SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yzo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 4 ARG A 150
ALA A 139
ALA A 273
GLU A 195
 None
 0.90A 1e7bB-4yzoA:
undetectable		 1e7bB-4yzoA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 6 ASN A 231
ALA A 247
GLY A 361
TYR A 232
 None
 1.06A 1gfzA-4yzoA:
undetectable		 1gfzA-4yzoA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 269
GLY A 359
GLY A 361
ASN A 362
ASN A  74
 None
 1.16A 1likA-4yzoA:
undetectable		 1likA-4yzoA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 11 ALA A 255
ILE A 284
GLY A 285
VAL A 351
ILE A 368
 None
 0.97A 1sduA-4yzoA:
undetectable		 1sduA-4yzoA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  83
GLY A  80
GLY A  77
SER A  76
ALA A 364
 None
 0.94A 1vq1B-4yzoA:
undetectable		 1vq1B-4yzoA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 6 LEU A 131
GLY A 359
SER A  76
HIS A 320
 None
 0.78A 1yajF-4yzoA:
undetectable		 1yajF-4yzoA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A 322
ASN A  74
SER A  81
GLY A 359
LEU A 131
 None
 1.13A 2zw9A-4yzoA:
undetectable		 2zw9A-4yzoA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A 255
ILE A 284
GLY A 285
VAL A 351
ILE A 368
 None
 0.88A 3cyxB-4yzoA:
undetectable		 3cyxB-4yzoA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 10 ALA A 330
GLY A 352
ILE A 368
ALA A   3
ILE A   4
 None
 1.02A 3ekwA-4yzoA:
undetectable		 3ekwA-4yzoA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A 330
ILE A   9
SER A 335
GLY A 323
ILE A  83
 None
PEG  A 402 ( 4.0A)
PEG  A 402 (-3.1A)
None
None
 1.44A 3lbdA-4yzoA:
undetectable		 3lbdA-4yzoA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 9 GLY A 102
ALA A 324
ILE A 322
GLY A  80
ILE A  83
 None
 1.00A 3ogpA-4yzoA:
undetectable		 3ogpA-4yzoA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 9 GLY A 102
ALA A 324
ILE A 322
GLY A  80
ILE A  83
 None
 1.02A 3ogpB-4yzoA:
undetectable		 3ogpB-4yzoA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A 102
ALA A 324
ILE A 322
GLY A  80
ILE A  83
 None
 0.92A 3ogqB-4yzoA:
undetectable		 3ogqB-4yzoA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 4 ASN A 160
VAL A 296
THR A 274
ILE A 153
 None
 1.45A 4retA-4yzoA:
undetectable		 4retA-4yzoA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 4 ASN A 160
VAL A 296
THR A 274
ILE A 275
 None
 1.38A 4retA-4yzoA:
undetectable		 4retA-4yzoA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 4 ASN A 160
VAL A 296
THR A 274
ILE A 153
 None
 1.45A 4retC-4yzoA:
undetectable		 4retC-4yzoA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 4 ASN A 160
VAL A 296
THR A 274
ILE A 275
 None
 1.38A 4retC-4yzoA:
undetectable		 4retC-4yzoA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 7 VAL A 206
ILE A 224
ARG A 350
ILE A 368
 None
 0.88A 4uxqA-4yzoA:
undetectable		 4uxqA-4yzoA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A  77
SER A  41
SER A 229
ALA A 358
ASN A 362
 None
 1.29A 4ymgB-4yzoA:
undetectable		 4ymgB-4yzoA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 5 SER A  76
ALA A 358
HIS A 320
LEU A 131
 None
 1.32A 5dzkb-4yzoA:
undetectable
5dzkp-4yzoA:
undetectable		 5dzkb-4yzoA:
19.79
5dzkp-4yzoA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 5 SER A  76
ALA A 358
HIS A 320
LEU A 131
 None
 1.32A 5dzkc-4yzoA:
undetectable
5dzkq-4yzoA:
undetectable		 5dzkc-4yzoA:
19.79
5dzkq-4yzoA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 5 SER A  76
ALA A 358
HIS A 320
LEU A 131
 None
 1.38A 5dzkf-4yzoA:
undetectable
5dzkt-4yzoA:
undetectable		 5dzkf-4yzoA:
19.79
5dzkt-4yzoA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 6 SER A  76
ALA A 358
HIS A 320
LEU A 131
 None
 1.28A 5dzkg-4yzoA:
undetectable
5dzku-4yzoA:
undetectable		 5dzkg-4yzoA:
19.79
5dzku-4yzoA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 7 VAL A  38
LEU A  31
VAL A  23
THR A  27
 None
 1.01A 5e4dA-4yzoA:
undetectable
5e4dB-4yzoA:
undetectable		 5e4dA-4yzoA:
18.44
5e4dB-4yzoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 7 VAL A  40
LEU A  62
VAL A  26
THR A  27
 None
 1.02A 5e4dA-4yzoA:
undetectable
5e4dB-4yzoA:
undetectable		 5e4dA-4yzoA:
18.44
5e4dB-4yzoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 SER A 356
GLY A  77
GLY A 102
GLY A  80
VAL A  23
 None
 0.87A 5ec8A-4yzoA:
undetectable		 5ec8A-4yzoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  83
ILE A 227
ALA A 255
ILE A 264
ALA A 267
 None
 1.08A 5vceA-4yzoA:
0.2		 5vceA-4yzoA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 PRO A 311
GLY A 313
ILE A 307
GLY A 292
ASP A 271
 None
 1.21A 5wwsB-4yzoA:
undetectable		 5wwsB-4yzoA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 10 VAL A 327
GLY A  79
ALA A 204
SER A  41
ASN A  42
 None
 1.19A 5x6yB-4yzoA:
undetectable		 5x6yB-4yzoA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 6 VAL A 296
TYR A 142
ILE A 278
GLU A 282
 None
 0.97A 5z3jA-4yzoA:
undetectable		 5z3jA-4yzoA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 8 LEU A  62
TYR A  61
THR A  27
ASN A  18
 None
 0.79A 6c71B-4yzoA:
undetectable		 6c71B-4yzoA:
12.02