SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yzg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 10 ASP A 238
GLY A 160
GLY A 179
ILE A 178
ILE A 230
 None
 0.96A 1muiA-4yzgA:
undetectable		 1muiA-4yzgA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 12 ILE A 178
ASP A  93
GLY A 160
GLY A  94
LEU A 145
 None
MN  A 402 ( 2.6A)
None
MN  A 401 (-4.2A)
None
 1.08A 1rjdA-4yzgA:
undetectable		 1rjdA-4yzgA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 12 ILE A 178
ASP A  93
GLY A 160
GLY A  94
LEU A 145
 None
MN  A 402 ( 2.6A)
None
MN  A 401 (-4.2A)
None
 1.08A 1rjdB-4yzgA:
undetectable		 1rjdB-4yzgA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		4 / 8 LEU A 149
TRP A 148
GLY A 153
ASP A 154
 None
 1.00A 1rmtC-4yzgA:
undetectable		 1rmtC-4yzgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 10 ASP A 238
GLY A 160
GLY A 179
ILE A 178
ILE A 230
 None
 0.90A 2aquA-4yzgA:
undetectable		 2aquA-4yzgA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 12 ASP A 238
GLY A 160
GLY A 179
ILE A 178
ILE A 230
 None
 0.97A 2o4sB-4yzgA:
undetectable		 2o4sB-4yzgA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 10 ASP A 238
GLY A 160
GLY A 179
ILE A 178
ILE A 230
 None
 0.93A 2r5qD-4yzgA:
undetectable		 2r5qD-4yzgA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 12 ASP A 238
GLY A 160
GLY A 179
ILE A 178
ILE A 230
 None
 0.90A 2z54B-4yzgA:
undetectable		 2z54B-4yzgA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 12 PHE A 236
VAL A 141
PHE A  86
ALA A 176
TYR A  88
 None
 1.34A 3apvB-4yzgA:
undetectable		 3apvB-4yzgA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 10 ASP A 238
GLY A 160
GLY A 179
ILE A 178
ILE A 230
 None
 0.96A 3ekyA-4yzgA:
undetectable		 3ekyA-4yzgA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 11 ASP A  74
LEU A 333
SER A 337
PHE A  68
ASP A 296
 MN  A 402 ( 4.8A)
None
None
None
MN  A 402 (-2.6A)
 1.45A 3ko0C-4yzgA:
undetectable
3ko0D-4yzgA:
undetectable
3ko0E-4yzgA:
undetectable
3ko0F-4yzgA:
undetectable		 3ko0C-4yzgA:
18.77
3ko0D-4yzgA:
18.77
3ko0E-4yzgA:
18.77
3ko0F-4yzgA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 11 ASP A 296
LEU A 333
SER A 337
PHE A  68
ASP A  74
 MN  A 402 (-2.6A)
None
None
None
MN  A 402 ( 4.8A)
 1.39A 3ko0C-4yzgA:
undetectable
3ko0D-4yzgA:
undetectable
3ko0E-4yzgA:
undetectable
3ko0F-4yzgA:
undetectable		 3ko0C-4yzgA:
18.77
3ko0D-4yzgA:
18.77
3ko0E-4yzgA:
18.77
3ko0F-4yzgA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 11 ASP A 296
ASP A  74
LEU A 333
SER A 337
PHE A  68
 MN  A 402 (-2.6A)
MN  A 402 ( 4.8A)
None
None
None
 1.38A 3ko0Q-4yzgA:
undetectable
3ko0R-4yzgA:
undetectable
3ko0S-4yzgA:
undetectable
3ko0T-4yzgA:
undetectable		 3ko0Q-4yzgA:
18.77
3ko0R-4yzgA:
18.77
3ko0S-4yzgA:
18.77
3ko0T-4yzgA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 9 ASP A 238
GLY A 160
GLY A 179
ILE A 178
ILE A 230
 None
 0.92A 3nujB-4yzgA:
undetectable		 3nujB-4yzgA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 9 ASP A 238
GLY A 160
GLY A 179
ILE A 178
ILE A 230
 None
 0.93A 3nuoB-4yzgA:
undetectable		 3nuoB-4yzgA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 10 ASP A 238
GLY A 160
GLY A 179
ILE A 178
ILE A 230
 None
 0.94A 3s43B-4yzgA:
undetectable		 3s43B-4yzgA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 10 ASP A 238
GLY A 160
GLY A 179
ILE A 178
ILE A 230
 None
 0.96A 3ttpA-4yzgA:
undetectable		 3ttpA-4yzgA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 12 ASP A 238
GLY A 160
GLY A 179
ILE A 178
ILE A 230
 None
 0.98A 4njvA-4yzgA:
undetectable		 4njvA-4yzgA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 11 ASP A 238
GLY A 160
GLY A 179
ILE A 178
ILE A 230
 None
 0.92A 4njvB-4yzgA:
undetectable		 4njvB-4yzgA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 11 ASP A 238
GLY A 160
GLY A 179
ILE A 178
ILE A 230
 None
 0.99A 4njvC-4yzgA:
undetectable		 4njvC-4yzgA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		4 / 6 ARG A  69
ASP A 296
GLY A 297
ASP A 300
 SO4  A 403 (-2.6A)
MN  A 402 (-2.6A)
None
None
 1.23A 5hp1A-4yzgA:
undetectable		 5hp1A-4yzgA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 12 ARG A 169
ILE A 291
ALA A 183
THR A 195
ALA A 176
 None
 1.10A 5veuA-4yzgA:
undetectable		 5veuA-4yzgA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 12 VAL A 232
PHE A 138
SER A 161
PHE A 236
HIS A 177
 None
 1.03A 6ap6A-4yzgA:
undetectable		 6ap6A-4yzgA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 12 VAL A 232
PHE A 138
SER A 161
PHE A 236
HIS A 177
 None
 1.02A 6ap6B-4yzgA:
undetectable		 6ap6B-4yzgA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 12 ASP A 238
GLY A 160
GLY A 179
ILE A 178
ILE A 230
 None
 0.90A 6difB-4yzgA:
undetectable		 6difB-4yzgA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		4 / 7 ASP A 157
GLY A  94
SER A 159
GLY A 160
 None
MN  A 401 (-4.2A)
None
None
 0.69A 6ekzA-4yzgA:
undetectable		 6ekzA-4yzgA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 12 VAL A  91
ASP A  75
ALA A 294
SER A 181
LEU A 328
 None
 1.14A 6ew0F-4yzgA:
undetectable		 6ew0F-4yzgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4yzg PROTEIN PHOSPHATASE
2C 57
(Arabidopsis
thaliana) 		5 / 12 VAL A  91
ASP A  75
ALA A 294
SER A 181
LEU A 328
 None
 1.14A 6ew0G-4yzgA:
undetectable		 6ew0G-4yzgA:
16.27