SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yzz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.25A 1p6kA-4yzzA:
0.6		 1p6kA-4yzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.25A 1p6kB-4yzzA:
undetectable		 1p6kB-4yzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.21A 1rs7B-4yzzA:
undetectable		 1rs7B-4yzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.26A 1zzqA-4yzzA:
undetectable		 1zzqA-4yzzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.26A 1zzqB-4yzzA:
undetectable		 1zzqB-4yzzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.18A 1zzuA-4yzzA:
undetectable		 1zzuA-4yzzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.26A 1zzuB-4yzzA:
undetectable		 1zzuB-4yzzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		3 / 3 ASN A  96
TYR A 142
SER A  89
 None
 0.83A 2gvcB-4yzzA:
undetectable		 2gvcB-4yzzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		3 / 3 ASN A  96
TYR A 142
SER A  89
 None
 0.79A 2gvcE-4yzzA:
undetectable		 2gvcE-4yzzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 ILE A 183
GLY A 184
LEU A 188
LEU A 191
 None
 0.87A 2vctA-4yzzA:
undetectable		 2vctA-4yzzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 6 GLY A  51
HIS A  97
CYH A 152
TRP A  42
 None
 1.29A 3ai8B-4yzzA:
undetectable		 3ai8B-4yzzA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		3 / 3 ASP A 113
LEU A 110
GLN A 197
 None
 0.56A 3g4lA-4yzzA:
undetectable		 3g4lA-4yzzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.24A 3n62A-4yzzA:
undetectable		 3n62A-4yzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.26A 3n62B-4yzzA:
undetectable		 3n62B-4yzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.28A 3n66B-4yzzA:
undetectable		 3n66B-4yzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 12 ILE A  49
VAL A  88
ILE A 147
ILE A 247
ALA A  53
 None
 1.12A 3ohtA-4yzzA:
undetectable
3ohtB-4yzzA:
undetectable		 3ohtA-4yzzA:
21.61
3ohtB-4yzzA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 VAL A 311
LEU A 191
LEU A 188
ILE A 167
 None
 0.85A 3u5kD-4yzzA:
undetectable		 3u5kD-4yzzA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_B_MIYB391_1
(TETX2 PROTEIN)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 11 MET A 102
ASN A  96
HIS A  97
PRO A  43
GLY A  76
 None
 1.44A 4a99B-4yzzA:
undetectable		 4a99B-4yzzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 7 ILE A 218
GLY A 184
ALA A 245
GLU A 242
 6PC  A 404 (-4.3A)
None
6PC  A 404 ( 3.8A)
None
 0.94A 4g0uB-4yzzA:
undetectable		 4g0uB-4yzzA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 7 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.26A 4kcnB-4yzzA:
undetectable		 4kcnB-4yzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		3 / 3 GLU A 343
ALA A 344
PHE A 347
 None
 0.19A 4v1fA-4yzzA:
undetectable		 4v1fA-4yzzA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		3 / 3 GLU A 343
ALA A 344
PHE A 347
 None
 0.25A 4v1fC-4yzzA:
undetectable		 4v1fC-4yzzA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 12 LEU A 226
ASP A 223
GLY A 219
ILE A  49
THR A  48
 None
 0.93A 4xdrA-4yzzA:
undetectable		 4xdrA-4yzzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 7 PHE A 303
ILE A 167
PHE A 241
GLY A 161
 None
 0.94A 4zdzA-4yzzA:
undetectable		 4zdzA-4yzzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 6 ASP A 223
TRP A 217
TYR A 221
THR A  48
 None
 1.44A 5b6iB-4yzzA:
undetectable		 5b6iB-4yzzA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 12 GLY A 105
GLU A 140
PHE A 112
ILE A 147
MET A  85
 None
 1.13A 5igyA-4yzzA:
undetectable		 5igyA-4yzzA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 12 GLY A 243
GLY A 115
ASN A 154
SER A 246
VAL A 157
 None
 1.16A 5kpcB-4yzzA:
undetectable		 5kpcB-4yzzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 11 ALA A 289
GLY A 297
GLY A 296
ALA A 295
TYR A 235
 None
 0.90A 5lf3K-4yzzA:
undetectable
5lf3L-4yzzA:
undetectable		 5lf3K-4yzzA:
22.07
5lf3L-4yzzA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 11 ALA A 289
GLY A 297
GLY A 296
ALA A 295
TYR A 235
 None
 0.91A 5lf3Y-4yzzA:
undetectable
5lf3Z-4yzzA:
undetectable		 5lf3Y-4yzzA:
22.07
5lf3Z-4yzzA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.27A 5vunB-4yzzA:
undetectable		 5vunB-4yzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.30A 5vuoB-4yzzA:
undetectable		 5vuoB-4yzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 9 GLY A  61
TYR A 263
VAL A  60
ASP A  65
GLY A  66
 None
 1.10A 5zniA-4yzzA:
undetectable		 5zniA-4yzzA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLN A 264
PHE A 267
ASN A 149
TRP A 256
 None
 1.29A 6auuB-4yzzA:
undetectable		 6auuB-4yzzA:
20.14