SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		5 / 12 HIS A 288
GLY A 287
GLY A 272
PHE A 269
ALA A 206
 None
OLA  A 406 (-3.5A)
None
RET  A 401 ( 4.4A)
None
 1.07A 3sudA-4yziA:
undetectable		 3sudA-4yziA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		5 / 12 HIS A 288
GLY A 287
GLY A 272
PHE A 269
ALA A 206
 None
OLA  A 406 (-3.5A)
None
RET  A 401 ( 4.4A)
None
 1.02A 3sudD-4yziA:
undetectable		 3sudD-4yziA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		5 / 12 HIS A 288
GLY A 287
GLY A 272
PHE A 269
ALA A 206
 None
OLA  A 406 (-3.5A)
None
RET  A 401 ( 4.4A)
None
 1.11A 3sueB-4yziA:
undetectable		 3sueB-4yziA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		4 / 6 THR A 285
GLY A 287
ILE A 291
LEU A  94
 None
OLA  A 406 (-3.5A)
None
None
 0.72A 4ac9C-4yziA:
undetectable		 4ac9C-4yziA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		4 / 6 THR A 285
GLY A 287
ILE A 291
LEU A  94
 None
OLA  A 406 (-3.5A)
None
None
 0.77A 4acaC-4yziA:
undetectable		 4acaC-4yziA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		4 / 6 THR A 285
GLY A 287
ILE A 291
LEU A  94
 None
OLA  A 406 (-3.5A)
None
None
 0.83A 4acbC-4yziA:
undetectable		 4acbC-4yziA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		4 / 8 ASP A  40
ASP A 142
TYR A 148
GLU A 143
 ZN  A 407 (-2.8A)
ZN  A 407 ( 2.3A)
None
None
 0.99A 4xjeA-4yziA:
undetectable		 4xjeA-4yziA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		4 / 8 ASP A  40
ASP A 142
TYR A 148
GLU A 143
 ZN  A 407 (-2.8A)
ZN  A 407 ( 2.3A)
None
None
 1.02A 5cfsA-4yziA:
undetectable		 5cfsA-4yziA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		4 / 6 CYH A 298
LEU A 293
CYH A 105
LEU A 101
 None
 1.00A 5hpuC-4yziA:
undetectable
5hpuD-4yziA:
undetectable		 5hpuC-4yziA:
10.48
5hpuD-4yziA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		4 / 6 CYH A 298
LEU A 293
CYH A 105
LEU A 101
 None
 1.17A 5hpuC-4yziA:
undetectable
5hpuD-4yziA:
undetectable		 5hpuC-4yziA:
10.48
5hpuD-4yziA:
9.05