SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 4yx8 DSBA-LIKE PROTEIN
(Proteus
mirabilis) 		4 / 7 ASP A  81
PHE A 113
TYR A  82
PRO A 112
 None
 1.46A 2q6kA-4yx8A:
undetectable		 2q6kA-4yx8A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4yx8 DSBA-LIKE PROTEIN
(Proteus
mirabilis) 		4 / 6 TYR A  82
MET A 159
ILE A 167
LEU A 169
 None
 1.31A 2wekB-4yx8A:
undetectable		 2wekB-4yx8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 4yx8 DSBA-LIKE PROTEIN
(Proteus
mirabilis) 		5 / 12 VAL A 128
ALA A  63
THR A 162
ILE A 155
THR A 164
 None
 1.21A 3dl9B-4yx8A:
undetectable		 3dl9B-4yx8A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 4yx8 DSBA-LIKE PROTEIN
(Proteus
mirabilis) 		4 / 5 PRO A 110
SER A  78
LEU A 181
SER A 184
 None
 1.37A 3iluH-4yx8A:
undetectable		 3iluH-4yx8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4yx8 DSBA-LIKE PROTEIN
(Proteus
mirabilis) 		5 / 9 ILE A 201
LEU A  93
VAL A 106
LEU A  76
ILE A  97
 None
 1.26A 4r38C-4yx8A:
undetectable		 4r38C-4yx8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4yx8 DSBA-LIKE PROTEIN
(Proteus
mirabilis) 		4 / 7 LEU A  58
ASN A 180
LEU A 183
LEU A 187
 None
 0.81A 4wg0B-4yx8A:
undetectable
4wg0C-4yx8A:
undetectable		 4wg0B-4yx8A:
5.95
4wg0C-4yx8A:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4yx8 DSBA-LIKE PROTEIN
(Proteus
mirabilis) 		4 / 7 ASN A 180
LEU A 183
LEU A 187
LEU A  58
 None
 0.80A 4wg0L-4yx8A:
undetectable
4wg0M-4yx8A:
undetectable		 4wg0L-4yx8A:
5.95
4wg0M-4yx8A:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4yx8 DSBA-LIKE PROTEIN
(Proteus
mirabilis) 		5 / 12 ILE A 108
LEU A 143
GLY A  68
PHE A 136
THR A  98
 None
 1.14A 5byjA-4yx8A:
undetectable		 5byjA-4yx8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4yx8 DSBA-LIKE PROTEIN
(Proteus
mirabilis) 		4 / 4 CYH A  87
PHE A  90
ILE A 189
GLY A 204
 None
 1.29A 5hesB-4yx8A:
undetectable		 5hesB-4yx8A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4yx8 DSBA-LIKE PROTEIN
(Proteus
mirabilis) 		5 / 12 LEU A 187
ILE A 201
GLN A 218
ILE A  97
LEU A  94
 None
 1.02A 5y2tB-4yx8A:
undetectable		 5y2tB-4yx8A:
undetectable