SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 10 ARG A 646
VAL A 568
TYR A 230
PRO A 651
GLY A 644
 None
 1.36A 13gsA-4yzwA:
undetectable		 13gsA-4yzwA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 9 ARG A 646
VAL A 568
TYR A 230
PRO A 651
GLY A 644
 None
 1.36A 13gsB-4yzwA:
undetectable		 13gsB-4yzwA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 8 GLY A 479
HIS A 163
ALA A 488
ILE A 480
 None
 0.71A 1gtnE-4yzwA:
undetectable
1gtnF-4yzwA:
undetectable		 1gtnE-4yzwA:
7.22
1gtnF-4yzwA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_B_MTXB2278_1
(PTERIDINE REDUCTASE
2)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 11 ARG A 244
SER A 233
ASP A 377
PHE A  99
LEU A 363
 None
 1.18A 1mxfB-4yzwA:
undetectable		 1mxfB-4yzwA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 11 ARG A 244
SER A 233
ASP A 377
PHE A  99
LEU A 363
 None
 1.20A 1mxfC-4yzwA:
undetectable		 1mxfC-4yzwA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 11 ARG A 244
SER A 233
ASP A 377
PHE A  99
LEU A 363
 None
 1.18A 1mxfD-4yzwA:
undetectable		 1mxfD-4yzwA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 419
HIS A 379
HIS A 252
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
 0.68A 1rjoA-4yzwA:
undetectable		 1rjoA-4yzwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 4 ASP A 423
LEU A 541
LEU A 540
LEU A 256
 None
 1.40A 1u18A-4yzwA:
undetectable		 1u18A-4yzwA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 12 SER A 400
HIS A 419
HIS A 252
VAL A 406
PHE A  99
 None
CU  A 802 (-3.1A)
CU  A 801 (-3.2A)
None
None
 1.48A 1uobA-4yzwA:
undetectable		 1uobA-4yzwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 419
HIS A 379
HIS A 252
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
 0.69A 1w2zA-4yzwA:
undetectable		 1w2zA-4yzwA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 419
HIS A 379
HIS A 252
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
 0.70A 1w2zB-4yzwA:
undetectable		 1w2zB-4yzwA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 419
HIS A 379
HIS A 252
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
 0.70A 1w2zC-4yzwA:
undetectable		 1w2zC-4yzwA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 7 PHE A 674
PHE A 615
MET A 617
VAL A 518
 None
 1.08A 1wrlA-4yzwA:
undetectable
1wrlB-4yzwA:
undetectable		 1wrlA-4yzwA:
7.64
1wrlB-4yzwA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 7 SER A  95
SER A  97
PHE A 388
ARG A 312
 None
 1.31A 2c8aA-4yzwA:
undetectable		 2c8aA-4yzwA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 6 SER A  95
SER A  97
PHE A 388
ARG A 312
 None
 1.36A 2c8aC-4yzwA:
undetectable		 2c8aC-4yzwA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 6 TRP A 596
LEU A 602
LEU A 545
VAL A 568
 None
 1.13A 2dqyC-4yzwA:
undetectable		 2dqyC-4yzwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 419
HIS A 379
HIS A 252
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
 0.70A 2oqeA-4yzwA:
undetectable		 2oqeA-4yzwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 419
HIS A 379
HIS A 252
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
 0.70A 2oqeB-4yzwA:
undetectable		 2oqeB-4yzwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 419
HIS A 379
HIS A 252
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
 0.70A 2oqeC-4yzwA:
undetectable		 2oqeC-4yzwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 419
HIS A 379
HIS A 252
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
 0.71A 2oqeD-4yzwA:
undetectable		 2oqeD-4yzwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 419
HIS A 379
HIS A 252
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
 0.69A 2oqeF-4yzwA:
undetectable		 2oqeF-4yzwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 11 LEU A 545
ILE A 520
PHE A 500
ALA A 684
LEU A 504
 None
 1.17A 2q72A-4yzwA:
undetectable		 2q72A-4yzwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 11 LEU A 545
ILE A 520
PHE A 500
ALA A 684
LEU A 504
 None
 1.18A 2qjuA-4yzwA:
1.8		 2qjuA-4yzwA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 223
MET A 251
MET A 410
 CU  A 801 (-3.0A)
None
None
 1.07A 2vj1A-4yzwA:
undetectable		 2vj1A-4yzwA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 419
HIS A 379
