SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 4yys FICIN ISOFORM B
(Ficus
carica) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 163
GLY A  67
 None
 1.13A 1stfE-4yysA:
35.9
1stfI-4yysA:
0.5		 1stfE-4yysA:
47.73
1stfI-4yysA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 4yys FICIN ISOFORM B
(Ficus
carica) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 162
ALA A 163
 None
 0.22A 1stfE-4yysA:
35.9
1stfI-4yysA:
0.5		 1stfE-4yysA:
47.73
1stfI-4yysA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 4yys FICIN ISOFORM B
(Ficus
carica) 		4 / 5 ILE A 167
ARG A 181
ARG A   8
ASP A   6
 None
 1.47A 2rhmD-4yysA:
undetectable		 2rhmD-4yysA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4yys FICIN ISOFORM B
(Ficus
carica) 		5 / 12 PRO A 132
ILE A 110
VAL A 107
PRO A  46
LEU A  48
 None
 1.14A 3a51B-4yysA:
undetectable		 3a51B-4yysA:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 4yys FICIN ISOFORM B
(Ficus
carica) 		4 / 7 GLN A  19
GLY A  23
HIS A 162
TRP A 184
 None
 0.39A 3ai8A-4yysA:
26.6		 3ai8A-4yysA:
31.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4yys FICIN ISOFORM B
(Ficus
carica) 		4 / 4 GLN A 131
PRO A 132
VAL A  33
GLU A  35
 None
 1.10A 3huoA-4yysA:
undetectable		 3huoA-4yysA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4yys FICIN ISOFORM B
(Ficus
carica) 		4 / 6 LEU A  48
ILE A 110
THR A  38
GLY A  36
 None
 1.03A 4l39A-4yysA:
undetectable		 4l39A-4yysA:
16.90