SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 4yyq FICIN ISOFORM A
(Ficus
carica) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 161
GLY A  67
 None
 1.08A 1stfE-4yyqA:
36.3
1stfI-4yyqA:
undetectable		 1stfE-4yyqA:
49.09
1stfI-4yyqA:
17.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 4yyq FICIN ISOFORM A
(Ficus
carica) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 160
ALA A 161
 None
 0.26A 1stfE-4yyqA:
36.3
1stfI-4yyqA:
undetectable		 1stfE-4yyqA:
49.09
1stfI-4yyqA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 4yyq FICIN ISOFORM A
(Ficus
carica) 		4 / 5 ILE A 165
ARG A 179
ARG A   8
ASP A   6
 None
 1.49A 2rhmD-4yyqA:
undetectable		 2rhmD-4yyqA:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 4yyq FICIN ISOFORM A
(Ficus
carica) 		4 / 7 GLN A  19
GLY A  23
HIS A 160
TRP A 182
 None
 0.41A 3ai8A-4yyqA:
26.6		 3ai8A-4yyqA:
31.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4yyq FICIN ISOFORM A
(Ficus
carica) 		5 / 9 LEU A 122
GLY A 166
VAL A 131
SER A 132
VAL A 133
 None
 1.20A 4qd3A-4yyqA:
undetectable		 4qd3A-4yyqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yyq FICIN ISOFORM A
(Ficus
carica) 		5 / 10 GLY A 206
VAL A 207
VAL A 135
MET A 192
LEU A 178
 None
 1.16A 4yb6A-4yyqA:
undetectable
4yb6E-4yyqA:
undetectable		 4yb6A-4yyqA:
22.29
4yb6E-4yyqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yyq FICIN ISOFORM A
(Ficus
carica) 		5 / 10 GLY A 206
VAL A 207
VAL A 135
MET A 192
LEU A 178
 None
 1.15A 4yb6B-4yyqA:
undetectable
4yb6C-4yyqA:
undetectable		 4yb6B-4yyqA:
22.29
4yb6C-4yyqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yyq FICIN ISOFORM A
(Ficus
carica) 		5 / 10 GLY A 206
VAL A 207
VAL A 135
MET A 192
LEU A 178
 None
 1.24A 4yb6C-4yyqA:
undetectable
4yb6F-4yyqA:
undetectable		 4yb6C-4yyqA:
22.29
4yb6F-4yyqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yyq FICIN ISOFORM A
(Ficus
carica) 		5 / 10 MET A 192
LEU A 178
GLY A 206
VAL A 207
VAL A 135
 None
 1.22A 4yb6A-4yyqA:
undetectable
4yb6D-4yyqA:
undetectable		 4yb6A-4yyqA:
22.29
4yb6D-4yyqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yyq FICIN ISOFORM A
(Ficus
carica) 		5 / 10 MET A 192
LEU A 178
GLY A 206
VAL A 207
VAL A 135
 None
 1.23A 4yb6D-4yyqA:
undetectable
4yb6E-4yyqA:
undetectable		 4yb6D-4yyqA:
22.29
4yb6E-4yyqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yyq FICIN ISOFORM A
(Ficus
carica) 		5 / 10 MET A 192
LEU A 178
GLY A 206
VAL A 207
VAL A 135
 None
 1.16A 4yb6B-4yyqA:
undetectable
4yb6F-4yyqA:
undetectable		 4yb6B-4yyqA:
22.29
4yb6F-4yyqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 4yyq FICIN ISOFORM A
(Ficus
carica) 		4 / 7 TYR A 111
ILE A  78
ILE A 108
ILE A  83
 None
 0.93A 5murB-4yyqA:
undetectable		 5murB-4yyqA:
18.09