HIS A 252
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
 0.69A 2w0qA-4yzwA:
undetectable		 2w0qA-4yzwA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 419
HIS A 379
HIS A 252
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
 0.69A 2w0qB-4yzwA:
undetectable		 2w0qB-4yzwA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 6 PRO A 651
SER A 652
GLU A 246
TYR A 650
 None
 1.30A 2x7hA-4yzwA:
undetectable		 2x7hA-4yzwA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 11 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 384
PRO A 101
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.88A 2zweA-4yzwA:
6.2
2zweB-4yzwA:
undetectable		 2zweA-4yzwA:
17.54
2zweB-4yzwA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 11 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 384
PRO A 101
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.86A 2zwfA-4yzwA:
9.2
2zwfB-4yzwA:
undetectable		 2zwfA-4yzwA:
17.54
2zwfB-4yzwA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 11 HIS A 227
HIS A 223
HIS A 383
HIS A 379
ASP A 423
 CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
None
 1.40A 2zwfA-4yzwA:
9.2
2zwfB-4yzwA:
undetectable		 2zwfA-4yzwA:
17.54
2zwfB-4yzwA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 11 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 384
PRO A 101
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.90A 2zwgA-4yzwA:
9.0
2zwgB-4yzwA:
undetectable		 2zwgA-4yzwA:
17.54
2zwgB-4yzwA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 ILE A 170
MET A 178
ILE A 480
HIS A 163
 None
 1.15A 3eteB-4yzwA:
undetectable
3eteC-4yzwA:
undetectable		 3eteB-4yzwA:
22.73
3eteC-4yzwA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 419
HIS A 379
HIS A 252
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
 0.71A 3hiiA-4yzwA:
undetectable		 3hiiA-4yzwA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 419
HIS A 379
HIS A 252
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
 0.72A 3hiiB-4yzwA:
undetectable		 3hiiB-4yzwA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 ASP A 167
PHE A 165
SER A  95
 None
 1.01A 3i5uB-4yzwA:
undetectable		 3i5uB-4yzwA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_2
(GENOME POLYPROTEIN)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 4 GLN A 168
PHE A 165
TYR A 141
VAL A 474
 None
 1.26A 3keeA-4yzwA:
0.0		 3keeA-4yzwA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 223
SER A  97
ASN A 380
 CU  A 801 (-3.0A)
None
None
 0.91A 3s8pB-4yzwA:
0.0		 3s8pB-4yzwA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 227
SER A  97
ASN A 380
 CU  A 801 (-3.2A)
None
None
 0.85A 3s8pB-4yzwA:
0.0		 3s8pB-4yzwA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 4 PHE A 642
TYR A 249
ARG A 104
LEU A 228
 None
 1.50A 3sueA-4yzwA:
undetectable		 3sueA-4yzwA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 TYR A 259
LEU A 247
ARG A 258
 None
 0.81A 3sufB-4yzwA:
undetectable		 3sufB-4yzwA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 12 LEU A 504
ILE A 520
TYR A 502
GLN A 562
SER A 566
 None
 1.27A 4a83A-4yzwA:
undetectable		 4a83A-4yzwA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 10 GLY A 376
ILE A 362
ILE A 335
LEU A 332
ILE A 425
 None
 1.10A 4dt8B-4yzwA:
undetectable		 4dt8B-4yzwA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 PHE A 492
ILE A 217
GLY A 218
THR A 575
 None
 0.89A 4ejjC-4yzwA:
undetectable		 4ejjC-4yzwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 8 MET A 403
ARG A 263
ARG A 417
VAL A 281
 None
 1.07A 4f4dB-4yzwA:
undetectable		 4f4dB-4yzwA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 LEU A 455
ARG A 457
ILE A 695
ASN A 692
 None
 1.26A 4i00A-4yzwA:
undetectable		 4i00A-4yzwA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 LEU A 115
LYS A 112
THR A 111
 None
 0.59A 4lj0A-4yzwA:
undetectable		 4lj0A-4yzwA:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 7 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 406
ALA A 409
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.65A 4p6sA-4yzwA:
8.9		 4p6sA-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 7 HIS A 379
HIS A 383
HIS A 223
HIS A 227
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
