SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4z0m ENOYL-COA HYDRATASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 113
LEU A  92
MET A  91
 None
 0.77A 2itzA-4z0mA:
undetectable		 2itzA-4z0mA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4z0m ENOYL-COA HYDRATASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 117
LEU A  92
MET A  91
 None
 0.84A 2itzA-4z0mA:
undetectable		 2itzA-4z0mA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4z0m ENOYL-COA HYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  53
LEU A  18
VAL A   5
PRO A  87
GLY A  86
 None
 1.08A 2vmyA-4z0mA:
undetectable		 2vmyA-4z0mA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4z0m ENOYL-COA HYDRATASE
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 111
GLY A 107
LEU A  18
VAL A  16
ALA A  64
PRO A  87
 None
 1.39A 2vmyA-4z0mA:
undetectable		 2vmyA-4z0mA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4z0m ENOYL-COA HYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 111
LEU A  18
VAL A  16
ASN A  75
PRO A  87
 None
 1.08A 2vmyA-4z0mA:
undetectable		 2vmyA-4z0mA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4z0m ENOYL-COA HYDRATASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  53
VAL A  16
LEU A  92
ASP A  45
 None
 0.88A 3cs9D-4z0mA:
undetectable		 3cs9D-4z0mA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 4z0m ENOYL-COA HYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  57
SER A 101
ALA A  99
ALA A  98
CYH A 115
 None
 0.82A 3keeA-4z0mA:
undetectable		 3keeA-4z0mA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4z0m ENOYL-COA HYDRATASE
(Mycobacterium
tuberculosis) 		3 / 3 SER A  23
ASP A  65
ASN A  75
 None
 0.96A 3lslA-4z0mA:
undetectable
3lslD-4z0mA:
undetectable		 3lslA-4z0mA:
22.84
3lslD-4z0mA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4z0m ENOYL-COA HYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  57
SER A 101
ALA A  99
ALA A  98
CYH A 115
 None
 0.91A 3sufD-4z0mA:
undetectable		 3sufD-4z0mA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4z0m ENOYL-COA HYDRATASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 120
PHE A 126
ALA A 104
ALA A  98
 None
 0.79A 4du2A-4z0mA:
undetectable		 4du2A-4z0mA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4z0m ENOYL-COA HYDRATASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 120
PHE A 126
ALA A 104
ALA A  98
 None
 0.74A 4du2B-4z0mA:
undetectable		 4du2B-4z0mA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 4z0m ENOYL-COA HYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 188
ARG A 204
VAL A  96
ASP A  45
PHE A  42
 None
 1.39A 5vlmD-4z0mA:
undetectable		 5vlmD-4z0mA:
26.07