SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yzf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 5 GLU A 758
TYR A 392
PRO A 391
ASP A 396
 None
 1.39A 1i7zB-4yzfA:
undetectable		 1i7zB-4yzfA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_C_COCC302_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 4 GLU A 758
TYR A 392
PRO A 391
ASP A 396
 None
 1.32A 1i7zD-4yzfA:
undetectable		 1i7zD-4yzfA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 4 PHE A 679
ASP A 705
PHE A 702
VAL A 513
 None
 1.31A 1w0fA-4yzfA:
0.0		 1w0fA-4yzfA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		5 / 12 THR A 581
PHE A 622
LEU A 619
ILE A 624
ALA A 786
 None
 1.23A 2g72B-4yzfA:
undetectable		 2g72B-4yzfA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 527
ILE A 803
SER A 799
TYR A 519
 None
 1.15A 2hc4A-4yzfA:
undetectable		 2hc4A-4yzfA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4yzf FAB FRAGMENT OF
IMMUNOGLOBULIN (IGG)
MOLECULE
(Mus
musculus) 		4 / 8 ILE E  84
SER E  72
TYR E  95
SER E  19
 None
 1.09A 2zw9B-4yzfE:
undetectable		 2zw9B-4yzfE:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		5 / 11 ILE A 864
LEU A 687
LEU A 680
ILE A 684
PRO A 868
 None
 1.32A 3a50B-4yzfA:
1.7		 3a50B-4yzfA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 4yzf FAB FRAGMENT OF
IMMUNOGLOBULIN (IGG)
MOLECULE
(Mus
musculus) 		3 / 3 PRO E   9
LEU E 119
ARG E  40
 None
 0.75A 3aqiB-4yzfE:
undetectable		 3aqiB-4yzfE:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 6 GLY A 763
ALA A 452
LEU A 459
PRO A 458
 None
 0.92A 3bgdA-4yzfA:
undetectable		 3bgdA-4yzfA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		5 / 9 VAL A 709
VAL A 710
GLY A 713
THR A 444
GLY A 448
 None
 0.95A 3bjwG-4yzfA:
undetectable		 3bjwG-4yzfA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		5 / 11 ALA A 767
VAL A 461
ILE A 412
ILE A 761
PRO A 458
 None
 0.94A 3ekxB-4yzfA:
undetectable		 3ekxB-4yzfA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		5 / 9 ALA A 767
VAL A 461
ILE A 412
ILE A 761
PRO A 458
 None
 0.90A 3el4B-4yzfA:
undetectable		 3el4B-4yzfA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4yzf FAB FRAGMENT OF
IMMUNOGLOBULIN (IGG)
MOLECULE
(Mus
musculus) 		3 / 3 PRO E  14
LEU E  12
GLN E  16
 None
 0.73A 3hznG-4yzfE:
undetectable
3hznH-4yzfE:
undetectable		 3hznG-4yzfE:
20.70
3hznH-4yzfE:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		3 / 3 THR A 685
LYS A 539
GLU A 681
 None
4KU  A1000 (-1.4A)
4KU  A1000 (-4.4A)
 0.88A 3ijdB-4yzfA:
undetectable		 3ijdB-4yzfA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 8 GLY A 714
ILE A 487
PHE A 478
PHE A 471
 None
 0.76A 3ko0B-4yzfA:
undetectable
3ko0J-4yzfA:
undetectable		 3ko0B-4yzfA:
8.35
3ko0J-4yzfA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 8 GLY A 714
ILE A 487
PHE A 478
PHE A 471
 None
 0.79A 3ko0K-4yzfA:
undetectable
3ko0S-4yzfA:
undetectable		 3ko0K-4yzfA:
8.35
3ko0S-4yzfA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 5 LEU A 677
SER A 725
LEU A 468
PRO A 467
 None
None
None
4KU  A1000 (-4.1A)
 1.15A 3onnA-4yzfA:
undetectable		 3onnA-4yzfA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		5 / 9 LEU A 724
ALA A 716
ILE A 498
GLY A 494
ILE A 493
 None
 1.10A 3u7sA-4yzfA:
undetectable		 3u7sA-4yzfA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 5 GLY A 802
ILE A 803
VAL A 732
SER A 525
 None
 1.24A 4d33B-4yzfA:
undetectable		 4d33B-4yzfA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 859
LEU A 863
SER A 517
LEU A 677
ILE A 528
 None
 1.21A 4dm8A-4yzfA:
undetectable		 4dm8A-4yzfA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		6 / 12 GLY A 711
GLY A 714
GLY A 713
LEU A 708
VAL A 501
VAL A 505
 None
 1.32A 4htfA-4yzfA:
undetectable		 4htfA-4yzfA:
14.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M93_B_ACTB305_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN)		 4yzf FAB FRAGMENT OF
IMMUNOGLOBULIN (IGG)
MOLECULE
(Mus
musculus) 		4 / 4 SER E  19
THR E  21
PHE E  81
LYS E  83
 None
 0.81A 4m93B-4yzfE:
24.7		 4m93B-4yzfE:
70.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		5 / 12 ALA A 767
VAL A 461
ILE A 412
ILE A 761
PRO A 458
 None
 0.94A 4njuC-4yzfA:
undetectable		 4njuC-4yzfA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4yzf FAB FRAGMENT OF
IMMUNOGLOBULIN (IGG)
MOLECULE
(Mus
musculus) 		4 / 7 PHE E  24
LEU E   4
THR E  30
VAL E  36
 None
 1.02A 4wnvD-4yzfE:
undetectable		 4wnvD-4yzfE:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 6 VAL A 513
LEU A 382
ARG A 388
ILE A 386
 None
 1.03A 5jw1A-4yzfA:
undetectable		 5jw1A-4yzfA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		6 / 12 HIS A 734
PHE A 411
VAL A 409
ALA A 416
ILE A 421
ALA A 420
 None
 1.40A 5n0tB-4yzfA:
undetectable		 5n0tB-4yzfA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 530
PHE A 526
SER A 799
ILE A 684
 None
 0.93A 5n5dA-4yzfA:
undetectable		 5n5dA-4yzfA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		5 / 11 TYR A 794
VAL A 797
SER A 525
ASN A 736
VAL A 732
 None
 1.33A 6hu9A-4yzfA:
undetectable
6hu9E-4yzfA:
undetectable
6hu9I-4yzfA:
undetectable		 6hu9A-4yzfA:
19.54
6hu9E-4yzfA:
10.75
6hu9I-4yzfA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens) 		5 / 10 TYR A 794
VAL A 797
SER A 525
ASN A 736
VAL A 732
 None
 1.27A 6hu9L-4yzfA:
undetectable
6hu9P-4yzfA:
undetectable
6hu9T-4yzfA:
undetectable		 6hu9L-4yzfA:
19.54
6hu9P-4yzfA:
10.75
6hu9T-4yzfA:
5.65