SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		5 / 11 ILE A 315
ALA A 292
ILE A  62
ILE A 307
ILE A  47
 ILE  A 315 ( 0.7A)
ALA  A 292 ( 0.0A)
ILE  A  62 ( 0.6A)
ILE  A 307 ( 0.6A)
ILE  A  47 ( 0.7A)
 1.08A 1dyrA-4yzrA:
undetectable		 1dyrA-4yzrA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 8 LEU A 237
VAL A 240
THR A 245
VAL A 288
 LEU  A 237 ( 0.6A)
VAL  A 240 ( 0.5A)
THR  A 245 ( 0.8A)
VAL  A 288 ( 0.6A)
 0.52A 1dz9A-4yzrA:
42.6		 1dz9A-4yzrA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 6 HIS A  99
ASP A  95
ASP A  65
PRO A  97
 HIS  A  99 (-1.0A)
ASP  A  95 ( 0.6A)
ASP  A  65 ( 0.6A)
PRO  A  97 ( 1.0A)
 1.49A 1ilqA-4yzrA:
undetectable
1ilqC-4yzrA:
undetectable		 1ilqA-4yzrA:
13.02
1ilqC-4yzrA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 8 LEU A 237
VAL A 240
THR A 245
VAL A 288
 LEU  A 237 ( 0.6A)
VAL  A 240 ( 0.5A)
THR  A 245 ( 0.8A)
VAL  A 288 ( 0.6A)
 0.60A 1o76B-4yzrA:
42.4		 1o76B-4yzrA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 8 LEU A 237
VAL A 240
THR A 245
VAL A 288
 LEU  A 237 ( 0.6A)
VAL  A 240 ( 0.5A)
THR  A 245 ( 0.8A)
VAL  A 288 ( 0.6A)
 0.70A 1uyuA-4yzrA:
42.7		 1uyuA-4yzrA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 5 LEU A 157
PRO A 150
VAL A 153
ILE A 154
 LEU  A 157 ( 0.6A)
PRO  A 150 ( 1.1A)
VAL  A 153 ( 0.6A)
ILE  A 154 ( 0.7A)
 1.00A 2aoiB-4yzrA:
undetectable		 2aoiB-4yzrA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		5 / 12 HIS A 342
ASN A 340
ALA A 358
ALA A 277
ILE A 274
 HIS  A 342 ( 1.0A)
ASN  A 340 ( 0.6A)
ALA  A 358 (-0.0A)
ALA  A 277 ( 0.0A)
ILE  A 274 ( 0.4A)
 1.08A 2h42B-4yzrA:
undetectable		 2h42B-4yzrA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 6 ILE A  62
ARG A  64
SER A 319
MET A 290
 ILE  A  62 ( 0.6A)
ARG  A  64 (-0.6A)
SER  A 319 ( 0.0A)
MET  A 290 ( 0.0A)
 1.12A 2qd3B-4yzrA:
undetectable		 2qd3B-4yzrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		5 / 10 PHE A 345
SER A 344
SER A 286
GLY A 362
ALA A 358
 PHE  A 345 (-1.3A)
SER  A 344 (-0.0A)
SER  A 286 ( 0.0A)
GLY  A 362 ( 0.0A)
ALA  A 358 (-0.0A)
 1.31A 2x2iB-4yzrA:
undetectable		 2x2iB-4yzrA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 7 LEU A 237
VAL A 240
THR A 245
VAL A 288
 LEU  A 237 ( 0.6A)
VAL  A 240 ( 0.5A)
THR  A 245 ( 0.8A)
VAL  A 288 ( 0.6A)
 0.85A 2zaxA-4yzrA:
42.5		 2zaxA-4yzrA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 7 LEU A 237
VAL A 240
THR A 245
VAL A 288
 LEU  A 237 ( 0.6A)
VAL  A 240 ( 0.5A)
THR  A 245 ( 0.8A)
VAL  A 288 ( 0.6A)
 0.80A 3fwgB-4yzrA:
42.5		 3fwgB-4yzrA:
28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 7 LEU A 237
VAL A 240
THR A 245
VAL A 288
 LEU  A 237 ( 0.6A)
VAL  A 240 ( 0.5A)
THR  A 245 ( 0.8A)
VAL  A 288 ( 0.6A)
 0.89A 3fwiA-4yzrA:
42.1		 3fwiA-4yzrA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 7 MET A 234
LEU A 216
ARG A 103
GLY A 354
 MET  A 234 ( 0.0A)
LEU  A 216 ( 0.6A)
ARG  A 103 (-0.6A)
GLY  A 354 (-0.0A)
 1.02A 3hcnA-4yzrA:
undetectable		 3hcnA-4yzrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		5 / 12 ALA A 146
ILE A 376
LEU A 258
ALA A 365
VAL A 278
 ALA  A 146 ( 0.0A)
ILE  A 376 ( 0.7A)
LEU  A 258 ( 0.6A)
ALA  A 365 ( 0.0A)
VAL  A 278 ( 0.6A)
 1.03A 3rukA-4yzrA:
31.4		 3rukA-4yzrA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 8 GLY A 318
ASN A 321
ARG A 337
PRO A  17
 GLY  A 318 ( 0.0A)
ASN  A 321 ( 0.6A)
ARG  A 337 ( 0.6A)
PRO  A  17 ( 1.0A)
 0.94A 4j4vC-4yzrA:
2.5		 4j4vC-4yzrA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		3 / 3 ARG A  61
ASP A  59
TYR A 302
 ARG  A  61 ( 0.6A)
ASP  A  59 ( 0.6A)
TYR  A 302 ( 1.3A)
 0.83A 4yo9B-4yzrA:
undetectable		 4yo9B-4yzrA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 8 PHE A 168
ILE A 160
PHE A 193
LEU A 216
 PHE  A 168 ( 1.3A)
ILE  A 160 ( 0.6A)
PHE  A 193 ( 1.3A)
LEU  A 216 ( 0.6A)
 0.85A 5hs1A-4yzrA:
29.2		 5hs1A-4yzrA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 8 LEU A 237
VAL A 240
THR A 245
VAL A 288
 LEU  A 237 ( 0.6A)
VAL  A 240 ( 0.5A)
THR  A 245 ( 0.8A)
VAL  A 288 ( 0.6A)
 0.87A 6cp4A-4yzrA:
42.4		 6cp4A-4yzrA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		5 / 10 LEU A 149
LEU A 130
ASP A 131
ILE A 122
GLY A 120
 LEU  A 149 ( 0.5A)
LEU  A 130 ( 0.6A)
ASP  A 131 ( 0.6A)
ILE  A 122 ( 0.7A)
GLY  A 120 ( 0.0A)
 0.94A 6dm0B-4yzrA:
undetectable
6dm0C-4yzrA:
undetectable		 6dm0B-4yzrA:
14.24
6dm0C-4yzrA:
14.24