SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		4 / 6 ARG A 403
ILE A 394
PHE A 405
GLU A 389
 None
 1.50A 1nsiA-4yxtA:
undetectable
1nsiB-4yxtA:
undetectable		 1nsiA-4yxtA:
22.34
1nsiB-4yxtA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		5 / 12 THR A 340
PHE A 184
VAL A 177
PHE A 121
ALA A   4
 None
 1.32A 1q23A-4yxtA:
undetectable
1q23B-4yxtA:
undetectable		 1q23A-4yxtA:
19.24
1q23B-4yxtA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		3 / 3 PRO A 286
GLY A 313
TYR A 246
 None
 0.73A 2vouA-4yxtA:
undetectable		 2vouA-4yxtA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		3 / 3 PRO A 286
GLY A 313
TYR A 246
 None
 0.69A 2vouB-4yxtA:
undetectable		 2vouB-4yxtA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		3 / 3 PRO A 286
GLY A 313
TYR A 246
 None
 0.70A 2vouC-4yxtA:
undetectable		 2vouC-4yxtA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		3 / 3 PHE A  54
ASN A  57
PHE A 405
 None
 1.03A 2zbuD-4yxtA:
undetectable		 2zbuD-4yxtA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		4 / 5 TYR A  94
ARG A 414
THR A  53
LEU A 404
 None
 1.39A 3ag4J-4yxtA:
undetectable		 3ag4J-4yxtA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		5 / 12 ALA A 248
PHE A 303
LEU A 306
ALA A 305
VAL A 125
 None
 1.11A 3dzyA-4yxtA:
undetectable		 3dzyA-4yxtA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		3 / 3 ALA A 305
THR A 309
CYH A 323
 None
 0.70A 3e4eB-4yxtA:
undetectable		 3e4eB-4yxtA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		5 / 12 PHE A  54
GLY A  14
ILE A  62
GLY A  55
ALA A 172
 None
 0.98A 3sudB-4yxtA:
undetectable		 3sudB-4yxtA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		5 / 9 ALA A 307
GLY A 287
LEU A 302
LEU A 288
ASN A 289
 None
 1.12A 3wdmC-4yxtA:
undetectable		 3wdmC-4yxtA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		3 / 3 HIS A 261
GLY A 275
ILE A 276
 None
 0.64A 4k50A-4yxtA:
undetectable		 4k50A-4yxtA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		3 / 3 HIS A 261
GLY A 275
ILE A 276
 None
 0.64A 4k50I-4yxtA:
undetectable		 4k50I-4yxtA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		5 / 12 LEU A 229
ALA A 260
LYS A 267
TYR A 240
GLY A 237
 None
 1.06A 4l9qA-4yxtA:
undetectable		 4l9qA-4yxtA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		4 / 8 ASN A 296
PRO A 252
MET A 298
PHE A 253
 None
 1.09A 4v2zB-4yxtA:
undetectable		 4v2zB-4yxtA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		4 / 8 ASN A 296
PRO A 252
MET A 298
PHE A 253
 None
 1.23A 4v30B-4yxtA:
undetectable		 4v30B-4yxtA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		4 / 5 TYR A 335
GLY A 120
TYR A 115
GLY A 327
 None
 0.88A 5ayfA-4yxtA:
undetectable		 5ayfA-4yxtA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		4 / 6 SER A 332
GLY A 337
ASP A 187
GLY A 322
 None
 0.88A 5cdnC-4yxtA:
undetectable
5cdnD-4yxtA:
undetectable		 5cdnC-4yxtA:
24.00
5cdnD-4yxtA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		4 / 6 ILE A 394
VAL A  44
PRO A  47
ALA A  16
 None
 0.85A 5cu6A-4yxtA:
undetectable		 5cu6A-4yxtA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		5 / 12 LEU A 302
TYR A 115
PHE A 303
ILE A  78
PHE A 334
 None
 1.04A 5fsaB-4yxtA:
undetectable		 5fsaB-4yxtA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		4 / 5 TYR A 367
VAL A  44
PRO A  47
ALA A  16
 None
 0.97A 5otrA-4yxtA:
undetectable		 5otrA-4yxtA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		5 / 12 ALA A 300
ALA A 172
GLY A  13
GLY A 287
ALA A 248
 None
 0.99A 5w4zB-4yxtA:
undetectable		 5w4zB-4yxtA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		4 / 5 TYR A  94
ARG A 414
THR A  53
LEU A 404
 None
 1.31A 5x1bW-4yxtA:
undetectable		 5x1bW-4yxtA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG
(Bacillus
subtilis) 		3 / 3 ARG A 283
LEU A 247
PHE A 324
 None
 0.74A 6nknP-4yxtA:
undetectable		 6nknP-4yxtA:
21.41