SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4yxx DTOR_6X35L
(synthetic
construct) 		5 / 11 LEU A   3
ALA A 163
VAL A 199
LEU A 174
GLN A 180
 None
 1.39A 1kt7A-4yxxA:
undetectable		 1kt7A-4yxxA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4yxx DTOR_6X35L
(synthetic
construct) 		5 / 12 LEU A 133
ALA A 132
LEU A 143
LYS A 116
ALA A 118
 None
 1.10A 1sa1A-4yxxA:
undetectable
1sa1B-4yxxA:
undetectable		 1sa1A-4yxxA:
19.96
1sa1B-4yxxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4yxx DTOR_6X35L
(synthetic
construct) 		5 / 12 LEU A 133
ALA A 132
LEU A 143
LYS A 116
ALA A 118
 None
 1.10A 1sa1C-4yxxA:
undetectable
1sa1D-4yxxA:
undetectable		 1sa1C-4yxxA:
19.96
1sa1D-4yxxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4yxx DTOR_6X35L
(synthetic
construct) 		4 / 6 LEU A 147
ALA A 118
LEU A 150
THR A 123
 None
 1.06A 2roxB-4yxxA:
undetectable		 2roxB-4yxxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 4yxx DTOR_6X35L
(synthetic
construct) 		4 / 6 LEU A   7
ALA A 188
LEU A  10
THR A 193
 None
 0.91A 3cfqA-4yxxA:
undetectable		 3cfqA-4yxxA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 4yxx DTOR_6X35L
(synthetic
construct) 		4 / 6 LEU A  77
ALA A  48
LEU A  80
THR A  53
 None
 0.95A 3cfqA-4yxxA:
undetectable		 3cfqA-4yxxA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4yxx DTOR_6X35L
(synthetic
construct) 		5 / 12 ALA A   6
LEU A   3
LEU A 174
ALA A 167
LEU A 185
 None
 1.31A 3ozuA-4yxxA:
undetectable		 3ozuA-4yxxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yxx DTOR_6X35L
(synthetic
construct) 		5 / 12 ILE A   9
ALA A  13
ALA A  23
LEU A  45
VAL A   1
 None
 1.13A 3uvvB-4yxxA:
undetectable		 3uvvB-4yxxA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4yxx DTOR_6X35L
(synthetic
construct) 		5 / 12 VAL A  47
LEU A  45
VAL A  55
ALA A  27
LEU A  34
 None
 1.12A 4i1rA-4yxxA:
undetectable		 4i1rA-4yxxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4yxx DTOR_6X35L
(synthetic
construct) 		5 / 12 VAL A 117
LEU A 115
VAL A 125
ALA A  97
LEU A 104
 None
 1.09A 4i1rA-4yxxA:
undetectable		 4i1rA-4yxxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4yxx DTOR_6X35L
(synthetic
construct) 		5 / 12 VAL A 152
LEU A 150
VAL A 160
ALA A 132
LEU A 139
 None
 1.07A 4i1rA-4yxxA:
undetectable		 4i1rA-4yxxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4yxx DTOR_6X35L
(synthetic
construct) 		4 / 6 LEU A   7
ALA A 188
LEU A  10
THR A 193
 None
 0.97A 4i89A-4yxxA:
undetectable		 4i89A-4yxxA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4yxx DTOR_6X35L
(synthetic
construct) 		4 / 6 LEU A  77
ALA A  48
LEU A  80
THR A  53
 None
 1.01A 4i89A-4yxxA:
undetectable		 4i89A-4yxxA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4yxx DTOR_6X35L
(synthetic
construct) 		4 / 6 LEU A 147
ALA A 118
LEU A 150
THR A 123
 None
 0.96A 4ikiB-4yxxA:
undetectable		 4ikiB-4yxxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4yxx DTOR_6X35L
(synthetic
construct) 		4 / 6 LEU A   7
ALA A 188
LEU A  10
THR A 193
 None
 0.99A 5l4iA-4yxxA:
undetectable		 5l4iA-4yxxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4yxx DTOR_6X35L
(synthetic
construct) 		4 / 6 LEU A  77
ALA A  48
LEU A  80
THR A  53
 None
 1.03A 5l4iA-4yxxA:
undetectable		 5l4iA-4yxxA:
25.00