SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yxc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 4yxc FLAGELLAR MOTOR
SWITCH PROTEIN
FLIM,FLAGELLAR MOTOR
SWITCH PROTEIN FLIN
(Salmonella
enterica) 		4 / 6 HIS B  79
LEU B  62
LEU B  80
PRO B  83
 None
 1.06A 1hz4A-4yxcB:
undetectable		 1hz4A-4yxcB:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
(Escherichia
virus
T4;
Salmonella
enterica) 		5 / 11 LEU A 105
GLU A 129
GLY A  98
ILE A 121
LEU A 154
 None
 1.12A 1p91A-4yxcA:
undetectable		 1p91A-4yxcA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
(Escherichia
virus
T4;
Salmonella
enterica) 		5 / 12 ALA A 150
PHE A 174
LEU A 154
ALA A 151
ILE A  99
 None
 0.98A 2aclA-4yxcA:
undetectable
2aclE-4yxcA:
undetectable		 2aclA-4yxcA:
22.31
2aclE-4yxcA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4yxc FLAGELLAR MOTOR
SWITCH PROTEIN
FLIM,FLAGELLAR MOTOR
SWITCH PROTEIN FLIN
(Salmonella
enterica) 		5 / 11 ALA B  23
LEU B  80
LEU B 171
LEU B  21
LEU B  62
 None
 1.12A 2ceoA-4yxcB:
undetectable		 2ceoA-4yxcB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
(Escherichia
virus
T4;
Salmonella
enterica) 		4 / 6 PHE A 174
VAL A 108
LEU A 139
ALA A 150
 None
 1.00A 2e1qA-4yxcA:
undetectable		 2e1qA-4yxcA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
(Escherichia
virus
T4;
Salmonella
enterica) 		4 / 6 PHE A 174
VAL A 108
LEU A 139
ALA A 150
 None
 1.00A 2e1qC-4yxcA:
undetectable		 2e1qC-4yxcA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4yxc FLAGELLAR MOTOR
SWITCH PROTEIN
FLIM,FLAGELLAR MOTOR
SWITCH PROTEIN FLIN
(Salmonella
enterica) 		5 / 10 ALA B  23
LEU B  80
LEU B 171
LEU B  21
LEU B  62
 None
 1.19A 2riwA-4yxcB:
undetectable
2riwB-4yxcB:
undetectable		 2riwA-4yxcB:
20.35
2riwB-4yxcB:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
(Escherichia
virus
T4;
Salmonella
enterica) 		5 / 12 LEU A  36
PHE A  88
ASP A  93
VAL A  92
PHE A  25
 None
 1.22A 2zzmA-4yxcA:
undetectable		 2zzmA-4yxcA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
(Escherichia
virus
T4;
Salmonella
enterica) 		5 / 11 ALA A 150
PHE A 174
LEU A 154
ALA A 151
ILE A  99
 None
 1.01A 3fc6A-4yxcA:
undetectable		 3fc6A-4yxcA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
(Escherichia
virus
T4;
Salmonella
enterica) 		4 / 5 VAL A 170
ILE A  24
PHE A  25
PHE A  88
 None
 1.10A 3owxB-4yxcA:
undetectable		 3owxB-4yxcA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
(Escherichia
virus
T4;
Salmonella
enterica) 		4 / 7 PHE A 174
VAL A 108
LEU A 139
ALA A 150
 None
 1.00A 3uniA-4yxcA:
undetectable		 3uniA-4yxcA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
(Escherichia
virus
T4;
Salmonella
enterica) 		4 / 8 SER A  59
LYS A  37
VAL A  78
GLY A  77
 None
 0.94A 4klrB-4yxcA:
undetectable		 4klrB-4yxcA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
FLAGELLAR MOTOR
SWITCH PROTEIN
FLIM,FLAGELLAR MOTOR
SWITCH PROTEIN FLIN
(Escherichia
virus
T4;
Salmonella
enterica) 		5 / 12 THR B  68
TYR B  66
ASP A  17
ASP A  18
GLY B  71
 None
 1.38A 4qb9E-4yxcB:
undetectable		 4qb9E-4yxcB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4yxc FLAGELLAR MOTOR
SWITCH PROTEIN
FLIM,FLAGELLAR MOTOR
SWITCH PROTEIN FLIN
(Salmonella
enterica) 		3 / 3 MET B 163
GLU B 167
LEU B 171
 None
 0.70A 4v2oB-4yxcB:
undetectable		 4v2oB-4yxcB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
(Escherichia
virus
T4;
Salmonella
enterica) 		4 / 7 THR A  47
TYR A  39
GLU A  32
HIS A  52
 None
 1.05A 5ecnA-4yxcA:
undetectable		 5ecnA-4yxcA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
FLAGELLAR MOTOR
SWITCH PROTEIN
FLIM,FLAGELLAR MOTOR
SWITCH PROTEIN FLIN
(Escherichia
virus
T4;
Salmonella
enterica) 		5 / 12 LEU B  62
LEU B  21
ARG B  51
GLY B  67
LEU A  19
 None
 1.17A 6b0lB-4yxcB:
undetectable		 6b0lB-4yxcB:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
FLAGELLAR MOTOR
SWITCH PROTEIN
FLIM,FLAGELLAR MOTOR
SWITCH PROTEIN FLIN
(Escherichia
virus
T4;
Salmonella
enterica;
Salmonella
enterica) 		4 / 4 LEU B 179
ASP B 180
GLN B  72
VAL A  92
 None
 1.46A 6bzoF-4yxcB:
undetectable		 6bzoF-4yxcB:
18.13