SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yxz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4yxz DTOR_9X31L
(synthetic
construct) 		5 / 10 GLU A 229
LEU A 233
LEU A 261
ALA A 251
GLY A 255
 None
 1.41A 1cmcA-4yxzA:
undetectable
1cmcB-4yxzA:
undetectable		 1cmcA-4yxzA:
18.08
1cmcB-4yxzA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4yxz DTOR_9X31L
(synthetic
construct) 		5 / 10 GLU A 229
LEU A 233
LEU A 261
ALA A 251
GLY A 255
 None
 1.40A 1mjqC-4yxzA:
undetectable
1mjqD-4yxzA:
2.0		 1mjqC-4yxzA:
18.46
1mjqD-4yxzA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4yxz DTOR_9X31L
(synthetic
construct) 		4 / 4 ALA A  17
TYR A  21
ALA A 268
TYR A 269
 None
 1.31A 2wlkA-4yxzA:
undetectable
2wlkB-4yxzA:
undetectable		 2wlkA-4yxzA:
21.82
2wlkB-4yxzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 4yxz DTOR_9X31L
(synthetic
construct) 		4 / 6 THR A 150
VAL A 151
GLU A 122
SER A 116
 None
 1.11A 3b6rB-4yxzA:
undetectable		 3b6rB-4yxzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4yxz DTOR_9X31L
(synthetic
construct) 		4 / 6 TYR A  93
VAL A 103
THR A  88
THR A  87
 None
 1.06A 3tneA-4yxzA:
undetectable		 3tneA-4yxzA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4yxz DTOR_9X31L
(synthetic
construct) 		5 / 8 GLY A  24
TYR A  52
ALA A  48
SER A  23
GLU A  49
 None
 1.25A 3u9hA-4yxzA:
undetectable		 3u9hA-4yxzA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4yxz DTOR_9X31L
(synthetic
construct) 		5 / 8 GLY A  24
TYR A  52
ALA A  48
SER A  23
GLU A  49
 None
 1.21A 3u9hB-4yxzA:
undetectable		 3u9hB-4yxzA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4yxz DTOR_9X31L
(synthetic
construct) 		5 / 8 GLY A  24
TYR A  52
ALA A  48
SER A  23
GLU A  49
 None
 1.26A 4bjcA-4yxzA:
undetectable		 4bjcA-4yxzA:
22.26