SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yyp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4yyp SCL-INTERRUPTING
LOCUS PROTEIN
SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		5 / 12 LEU A 902
GLN B 739
LEU A 917
THR A 900
PHE A 962
 None
None
None
CL  A1001 (-3.7A)
None
 1.44A 2oaxA-4yypA:
undetectable		 2oaxA-4yypA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yyp SCL-INTERRUPTING
LOCUS PROTEIN
SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 12 VAL A 907
LEU A 955
VAL A 923
GLY A 922
ALA A 921
LEU B 736
 None
 1.49A 3rr3A-4yypA:
undetectable		 3rr3A-4yypA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yyp SCL-INTERRUPTING
LOCUS PROTEIN
SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 12 VAL A 907
LEU A 955
VAL A 923
GLY A 922
ALA A 921
LEU B 736
 None
 1.50A 3rr3B-4yypA:
undetectable		 3rr3B-4yypA:
10.29