SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z0c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 8 LEU A 446
PHE A 448
LEU A 473
LEU A 470
 None
 0.84A 1e7cA-4z0cA:
undetectable		 1e7cA-4z0cA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 6 LEU A 217
ASP A 212
LEU A 226
HIS A 222
 None
 1.09A 1errB-4z0cA:
undetectable		 1errB-4z0cA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		3 / 3 GLN A 698
ILE A 710
HIS A 714
 None
 0.47A 1fm9A-4z0cA:
undetectable		 1fm9A-4z0cA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 LEU A 156
PHE A 147
LEU A 176
ILE A 139
VAL A 166
 None
 1.29A 1hrkB-4z0cA:
undetectable		 1hrkB-4z0cA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		3 / 3 GLN A 698
ILE A 710
HIS A 714
 None
 0.48A 1k74A-4z0cA:
undetectable		 1k74A-4z0cA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 ILE A 650
GLY A 627
GLY A 602
ILE A 607
GLU A 679
 None
None
None
None
A  B   7 ( 3.6A)
 1.05A 1nv8B-4z0cA:
undetectable		 1nv8B-4z0cA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 11 LEU A 129
ASN A 161
ILE A 139
LEU A 118
PHE A 147
 None
 1.27A 1tw4A-4z0cA:
undetectable		 1tw4A-4z0cA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 ILE A 650
GLY A 627
GLY A 602
ILE A 607
GLU A 679
 None
None
None
None
A  B   7 ( 3.6A)
 1.03A 1vq1B-4z0cA:
undetectable		 1vq1B-4z0cA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 PHE A 589
LEU A 626
ILE A 607
ILE A 576
PHE A 614
 None
 0.89A 1xdkB-4z0cA:
undetectable		 1xdkB-4z0cA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 PHE A 589
LEU A 626
ILE A 607
ILE A 576
PHE A 614
 None
 0.89A 1xdkF-4z0cA:
undetectable		 1xdkF-4z0cA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 LEU A 156
PHE A 147
LEU A 176
ILE A 139
VAL A 166
 None
 1.22A 2hrcA-4z0cA:
undetectable		 2hrcA-4z0cA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 LEU A 156
PHE A 147
LEU A 176
ILE A 139
VAL A 166
 None
 1.22A 2hrcB-4z0cA:
undetectable		 2hrcB-4z0cA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 5 LEU A 217
ASP A 212
LEU A 226
HIS A 222
 None
 1.13A 2jfaA-4z0cA:
undetectable		 2jfaA-4z0cA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 LEU A 156
PHE A 147
LEU A 176
ILE A 139
VAL A 166
 None
 1.25A 2pnjB-4z0cA:
undetectable		 2pnjB-4z0cA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 5 LEU A 217
ASP A 212
LEU A 226
HIS A 222
 None
 1.06A 2qxsA-4z0cA:
undetectable		 2qxsA-4z0cA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 5 LEU A 217
ASP A 212
LEU A 226
HIS A 222
 None
 1.05A 2qxsB-4z0cA:
undetectable		 2qxsB-4z0cA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 5 PHE A 464
SER A 487
PHE A 432
ILE A 483
 None
 1.39A 2v0mD-4z0cA:
undetectable		 2v0mD-4z0cA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 8 SER A 397
THR A 351
LEU A 319
THR A 423
 None
 1.18A 2v0zO-4z0cA:
undetectable		 2v0zO-4z0cA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		6 / 11 SER A 276
ALA A 277
LEU A 342
LEU A 308
SER A 278
LEU A 301
 NAG  A 907 ( 4.6A)
None
None
None
NAG  A 907 (-3.5A)
None
 1.49A 2xn5A-4z0cA:
undetectable		 2xn5A-4z0cA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 5 PHE A 488
PHE A 491
LEU A 467
PHE A 440
 None
 1.22A 2y69P-4z0cA:
undetectable
2y69W-4z0cA:
undetectable		 2y69P-4z0cA:
16.31
2y69W-4z0cA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 6 LEU A 301
GLY A 303
LEU A 299
SER A 298
 None
None
None
