SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)
4yxd SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
CYTOCHROME B SMALL
SUBUNIT,
MITOCHONDRIAL

(Sus
scrofa;
Sus
scrofa)
5 / 12 PHE D 119
GLY D 115
ILE D 126
THR D 112
PHE C  70
None
1.49A 3a25A-4yxdD:
undetectable
3a25A-4yxdD:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)
4yxd SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
CYTOCHROME B SMALL
SUBUNIT,
MITOCHONDRIAL

(Sus
scrofa)
4 / 5 ASN D 120
PHE D 119
GLY D 115
TYR D 118
None
1.17A 3bcrA-4yxdD:
undetectable
3bcrA-4yxdD:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)
4yxd SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL

(Sus
scrofa)
4 / 8 MET C  39
SER C  42
ILE C  43
ARG C  46
FTN  C 302 (-3.3A)
FTN  C 302 (-3.0A)
None
FTN  C 302 ( 3.6A)
0.81A 3sfeB-4yxdC:
undetectable
3sfeC-4yxdC:
16.6
3sfeB-4yxdC:
19.85
3sfeC-4yxdC:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)
4yxd SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
CYTOCHROME B SMALL
SUBUNIT,
MITOCHONDRIAL

(Sus
scrofa)
4 / 8 LEU D  78
LEU D  53
VAL C  56
SER C  53
None
HEM  C 301 ( 4.6A)
HEM  C 301 (-4.6A)
HEM  C 301 (-3.4A)
1.05A 4qknA-4yxdD:
undetectable
4qknA-4yxdD:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4yxd SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
CYTOCHROME B SMALL
SUBUNIT,
MITOCHONDRIAL

(Sus
scrofa)
5 / 10 THR D  77
ALA D 110
ALA D 107
GLY D 115
ALA D 114
None
1.05A 4qw1Y-4yxdD:
undetectable
4qw1Z-4yxdD:
undetectable
4qw1Y-4yxdD:
24.88
4qw1Z-4yxdD:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)
4yxd SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
CYTOCHROME B SMALL
SUBUNIT,
MITOCHONDRIAL

(Sus
scrofa;
Sus
scrofa)
5 / 12 HIS C 101
GLY C  49
HIS C  45
GLY D  83
LEU C  52
HEM  C 301 (-3.4A)
HEM  C 301 (-3.6A)
HEM  C 301 (-4.7A)
HEM  C 301 (-3.3A)
HEM  C 301 (-4.1A)
1.12A 5hg0B-4yxdC:
undetectable
5hg0B-4yxdC:
22.30