SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yxm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 9 ALA A 301
ILE A 321
GLY A 308
ILE A 307
ILE A 343
 None
 0.92A 1hshB-4yxmA:
undetectable		 1hshB-4yxmA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		3 / 3 ASP A  62
ASP A  60
LYS A  67
 None
 1.17A 1lqtB-4yxmA:
undetectable		 1lqtB-4yxmA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 9 LEU A 329
GLU A 327
ILE A 335
GLY A 336
SER A 325
 None
 0.80A 2qmmA-4yxmA:
undetectable		 2qmmA-4yxmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 11 LEU A 329
GLU A 327
ILE A 335
GLY A 336
SER A 325
 None
 0.84A 2qmmA-4yxmA:
undetectable
2qmmB-4yxmA:
undetectable		 2qmmA-4yxmA:
20.88
2qmmB-4yxmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		4 / 6 SER A 134
LYS A 141
GLU A 113
TYR A 136
 None
 1.17A 2x7hA-4yxmA:
undetectable		 2x7hA-4yxmA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 12 ILE A 133
ALA A  38
LEU A  68
LYS A  26
ILE A  84
 None
 1.25A 2zzaA-4yxmA:
undetectable		 2zzaA-4yxmA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		4 / 7 ASP A 319
SER A 322
SER A 348
LYS A 351
 None
 1.33A 3bc9A-4yxmA:
undetectable		 3bc9A-4yxmA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		6 / 10 LEU A  71
GLY A  76
ALA A  77
VAL A  79
ILE A  53
GLY A  55
 None
 1.14A 3ekpD-4yxmA:
undetectable		 3ekpD-4yxmA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 12 GLN A 146
LEU A  24
GLY A  37
ALA A  38
SER A  72
 None
 1.11A 3kk6A-4yxmA:
undetectable		 3kk6A-4yxmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		6 / 12 GLN A 146
LEU A  24
VAL A 126
GLY A  37
ALA A  38
SER A  72
 None
 1.24A 3ln1A-4yxmA:
undetectable		 3ln1A-4yxmA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		6 / 12 GLN A 146
LEU A  24
VAL A 126
GLY A  37
ALA A  38
SER A  72
 None
 1.25A 3ln1B-4yxmA:
undetectable		 3ln1B-4yxmA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 12 LEU A  24
VAL A 126
GLY A  37
ALA A  38
SER A  72
 None
 1.09A 3pghD-4yxmA:
undetectable		 3pghD-4yxmA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		4 / 6 GLY A  21
THR A  22
LEU A  24
ASP A  29
 None
 1.01A 3ps9A-4yxmA:
undetectable		 3ps9A-4yxmA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		4 / 8 GLU A 176
GLU A 179
LEU A 234
PHE A 168
 None
 1.14A 3rqwF-4yxmA:
2.4
3rqwJ-4yxmA:
3.0		 3rqwF-4yxmA:
20.05
3rqwJ-4yxmA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 12 LEU A  24
VAL A 126
GLY A  37
ALA A  38
SER A  72
 None
 1.07A 3rr3A-4yxmA:
undetectable		 3rr3A-4yxmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 12 LEU A  24
VAL A 126
GLY A  37
ALA A  38
SER A  72
 None
 1.07A 3rr3B-4yxmA:
undetectable		 3rr3B-4yxmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 12 LEU A  24
VAL A 126
GLY A  37
ALA A  38
SER A  72
 None
 1.07A 3rr3C-4yxmA:
undetectable		 3rr3C-4yxmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 12 LEU A  24
VAL A 126
GLY A  37
ALA A  38
SER A  72
 None
 1.06A 3rr3D-4yxmA:
undetectable		 3rr3D-4yxmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 12 LEU A  80
ILE A  18
ILE A  78
ILE A 124
ALA A  27
 None
 0.94A 3uj7A-4yxmA:
undetectable		 3uj7A-4yxmA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 12 LEU A  80
ILE A  18
ILE A  78
ILE A 124
ALA A  27
 None
 0.95A 3uj7B-4yxmA:
undetectable		 3uj7B-4yxmA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 9 PRO A 304
ILE A 303
ARG A 339
GLY A 334
SER A 306
 None
 1.40A 4a3uA-4yxmA:
undetectable		 4a3uA-4yxmA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 7 PRO A 304
ILE A 303
ARG A 339
GLY A 334
SER A 306
 None
 1.48A 4a3uB-4yxmA:
undetectable		 4a3uB-4yxmA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		6 / 12 ILE A 133
ALA A  38
LEU A  68
LYS A  26
ILE A  84
ILE A  18
 None
 1.41A 4p3rA-4yxmA:
undetectable		 4p3rA-4yxmA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		4 / 7 ASN A  75
TYR A  69
LEU A  68
PHE A  63
 None
 1.21A 4yv5A-4yxmA:
undetectable		 4yv5A-4yxmA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		4 / 7 ASN A  75
TYR A  69
LEU A  68
PHE A  63
 None
 1.23A 4yv5B-4yxmA:
undetectable		 4yv5B-4yxmA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		5 / 12 LEU A  24
VAL A 126
GLY A  37
ALA A  38
SER A  72
 None
 1.05A 5jvzA-4yxmA:
undetectable		 5jvzA-4yxmA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		6 / 12 GLN A 146
LEU A  24
VAL A 126
GLY A  37
ALA A  38
SER A  72
 None
 1.19A 5jw1A-4yxmA:
undetectable		 5jw1A-4yxmA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		4 / 6 ARG A 207
LEU A 224
ARG A 221
ARG A 225
 None
 1.22A 5l6eA-4yxmA:
undetectable
5l6eB-4yxmA:
undetectable		 5l6eA-4yxmA:
20.31
5l6eB-4yxmA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA
(Thermotoga
maritima) 		3 / 3 LYS A 195
LEU A 171
ARG A 191
 None
 0.90A 5yw0A-4yxmA:
undetectable		 5yw0A-4yxmA:
21.36