NAG  A 906 (-2.3A)
 0.79A 3aiaA-4z0cA:
undetectable		 3aiaA-4z0cA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 LEU A 156
PHE A 147
LEU A 176
ILE A 139
VAL A 166
 None
 1.26A 3aqiB-4z0cA:
undetectable		 3aqiB-4z0cA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 7 LEU A 666
VAL A 610
LEU A 624
LEU A 683
 None
 0.92A 3g8iA-4z0cA:
undetectable		 3g8iA-4z0cA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 7 LEU A 678
GLN A 638
LEU A 621
LEU A 673
 None
 0.93A 3g8iA-4z0cA:
undetectable		 3g8iA-4z0cA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 6 LEU A  94
ASN A 137
SER A 122
PHE A 147
 None
 1.50A 3i9jB-4z0cA:
undetectable		 3i9jB-4z0cA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 7 SER A 390
LEU A 425
ILE A 364
PHE A 392
 None
 0.98A 3ln1C-4z0cA:
undetectable		 3ln1C-4z0cA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 8 LEU A 352
THR A 359
VAL A 358
LEU A 334
 None
 0.69A 3uniB-4z0cA:
undetectable		 3uniB-4z0cA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 ILE A 186
ILE A 210
ALA A 219
LEU A 203
LEU A 229
 None
 1.01A 3uvvA-4z0cA:
undetectable		 3uvvA-4z0cA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		3 / 3 THR A 232
ASN A 233
GLU A 255
 NAG  A 905 ( 3.9A)
NAG  A 905 (-1.7A)
NAG  A 907 (-2.8A)
 0.81A 3v4tA-4z0cA:
undetectable
3v4tC-4z0cA:
undetectable		 3v4tA-4z0cA:
18.57
3v4tC-4z0cA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 LEU A 156
PHE A 147
LEU A 176
ILE A 139
VAL A 166
 None
 1.25A 3w1wA-4z0cA:
undetectable		 3w1wA-4z0cA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 LEU A 156
PHE A 147
LEU A 176
ILE A 139
VAL A 166
 None
 1.26A 3w1wB-4z0cA:
undetectable		 3w1wB-4z0cA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 7 LEU A 367
GLN A 366
PHE A 354
LEU A 352
 None
 0.96A 3x2qC-4z0cA:
undetectable
3x2qJ-4z0cA:
undetectable		 3x2qC-4z0cA:
16.31
3x2qJ-4z0cA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 7 LEU A 367
GLN A 366
PHE A 354
LEU A 352
 None
 0.96A 3x2qP-4z0cA:
undetectable
3x2qW-4z0cA:
undetectable		 3x2qP-4z0cA:
16.31
3x2qW-4z0cA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 8 PHE A 254
ALA A 277
LEU A 290
LEU A 296
 None
 0.94A 4ejgB-4z0cA:
undetectable		 4ejgB-4z0cA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 6 ARG A 279
GLY A 303
ASN A 282
GLN A 380
 NAG  A 905 ( 3.9A)
None
None
None
 1.14A 4g0vB-4z0cA:
undetectable		 4g0vB-4z0cA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 ALA A 277
HIS A 341
LEU A 319
LEU A 349
GLY A 344
 None
 0.82A 4l9qB-4z0cA:
undetectable		 4l9qB-4z0cA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 6 ILE A 142
ILE A 186
PHE A 170
LEU A 179
 NAG  A 904 (-4.5A)
None
None
None
 0.97A 4m51A-4z0cA:
undetectable		 4m51A-4z0cA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		3 / 3 ARG A 453
HIS A 429
SER A 452
 None
 0.99A 4mjwA-4z0cA:
undetectable
4mjwB-4z0cA:
undetectable		 4mjwA-4z0cA:
19.19
4mjwB-4z0cA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 8 GLY A 379
GLN A 380
SER A 302
ASN A 381
 None
None
NAG  A 907 ( 4.5A)
None
 1.03A 4wryA-4z0cA:
undetectable		 4wryA-4z0cA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 8 GLY A 379
GLN A 380
SER A 302
ASN A 381
 None
None
NAG  A 907 ( 4.5A)
None
 1.01A 4wrzA-4z0cA:
undetectable		 4wrzA-4z0cA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 LEU A 203
LEU A 205
LEU A 156
ILE A 163
VAL A 166
 None
None
None
NAG  A 904 ( 4.2A)
