SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		4 / 7 ASN O 313
TYR O 317
ASN O 152
TYR O 311
 NAD  O 401 (-3.8A)
NAD  O 401 (-3.7A)
None
None
 0.94A 1dssG-4z0hO:
52.0		 1dssG-4z0hO:
69.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		7 / 7 SER O 148
THR O 150
ASN O 152
CYH O 153
TYR O 311
ASN O 313
TYR O 317
 SO4  O 403 (-2.8A)
SO4  O 403 (-4.0A)
None
None
None
NAD  O 401 (-3.8A)
NAD  O 401 (-3.7A)
 0.19A 1dssG-4z0hO:
52.0		 1dssG-4z0hO:
69.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		4 / 8 ASN O 313
TYR O 317
ASN O 152
TYR O 311
 NAD  O 401 (-3.8A)
NAD  O 401 (-3.7A)
None
None
 0.93A 1dssR-4z0hO:
51.8		 1dssR-4z0hO:
69.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		8 / 8 SER O 148
THR O 150
ASN O 152
CYH O 153
HIS O 176
TYR O 311
ASN O 313
TYR O 317
 SO4  O 403 (-2.8A)
SO4  O 403 (-4.0A)
None
None
None
None
NAD  O 401 (-3.8A)
NAD  O 401 (-3.7A)
 0.30A 1dssR-4z0hO:
51.8		 1dssR-4z0hO:
69.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		4 / 8 ASN O 313
TYR O 317
ASN O 152
TYR O 311
 NAD  O 401 (-3.8A)
NAD  O 401 (-3.7A)
None
None
 0.95A 3dmtC-4z0hO:
48.5		 3dmtC-4z0hO:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		8 / 8 SER O 148
THR O 150
ASN O 152
CYH O 153
HIS O 176
TYR O 311
ASN O 313
TYR O 317
 SO4  O 403 (-2.8A)
SO4  O 403 (-4.0A)
None
None
None
None
NAD  O 401 (-3.8A)
NAD  O 401 (-3.7A)
 0.25A 3dmtC-4z0hO:
48.5		 3dmtC-4z0hO:
55.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		5 / 12 TYR O 311
ASN O 222
GLY O 209
ALA O 210
GLY O 215
 None
None
SO4  O 403 (-3.9A)
SO4  O 403 ( 3.8A)
None
 0.93A 3hs6B-4z0hO:
undetectable		 3hs6B-4z0hO:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		5 / 12 ILE O   1
VAL O 117
ILE O  11
VAL O  15
VAL O  19
 None
None
NAD  O 401 (-4.1A)
None
None
 0.99A 3iw1A-4z0hO:
undetectable		 3iw1A-4z0hO:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		3 / 3 GLU O 134
LEU O 324
ASP O 323
 None
 0.38A 3ko0A-4z0hO:
undetectable		 3ko0A-4z0hO:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		3 / 3 GLU O 134
LEU O 324
ASP O 323
 None
 0.36A 3ko0T-4z0hO:
undetectable		 3ko0T-4z0hO:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		5 / 12 ALA O 211
LEU O 307
PHE O 292
THR O 151
LEU O 154
 None
None
None
SO4  O 403 ( 4.4A)
None
 1.06A 3p2kA-4z0hO:
4.2		 3p2kA-4z0hO:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		4 / 5 GLY O 316
ASP O 312
ARG O 288
GLN O  21
 None
 1.47A 3qx3A-4z0hO:
undetectable		 3qx3A-4z0hO:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		4 / 5 GLY O 316
ASP O 312
ARG O 288
GLN O  21
 None
 1.49A 3qx3B-4z0hO:
undetectable		 3qx3B-4z0hO:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		4 / 6 THR O  96
ASN O   6
ASP O  32
ILE O  35
 NAD  O 401 (-4.3A)
NAD  O 401 (-3.8A)
NAD  O 401 (-2.8A)
None
 1.33A 3w9tB-4z0hO:
undetectable		 3w9tB-4z0hO:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		5 / 12 TYR O 311
ASN O 222
GLY O 209
ALA O 210
GLY O 215
 None
None
SO4  O 403 (-3.9A)
SO4  O 403 ( 3.8A)
None
 0.88A 4e1gA-4z0hO:
undetectable		 4e1gA-4z0hO:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		4 / 7 VAL O 305
LEU O 307
ALA O 299
LEU O 246
 None
 0.51A 5jq7A-4z0hO:
undetectable		 5jq7A-4z0hO:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		5 / 12 SER O 207
ALA O 213
TYR O 311
ALA O 210
GLY O 209
 None
None
None
SO4  O 403 ( 3.8A)
SO4  O 403 (-3.9A)
 1.07A 5tzoB-4z0hO:
undetectable		 5tzoB-4z0hO:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC
(Arabidopsis
thaliana) 		4 / 8 GLY O  12
ILE O  11
ASP O  47
HIS O  50
 None
NAD  O 401 (-4.1A)
None
None
 0.94A 6ag0A-4z0hO:
undetectable		 6ag0A-4z0hO:
13.99