 0.86A 4p6sA-4yzwA:
8.9		 4p6sA-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 7 HIS A 383
HIS A 379
HIS A 227
HIS A 223
ALA A 409
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
None
 1.09A 4p6sA-4yzwA:
8.9		 4p6sA-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 7 HIS A 383
HIS A 419
HIS A 223
ALA A 409
 CU  A 802 (-3.2A)
CU  A 802 (-3.1A)
CU  A 801 (-3.0A)
None
 0.87A 4p6sA-4yzwA:
8.9		 4p6sA-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		6 / 7 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 406
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
 0.69A 4p6sB-4yzwA:
8.7		 4p6sB-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 7 HIS A 227
HIS A 223
HIS A 383
HIS A 379
 CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
 0.98A 4p6sB-4yzwA:
8.7		 4p6sB-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 7 HIS A 379
HIS A 383
HIS A 223
HIS A 227
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
 0.79A 4p6sB-4yzwA:
8.7		 4p6sB-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 7 HIS A 383
HIS A 379
HIS A 227
HIS A 223
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.89A 4p6sB-4yzwA:
8.7		 4p6sB-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 8 GLU A 102
ASP A 315
ARG A 312
TRP A 327
 None
 1.07A 4uhxA-4yzwA:
1.6		 4uhxA-4yzwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 7 TYR A 640
ARG A 561
SER A 566
GLU A 544
 None
 1.33A 4xzkA-4yzwA:
undetectable		 4xzkA-4yzwA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 6 SER A 366
ARG A 354
GLY A 355
GLU A 352
 None
 0.78A 5cdqA-4yzwA:
undetectable
5cdqC-4yzwA:
undetectable
5cdqD-4yzwA:
undetectable		 5cdqA-4yzwA:
22.21
5cdqC-4yzwA:
22.21
5cdqD-4yzwA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 223
SER A  97
ASN A 380
 CU  A 801 (-3.0A)
None
None
 0.91A 5cprB-4yzwA:
undetectable		 5cprB-4yzwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 227
SER A  97
ASN A 380
 CU  A 801 (-3.2A)
None
None
 0.84A 5cprB-4yzwA:
undetectable		 5cprB-4yzwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 9 GLY A 595
THR A 569
TRP A 596
GLN A 168
ASN A 220
 None
 1.17A 5fhzB-4yzwA:
undetectable		 5fhzB-4yzwA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 10 GLY A 595
THR A 569
TRP A 596
GLN A 168
ASN A 220
 None
 1.14A 5fhzC-4yzwA:
undetectable		 5fhzC-4yzwA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 7 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 406
ALA A 409
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.64A 5i3aA-4yzwA:
8.8		 5i3aA-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 7 HIS A 379
HIS A 383
HIS A 223
HIS A 227
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
 0.85A 5i3aA-4yzwA:
8.8		 5i3aA-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 7 HIS A 383
HIS A 379
HIS A 227
HIS A 223
ALA A 409
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
None
 1.08A 5i3aA-4yzwA:
8.8		 5i3aA-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 7 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 406
ALA A 409
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.65A 5i3aB-4yzwA:
9.0		 5i3aB-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 7 HIS A 379
HIS A 383
HIS A 223
HIS A 227
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
 0.82A 5i3aB-4yzwA:
9.0		 5i3aB-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 7 HIS A 383
HIS A 379
HIS A 227
HIS A 223
ALA A 409
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
None
 1.09A 5i3aB-4yzwA:
9.0		 5i3aB-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 7 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 406
ALA A 409
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.66A 5i3bA-4yzwA:
9.1		 5i3bA-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 7 HIS A 379
HIS A 383
HIS A 223
HIS A 227
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
 0.89A 5i3bA-4yzwA:
9.1		 5i3bA-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 7 HIS A 383
HIS A 379
HIS A 227
HIS A 223
ALA A 409
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
None
 1.09A 5i3bA-4yzwA:
9.1		 5i3bA-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 5 HIS A 223
HIS A 227
HIS A 383
VAL A 406
ALA A 409