None
 0.92A 4y0rA-4z0cA:
undetectable		 4y0rA-4z0cA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		6 / 10 SER A 276
LEU A 342
LEU A 308
SER A 278
LEU A 301
LEU A 334
 NAG  A 907 ( 4.6A)
None
None
NAG  A 907 (-3.5A)
None
None
 1.45A 4yiaA-4z0cA:
undetectable		 4yiaA-4z0cA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 10 SER A 302
LEU A 349
LEU A 343
LEU A 324
LEU A 367
 NAG  A 907 ( 4.5A)
None
None
None
None
 1.16A 4yiaA-4z0cA:
undetectable		 4yiaA-4z0cA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 4 LEU A 571
ILE A 576
PRO A 588
LEU A 559
 None
 1.08A 5eb3A-4z0cA:
undetectable		 5eb3A-4z0cA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 GLY A 652
GLY A 606
GLY A 602
GLY A 627
LYS A 575
 G  B   8 ( 4.6A)
None
None
None
None
 0.89A 5ehiA-4z0cA:
undetectable		 5ehiA-4z0cA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 GLY A 652
GLY A 606
GLY A 602
GLY A 627
LYS A 575
 G  B   8 ( 4.6A)
None
None
None
None
 0.90A 5eiwA-4z0cA:
undetectable		 5eiwA-4z0cA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 GLY A 652
GLY A 606
GLY A 602
GLY A 627
LYS A 575
 G  B   8 ( 4.6A)
None
None
None
None
 0.91A 5ekxA-4z0cA:
undetectable		 5ekxA-4z0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 GLY A 363
LYS A 365
GLN A 355
LEU A 403
LEU A 384
 None
 1.25A 5nwwA-4z0cA:
undetectable		 5nwwA-4z0cA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 6 PRO A 641
PRO A 587
PHE A 589
LEU A 584
 None
 0.98A 5tl8A-4z0cA:
undetectable		 5tl8A-4z0cA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 7 SER A 612
THR A 583
PRO A 587
ILE A 590
 None
 1.15A 5vkqA-4z0cA:
undetectable
5vkqB-4z0cA:
undetectable		 5vkqA-4z0cA:
17.94
5vkqB-4z0cA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 8 SER A 612
THR A 583
PRO A 587
ILE A 590
 None
 1.13A 5vkqB-4z0cA:
undetectable
5vkqC-4z0cA:
undetectable		 5vkqB-4z0cA:
17.94
5vkqC-4z0cA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 7 SER A 612
THR A 583
PRO A 587
ILE A 590
 None
 1.14A 5vkqC-4z0cA:
undetectable
5vkqD-4z0cA:
undetectable		 5vkqC-4z0cA:
17.94
5vkqD-4z0cA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 GLY A 652
GLY A 606
GLY A 602
GLY A 627
LYS A 575
 G  B   8 ( 4.6A)
None
None
None
None
 0.92A 5wz1B-4z0cA:
undetectable		 5wz1B-4z0cA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 GLY A 652
GLY A 606
GLY A 602
GLY A 627
LYS A 575
 G  B   8 ( 4.6A)
None
None
None
None
 0.93A 5wz2C-4z0cA:
undetectable		 5wz2C-4z0cA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 LEU A 697
PHE A 667
GLU A 679
THR A 653
GLY A 652
 None
None
A  B   7 ( 3.6A)
None
G  B   8 ( 4.6A)
 1.21A 5xiqA-4z0cA:
undetectable		 5xiqA-4z0cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 LEU A 697
PHE A 667
GLU A 679
THR A 653
GLY A 652
 None
None
A  B   7 ( 3.6A)
None
G  B   8 ( 4.6A)
 1.18A 5xiqD-4z0cA:
undetectable		 5xiqD-4z0cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		4 / 8 ILE A 364
ASN A 430
LEU A 376
LEU A 427
 None
 0.86A 5y7pE-4z0cA:
undetectable		 5y7pE-4z0cA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		3 / 3 GLN A 698
ILE A 710
HIS A 714
 None
 0.48A 5z12B-4z0cA:
undetectable		 5z12B-4z0cA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4z0c TOLL-LIKE RECEPTOR
13
(Mus
musculus) 		5 / 12 LEU A 697
PHE A 667
GLU A 679
THR A 653
GLY A 652
 None
None
A  B   7 ( 3.6A)
None
G  B   8 ( 4.6A)
 1.23A 6mn8A-4z0cA:
undetectable		 6mn8A-4z0cA:
20.39