SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z07'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		3 / 3 VAL A 157
VAL A 155
TRP A 205
 None
 0.66A 1bdwA-4z07A:
undetectable
1bdwB-4z07A:
undetectable		 1bdwA-4z07A:
5.19
1bdwB-4z07A:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 PCG  A 401 ( 4.1A)
PCG  A 401 (-3.8A)
None
None
None
PCG  A 401 (-2.8A)
 1.32A 1cd2A-4z07A:
undetectable		 1cd2A-4z07A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 0.94A 1cd2A-4z07A:
undetectable		 1cd2A-4z07A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 0.99A 1dyrA-4z07A:
undetectable		 1dyrA-4z07A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 8 PHE A 305
VAL A 326
THR A 255
VAL A 330
 None
 1.09A 1dz9A-4z07A:
undetectable		 1dz9A-4z07A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.14A 1j3jA-4z07A:
undetectable		 1j3jA-4z07A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 8 PHE A 305
VAL A 326
THR A 255
VAL A 330
 None
 1.12A 1o76B-4z07A:
undetectable		 1o76B-4z07A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.00A 1ra2A-4z07A:
undetectable		 1ra2A-4z07A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 194
LEU A 204
ILE A 145
THR A 193
 PCG  A 401 ( 4.1A)
PCG  A 401 (-3.8A)
None
None
PCG  A 401 (-2.8A)
 1.14A 1rb2B-4z07A:
undetectable		 1rb2B-4z07A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.06A 1rb2B-4z07A:
undetectable		 1rb2B-4z07A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.03A 1re7A-4z07A:
undetectable		 1re7A-4z07A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 0.98A 1rx2A-4z07A:
undetectable		 1rx2A-4z07A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.09A 2blaA-4z07A:
undetectable		 2blaA-4z07A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 LYS A 197
LYS A 167
LEU A 172
GLU A 164
 None
PCG  A 401 ( 4.5A)
PCG  A 401 (-3.9A)
None
 1.13A 3h5gB-4z07A:
undetectable
3h5gC-4z07A:
undetectable		 3h5gB-4z07A:
8.27
3h5gC-4z07A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 4 ILE A 264
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
None
None
PCG  A 402 (-2.7A)
 1.02A 3ia4A-4z07A:
undetectable		 3ia4A-4z07A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.10A 3qgtA-4z07A:
undetectable		 3qgtA-4z07A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.10A 3qgtB-4z07A:
undetectable		 3qgtB-4z07A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 9 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.07A 3tq8A-4z07A:
undetectable		 3tq8A-4z07A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.03A 4g8zX-4z07A:
undetectable		 4g8zX-4z07A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.00A 4kjlA-4z07A:
undetectable		 4kjlA-4z07A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.03A 4km0A-4z07A:
undetectable		 4km0A-4z07A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.03A 4km0B-4z07A:
undetectable		 4km0B-4z07A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 194
LEU A 204
ILE A 145
THR A 193
 PCG  A 401 ( 4.1A)
PCG  A 401 (-3.8A)
None
None
PCG  A 401 (-2.8A)
 0.99A 4km2A-4z07A:
undetectable		 4km2A-4z07A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 194
LEU A 204
ILE A 145
THR A 193
 PCG  A 401 ( 4.1A)
PCG  A 401 (-3.8A)
None
None
PCG  A 401 (-2.8A)
 1.09A 4km2B-4z07A:
undetectable		 4km2B-4z07A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 0.96A 4km2B-4z07A:
undetectable		 4km2B-4z07A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 ILE A 146
ALA A 194
LEU A 204
ILE A 145
THR A 193
 PCG  A 401 ( 4.1A)
PCG  A 401 (-3.8A)
None
None
PCG  A 401 (-2.8A)
 1.17A 4p66A-4z07A:
undetectable		 4p66A-4z07A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 0.97A 4ptjA-4z07A:
undetectable		 4ptjA-4z07A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.05A 4x5jA-4z07A:
undetectable		 4x5jA-4z07A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 187
LEU A  96
ILE A 207
ILE A 130
MET A 216
 None
 1.20A 4y0pA-4z07A:
undetectable		 4y0pA-4z07A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.05A 5e8qA-4z07A:
undetectable		 5e8qA-4z07A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 GLY A 182
VAL A 163
THR A 198
ALA A 206
LEU A 204
 PCG  A 401 (-3.4A)
None
None
None
None
 1.09A 5kocA-4z07A:
undetectable		 5kocA-4z07A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 PCG  A 401 ( 4.1A)
PCG  A 401 (-3.8A)
None
None
None
PCG  A 401 (-2.8A)
 1.38A 5z6jA-4z07A:
undetectable		 5z6jA-4z07A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 0.98A 5z6jA-4z07A:
undetectable		 5z6jA-4z07A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 0.99A 5z6kA-4z07A:
undetectable		 5z6kA-4z07A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 ILE A 146
ALA A 194
LEU A 204
ILE A 145
THR A 193
 PCG  A 401 ( 4.1A)
PCG  A 401 (-3.8A)
None
None
PCG  A 401 (-2.8A)
 1.01A 5z6mA-4z07A:
undetectable		 5z6mA-4z07A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.07A 5z6mA-4z07A:
undetectable		 5z6mA-4z07A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 PCG  A 401 ( 4.1A)
PCG  A 401 (-3.8A)
None
None
None
PCG  A 401 (-2.8A)
 1.34A 7dfrA-4z07A:
undetectable		 7dfrA-4z07A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4z07 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 PCG  A 402 ( 4.0A)
PCG  A 402 (-4.0A)
None
None
PCG  A 402 (-2.7A)
 1.02A 7dfrA-4z07A:
undetectable		 7dfrA-4z07A:
19.62