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
None
 0.72A 5i3bB-4yzwA:
9.0		 5i3bB-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 HIS A 383
HIS A 379
HIS A 223
ALA A 409
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 801 (-3.0A)
None
 0.99A 5i3bB-4yzwA:
9.0		 5i3bB-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 HIS A 383
HIS A 419
HIS A 223
ALA A 409
 CU  A 802 (-3.2A)
CU  A 802 (-3.1A)
CU  A 801 (-3.0A)
None
 0.97A 5i3bB-4yzwA:
9.0		 5i3bB-4yzwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 10 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
 0.68A 5m8nA-4yzwA:
7.1		 5m8nA-4yzwA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 10 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
 0.72A 5m8nB-4yzwA:
6.8		 5m8nB-4yzwA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 9 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
 0.68A 5m8nC-4yzwA:
7.1		 5m8nC-4yzwA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 7 HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 406
 CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
 0.61A 5m8rA-4yzwA:
7.2		 5m8rA-4yzwA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 8 HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 406
 CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
 0.62A 5m8rB-4yzwA:
7.1		 5m8rB-4yzwA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		6 / 8 HIS A 227
HIS A 379
ASN A 380
HIS A 383
GLY A 404
VAL A 406
 CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.69A 5m8rC-4yzwA:
7.1		 5m8rC-4yzwA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 8 HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 406
 CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
 0.65A 5m8rD-4yzwA:
7.1		 5m8rD-4yzwA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0
(LACCASE 2)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 5 HIS A 419
HIS A 379
HIS A 223
HIS A 252
HIS A 227
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
 1.37A 5mejA-4yzwA:
undetectable		 5mejA-4yzwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0
(LACCASE 2)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 5 HIS A 419
HIS A 379
HIS A 223
HIS A 252
HIS A 227
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
 1.37A 5mewA-4yzwA:
undetectable		 5mewA-4yzwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0
(LACCASE 2)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 5 HIS A 419
HIS A 379
HIS A 223
HIS A 252
HIS A 227
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
 1.37A 5mhuA-4yzwA:
undetectable		 5mhuA-4yzwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0
(LACCASE 2)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 5 HIS A 419
HIS A 379
HIS A 223
HIS A 252
HIS A 227
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
 1.37A 5mhvA-4yzwA:
undetectable		 5mhvA-4yzwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 12 ASP A 537
ARG A 270
ILE A 414
PHE A 415
ILE A 422
 None
None
None
CU  A 802 ( 4.9A)
None
 1.18A 5vc0A-4yzwA:
undetectable		 5vc0A-4yzwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 11 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 384
PRO A 101
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.96A 5z0fA-4yzwA:
9.2
5z0fB-4yzwA:
undetectable		 5z0fA-4yzwA:
7.50
5z0fB-4yzwA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 11 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 384
PRO A 101
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.92A 5z0gA-4yzwA:
6.2
5z0gB-4yzwA:
undetectable		 5z0gA-4yzwA:
7.50
5z0gB-4yzwA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 11 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 384
PRO A 101
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.90A 5z0hA-4yzwA:
9.1
5z0hB-4yzwA:
undetectable		 5z0hA-4yzwA:
7.50
5z0hB-4yzwA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 11 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 384
PRO A 101
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.89A 5z0iA-4yzwA:
9.1
5z0iB-4yzwA:
undetectable		 5z0iA-4yzwA:
7.50
5z0iB-4yzwA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 11 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 384
PRO A 101
