SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yyc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 6 LEU A 313
PHE A 387
TYR A 140
VAL A 135
 None
 1.33A 1ibgH-4yycA:
undetectable		 1ibgH-4yycA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 6 VAL A 180
THR A 179
GLU A 182
PHE A 160
 None
 1.07A 1s8fB-4yycA:
1.9		 1s8fB-4yycA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 7 VAL A 270
SER A 272
ARG A 354
PHE A 353
 None
UNL  A 601 ( 4.7A)
UNL  A 601 ( 3.0A)
None
 1.13A 2f78B-4yycA:
undetectable		 2f78B-4yycA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 12 THR A 111
PHE A 314
LEU A 349
ALA A 310
VAL A 271
 None
 1.38A 2g72A-4yycA:
undetectable		 2g72A-4yycA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 6 LEU A 492
ASP A 159
ASP A 147
GLU A 158
 None
 1.19A 2j2pE-4yycA:
undetectable
2j2pF-4yycA:
undetectable		 2j2pE-4yycA:
17.07
2j2pF-4yycA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A 337
ALA A 286
THR A 290
GLU A  55
LEU A 345
 None
 1.15A 2v0mD-4yycA:
undetectable		 2v0mD-4yycA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 8 THR A 288
PRO A 282
VAL A 283
SER A 277
 None
 1.12A 2v41G-4yycA:
undetectable
2v41H-4yycA:
undetectable		 2v41G-4yycA:
18.86
2v41H-4yycA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 243
LEU A 389
ARG A 354
TYR A 262
THR A 254
 None
None
UNL  A 601 ( 3.0A)
None
None
 1.16A 2w3mB-4yycA:
undetectable		 2w3mB-4yycA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 6 ARG A 153
ILE A 157
ARG A 161
SER A 198
 None
 1.28A 3ckzA-4yycA:
undetectable		 3ckzA-4yycA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 7 ARG A 347
ALA A 343
MET A 379
ALA A 383
 None
 1.36A 3tx2A-4yycA:
undetectable		 3tx2A-4yycA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		3 / 3 SER A 401
PHE A 406
LYS A 405
 None
 0.55A 3u88A-4yycA:
undetectable		 3u88A-4yycA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 5 LEU A 359
ALA A 318
MET A 379
THR A 376
 None
 1.38A 3vasB-4yycA:
undetectable		 3vasB-4yycA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 11 GLN A 267
PHE A 228
ASN A 235
GLU A 124
ASN A 122
 None
 1.34A 4a6nA-4yycA:
undetectable		 4a6nA-4yycA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 6 ALA A 392
ALA A 170
PRO A 171
LEU A 413
 None
 1.09A 4dtzB-4yycA:
undetectable		 4dtzB-4yycA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 6 PHE A 317
ALA A 319
GLY A 397
LEU A 359
 UNL  A 601 ( 4.4A)
None
None
None
 1.01A 4dubA-4yycA:
undetectable		 4dubA-4yycA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 8 PHE A 251
PHE A  76
ALA A 301
LEU A  69
 None
 0.77A 4ejgB-4yycA:
undetectable		 4ejgB-4yycA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 7 PHE A 251
PHE A  76
ALA A 301
LEU A  69
 None
 0.85A 4ejgC-4yycA:
undetectable		 4ejgC-4yycA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 6 PHE A 251
PHE A  76
ALA A 301
LEU A  69
 None
 0.87A 4ejgD-4yycA:
undetectable		 4ejgD-4yycA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		5 / 11 THR A 376
GLY A 356
ARG A 354
PHE A 353
THR A 134
 None
None
UNL  A 601 ( 3.0A)
None
None
 1.24A 4xt7A-4yycA:
undetectable		 4xt7A-4yycA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 8 ASN A 241
PHE A 387
HIS A 119
THR A 303
 None
 1.24A 5hqaA-4yycA:
6.5		 5hqaA-4yycA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 6 PHE A 274
PRO A 273
ARG A 354
ILE A 275
 UNL  A 601 ( 4.8A)
None
UNL  A 601 ( 3.0A)
None
 1.42A 5ih0A-4yycA:
undetectable		 5ih0A-4yycA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 7 GLY A 178
PHE A 207
SER A 175
ARG A 191
 None
 1.03A 5n5dB-4yycA:
undetectable		 5n5dB-4yycA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		3 / 3 ARG A 354
PHE A 353
GLY A 315
 UNL  A 601 ( 3.0A)
None
None
 0.77A 6fgdA-4yycA:
undetectable		 6fgdA-4yycA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE
(Sinorhizobium
meliloti) 		4 / 6 THR A 134
GLY A 384
ARG A  45
ARG A 347
 None
 1.31A 6gtqB-4yycA:
undetectable
6gtqD-4yycA:
undetectable		 6gtqB-4yycA:
16.95
6gtqD-4yycA:
6.74