SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yyw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 4yyw FICIN ISOFORM D
(Ficus
carica) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 163
GLY A  67
 None
 1.21A 1stfE-4yywA:
35.9
1stfI-4yywA:
undetectable		 1stfE-4yywA:
46.36
1stfI-4yywA:
17.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 4yyw FICIN ISOFORM D
(Ficus
carica) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 162
ALA A 163
 None
 0.31A 1stfE-4yywA:
35.9
1stfI-4yywA:
undetectable		 1stfE-4yywA:
46.36
1stfI-4yywA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4yyw FICIN ISOFORM D
(Ficus
carica) 		5 / 12 PRO A 132
ILE A 110
VAL A 107
PRO A  46
LEU A  48
 None
 1.19A 3a51B-4yywA:
undetectable		 3a51B-4yywA:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 4yyw FICIN ISOFORM D
(Ficus
carica) 		4 / 7 GLN A  19
GLY A  23
HIS A 162
TRP A 184
 None
 0.42A 3ai8A-4yywA:
26.5		 3ai8A-4yywA:
31.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4yyw FICIN ISOFORM D
(Ficus
carica) 		4 / 4 GLN A 131
PRO A 132
VAL A  33
GLU A  35
 None
 1.14A 3huoA-4yywA:
undetectable		 3huoA-4yywA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4yyw FICIN ISOFORM D
(Ficus
carica) 		3 / 3 THR A 171
ASN A 176
GLU A   3
 None
 0.78A 3v4tA-4yywA:
undetectable
3v4tC-4yywA:
undetectable		 3v4tA-4yywA:
19.44
3v4tC-4yywA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4yyw FICIN ISOFORM D
(Ficus
carica) 		5 / 11 MET A 194
PHE A 152
ASN A 176
THR A 200
ALA A 201
 None
 1.38A 4dx7A-4yywA:
undetectable		 4dx7A-4yywA:
10.69