4c5nB-4ywrA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		5 / 8 GLY A  18
ASP A  20
GLY A  26
MET A  87
VAL A 114
 PLP  A 300 ( 4.1A)
PLP  A 300 ( 4.8A)
PLP  A 300 (-3.4A)
PLP  A 300 ( 3.7A)
PLP  A 300 ( 4.8A)
 0.32A 4c5nC-4ywrA:
25.6		 4c5nC-4ywrA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		6 / 10 GLY A  18
ASP A  20
ALA A  25
GLY A  26
MET A  87
VAL A 114
 PLP  A 300 ( 4.1A)
PLP  A 300 ( 4.8A)
PLP  A 300 (-2.9A)
PLP  A 300 (-3.4A)
PLP  A 300 ( 3.7A)
PLP  A 300 ( 4.8A)
 0.38A 4c5nD-4ywrA:
26.2		 4c5nD-4ywrA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		5 / 11 THR A  46
ALA A  47
PHE A  59
PHE A 133
ILE A  94
 None
 1.13A 4claA-4ywrA:
undetectable		 4claA-4ywrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		5 / 9 LYS A  84
LEU A 111
LEU A 136
LEU A 101
ALA A  98
 PLP  A 300 ( 4.3A)
None
None
None
None
 1.04A 5dqfA-4ywrA:
undetectable		 5dqfA-4ywrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		5 / 12 ASP A 182
GLY A 178
ASN A 146
LEU A 150
ALA A 162
 None
 1.12A 5kc4E-4ywrA:
undetectable		 5kc4E-4ywrA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		4 / 5 VAL A 110
ASP A 112
PRO A 113
ALA A 218
 None
PLP  A 300 (-3.1A)
None
None
 1.09A 5otrA-4ywrA:
undetectable		 5otrA-4ywrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE
(Acinetobacter
baumannii) 		3 / 3 VAL A  83
TYR A 107
GLN A 108
 None
 0.75A 5qgrA-4ywrA:
undetectable		 5qgrA-4ywrA:
22.80