SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4yzk TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Streptomyces
blastmyceticus) 		4 / 7 TYR A 348
GLU A 106
VAL A 334
MET A 343
 None
 1.18A 1tv8A-4yzkA:
undetectable		 1tv8A-4yzkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4yzk TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Streptomyces
blastmyceticus) 		4 / 8 TYR A 348
GLU A 106
VAL A 334
MET A 343
 None
 1.19A 2fb2A-4yzkA:
undetectable		 2fb2A-4yzkA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4yzk TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Streptomyces
blastmyceticus) 		4 / 5 ARG A 142
ALA A 138
ASP A 135
TRP A  83
 None
 1.49A 2xrzA-4yzkA:
undetectable		 2xrzA-4yzkA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4yzk TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Streptomyces
blastmyceticus) 		5 / 12 ILE A 172
LEU A 190
MET A 239
HIS A 174
LEU A 143
 None
 1.26A 3cs8A-4yzkA:
undetectable		 3cs8A-4yzkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4yzk TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Streptomyces
blastmyceticus) 		5 / 12 ILE A 369
VAL A 323
GLY A 325
LEU A 352
ARG A 331
 None
 1.01A 3em0B-4yzkA:
2.3		 3em0B-4yzkA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 4yzk TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Streptomyces
blastmyceticus) 		3 / 3 PHE A  36
TYR A  47
TYR A 388
 None
 1.09A 4ffwA-4yzkA:
undetectable		 4ffwA-4yzkA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4yzk TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Streptomyces
blastmyceticus) 		5 / 11 HIS A 324
ASN A 367
TYR A 348
ASN A 286
LEU A 282
 None
 1.35A 4m83A-4yzkA:
undetectable		 4m83A-4yzkA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4yzk TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Streptomyces
blastmyceticus) 		4 / 7 ILE A 369
PHE A 379
ARG A 331
LEU A 383
 None
 0.94A 5iy5N-4yzkA:
undetectable
5iy5W-4yzkA:
undetectable		 5iy5N-4yzkA:
21.92
5iy5W-4yzkA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4yzk TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Streptomyces
blastmyceticus) 		5 / 10 LEU A 282
HIS A 273
ALA A 270
PHE A 303
LEU A 224
 None
 1.37A 5mm4B-4yzkA:
undetectable		 5mm4B-4yzkA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 4yzk TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Streptomyces
blastmyceticus) 		5 / 9 HIS A 364
ASP A 327
LYS A  54
ALA A 354
ASP A 353
 None
 1.43A 6c2mA-4yzkA:
undetectable		 6c2mA-4yzkA:
13.29