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.90A 5z0jA-4yzwA:
9.1
5z0jB-4yzwA:
undetectable		 5z0jA-4yzwA:
7.50
5z0jB-4yzwA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 11 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 384
PRO A 101
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.79A 5z0kA-4yzwA:
8.8
5z0kB-4yzwA:
undetectable		 5z0kA-4yzwA:
7.50
5z0kB-4yzwA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 11 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 384
PRO A 101
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.84A 5z0lA-4yzwA:
8.9
5z0lB-4yzwA:
undetectable		 5z0lA-4yzwA:
7.50
5z0lB-4yzwA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 11 HIS A 379
HIS A 252
HIS A 223
VAL A 402
ASP A 412
 CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
None
None
 1.44A 5z0lA-4yzwA:
8.9
5z0lB-4yzwA:
undetectable		 5z0lA-4yzwA:
7.50
5z0lB-4yzwA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		7 / 11 HIS A 223
HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 384
PRO A 101
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 1.00A 5z0mA-4yzwA:
9.2
5z0mB-4yzwA:
undetectable		 5z0mA-4yzwA:
7.50
5z0mB-4yzwA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		5 / 11 HIS A 379
HIS A 252
HIS A 223
VAL A 402
ASP A 412
 CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
None
None
 1.37A 5z0mA-4yzwA:
9.2
5z0mB-4yzwA:
undetectable		 5z0mA-4yzwA:
7.50
5z0mB-4yzwA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 HIS A 379
HIS A 383
HIS A 419
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 802 (-3.1A)
 0.20A 5zrdA-4yzwA:
undetectable		 5zrdA-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 HIS A 223
HIS A 227
PHE A 248
HIS A 252
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
None
CU  A 801 (-3.2A)
 0.68A 5zrdB-4yzwA:
6.7		 5zrdB-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 HIS A 379
HIS A 383
PHE A 415
HIS A 419
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 802 ( 4.9A)
CU  A 802 (-3.1A)
 0.23A 5zrdB-4yzwA:
6.7		 5zrdB-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 HIS A 419
HIS A 379
PHE A  99
HIS A 383
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
 1.05A 5zrdB-4yzwA:
6.7		 5zrdB-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 HIS A 223
HIS A 227
HIS A 252
PHE A 415
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
CU  A 802 ( 4.9A)
 0.76A 5zrdB-4yzwA:
6.7		 5zrdB-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 HIS A 379
HIS A 383
HIS A 419
PHE A 248
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 802 (-3.1A)
None
 1.04A 5zrdB-4yzwA:
6.7		 5zrdB-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 HIS A 383
HIS A 419
HIS A 379
PHE A  99
 CU  A 802 (-3.2A)
CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
None
 1.24A 5zrdB-4yzwA:
6.7		 5zrdB-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 HIS A 223
HIS A 227
HIS A 252
PHE A 415
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
CU  A 802 ( 4.9A)
 0.84A 5zrdC-4yzwA:
2.4		 5zrdC-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 HIS A 379
HIS A 383
HIS A 419
PHE A 248
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 802 (-3.1A)
None
 1.08A 5zrdC-4yzwA:
2.4		 5zrdC-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 HIS A 383
HIS A 419
HIS A 379
PHE A  99
 CU  A 802 (-3.2A)
CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
None
 1.27A 5zrdC-4yzwA:
2.4		 5zrdC-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 HIS A 223
HIS A 227
HIS A 252
PHE A 415
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
CU  A 802 ( 4.9A)
 0.76A 5zrdD-4yzwA:
5.1		 5zrdD-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 HIS A 379
HIS A 383
HIS A 419
PHE A 248
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 802 (-3.1A)
None
 1.05A 5zrdD-4yzwA:
5.1		 5zrdD-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		4 / 5 HIS A 383
HIS A 419
HIS A 379
PHE A  99
 CU  A 802 (-3.2A)
CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
None
 1.22A 5zrdD-4yzwA:
5.1		 5zrdD-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4yzw AGAP004976-PA
(Anopheles
gambiae) 		3 / 3 ASP A 315
LEU A 317
ARG A 104
 None
 0.86A 7dfrA-4yzwA:
undetectable		 7dfrA-4yzwA:
14.22