SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yzt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 ALA A  40
VAL A  72
TRP A  90
 None
 0.71A 1jnoA-4yztA:
undetectable		 1jnoA-4yztA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 ALA A  40
VAL A  72
TRP A  90
 None
 0.71A 1jnoB-4yztA:
undetectable		 1jnoB-4yztA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 ALA A  40
VAL A  72
TRP A  90
 None
 0.84A 1jo3A-4yztA:
undetectable		 1jo3A-4yztA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 ALA A  40
VAL A  72
TRP A  90
 None
 0.84A 1jo3B-4yztA:
undetectable		 1jo3B-4yztA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 ALA A  40
VAL A  72
TRP A  90
 None
 0.86A 1jo4A-4yztA:
undetectable		 1jo4A-4yztA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 ALA A  40
VAL A  72
TRP A  90
 None
 0.86A 1jo4B-4yztA:
undetectable		 1jo4B-4yztA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 ALA A  40
VAL A  72
TRP A  90
 None
 0.75A 1magA-4yztA:
undetectable		 1magA-4yztA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 ALA A  40
VAL A  72
TRP A  90
 None
 0.75A 1magB-4yztA:
undetectable		 1magB-4yztA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 ALA A  40
VAL A  72
TRP A  90
 None
 0.72A 1ng8A-4yztA:
undetectable		 1ng8A-4yztA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 ALA A  40
VAL A  72
TRP A  90
 None
 0.72A 1ng8B-4yztA:
undetectable		 1ng8B-4yztA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 ALA A  40
VAL A  72
TRP A  90
 None
 0.95A 1nrmA-4yztA:
undetectable		 1nrmA-4yztA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 ALA A  40
VAL A  72
TRP A  90
 None
 0.95A 1nrmB-4yztA:
undetectable		 1nrmB-4yztA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 ALA A  40
VAL A  72
TRP A  90
 None
 0.81A 1nruA-4yztA:
undetectable		 1nruA-4yztA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 ALA A  40
VAL A  72
TRP A  90
 None
 0.81A 1nruB-4yztA:
undetectable		 1nruB-4yztA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		5 / 12 ILE A 325
GLY A  31
PHE A  65
VAL A 288
ALA A 291
 None
 1.00A 1tlsA-4yztA:
undetectable		 1tlsA-4yztA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 TRP A 100
LEU A 102
LYS A 148
 None
 1.18A 1yajK-4yztA:
2.2		 1yajK-4yztA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		4 / 5 ALA A 419
ASN A 333
ILE A 335
ASP A 285
 None
 1.16A 1yc2D-4yztA:
undetectable		 1yc2D-4yztA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		5 / 10 MET A 175
LEU A 134
ILE A 112
PRO A 210
GLY A 194
 None
 1.32A 2qd4B-4yztA:
2.3		 2qd4B-4yztA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		6 / 12 ASN A 158
GLU A 159
HIS A 220
TYR A 222
GLU A 268
TRP A 301
 BGC  A 803 (-2.9A)
BGC  A 803 (-2.4A)
BGC  A 803 (-4.3A)
BGC  A 803 ( 4.9A)
BGC  A 803 (-2.8A)
BGC  A 803 (-3.6A)
 0.75A 2v3dA-4yztA:
17.3		 2v3dA-4yztA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		5 / 11 ASN A 158
GLU A 159
TYR A 222
GLU A 268
TRP A 301
 BGC  A 803 (-2.9A)
BGC  A 803 (-2.4A)
BGC  A 803 ( 4.9A)
BGC  A 803 (-2.8A)
BGC  A 803 (-3.6A)
 0.86A 2v3dB-4yztA:
17.4		 2v3dB-4yztA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		5 / 12 VAL A 504
SER A 512
ILE A 531
VAL A 529
VAL A 527
 None
 1.26A 3iw1A-4yztA:
undetectable		 3iw1A-4yztA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		3 / 3 TYR A 269
MET A 299
ILE A  70
 None
 0.82A 4c8bB-4yztA:
undetectable		 4c8bB-4yztA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		4 / 5 GLU A  44
SER A  46
ARG A  93
PRO A  51
 None
EDO  A 802 ( 4.7A)
None
None
 1.11A 4k17B-4yztA:
2.8		 4k17B-4yztA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		4 / 7 VAL A 297
ALA A 291
PHE A 287
TYR A 222
 None
None
None
BGC  A 803 ( 4.9A)
 1.03A 4lb2A-4yztA:
undetectable		 4lb2A-4yztA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		4 / 4 ASN A 361
GLY A 418
ASP A 340
ASP A 285
 None
 1.39A 4n49A-4yztA:
undetectable		 4n49A-4yztA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		4 / 8 HIS A  55
ASP A  58
ARG A 104
TRP A 315
 None
 1.20A 4uhxA-4yztA:
undetectable		 4uhxA-4yztA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		4 / 8 HIS A  55
ASP A  58
ARG A 104
TRP A 315
 None
 1.20A 4uhxA-4yztA:
undetectable		 4uhxA-4yztA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4yzt CELLULOSE HYDROLASE
(Bacillus
licheniformis) 		5 / 12 VAL A  68
ASP A  59
ALA A 101
ARG A  69
LEU A  38
 None
 1.41A 5syfB-4yztA:
undetectable		 5syfB-4yztA:
20.60