SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yze'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4yze HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR NEMR
(Escherichia
coli) 		5 / 12 LEU A  75
GLY A 144
ASN A 147
ILE A 194
ALA A 195
 None
 1.09A 3uwlD-4yzeA:
undetectable		 3uwlD-4yzeA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4yze HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR NEMR
(Escherichia
coli) 		4 / 6 TYR A  90
VAL A 133
ILE A 134
LEU A 141
 None
 0.97A 4l1wB-4yzeA:
undetectable		 4l1wB-4yzeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yze HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR NEMR
(Escherichia
coli) 		4 / 5 ALA A 165
TYR A 164
GLY A  28
LEU A 107
 None
 0.94A 5eslA-4yzeA:
undetectable		 5eslA-4yzeA:
16.02