SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		4 / 6 ALA A 211
LYS A 214
ASP A 218
ALA A 219
 None
 0.23A 1iwhA-4z0nA:
undetectable		 1iwhA-4z0nA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		4 / 7 ASP A 325
GLY A 321
ALA A 265
ILE A 269
 None
 0.77A 1n49A-4z0nA:
undetectable		 1n49A-4z0nA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		4 / 6 GLY A 145
ILE A 142
GLN A 146
VAL A 278
 None
 0.96A 1rs7B-4z0nA:
undetectable		 1rs7B-4z0nA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		4 / 4 GLY A 242
SER A 246
VAL A 256
LEU A 171
 None
 1.15A 1yajB-4z0nA:
3.7		 1yajB-4z0nA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		5 / 9 PRO A 318
VAL A 317
GLY A 134
ILE A 289
GLY A 284
 None
 1.38A 3csjB-4z0nA:
undetectable		 3csjB-4z0nA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		4 / 6 GLY A 145
ILE A 142
GLN A 146
VAL A 278
 None
 0.91A 4d39B-4z0nA:
undetectable		 4d39B-4z0nA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		4 / 6 PHE A  40
ALA A 282
GLY A 134
VAL A 317
 GAL  A 405 (-3.7A)
SO4  A 404 ( 4.7A)
None
None
 0.72A 4dubA-4z0nA:
undetectable		 4dubA-4z0nA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		4 / 7 GLY A 238
ILE A 262
GLU A 264
GLN A 212
 None
SO4  A 404 (-4.3A)
None
None
 1.12A 4g0vA-4z0nA:
2.4		 4g0vA-4z0nA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		4 / 6 GLY A 145
ILE A 142
GLN A 146
VAL A 278
 None
 0.99A 4kcnA-4z0nA:
undetectable		 4kcnA-4z0nA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		4 / 6 ASN A  68
ASP A 209
GLY A 173
PRO A  95
 None
 1.02A 4l1aB-4z0nA:
undetectable		 4l1aB-4z0nA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		4 / 4 ASN A  39
GLY A 238
ASP A  94
ASP A 209
 None
 1.30A 4n49A-4z0nA:
undetectable		 4n49A-4z0nA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		3 / 3 ASN A 116
ASP A  38
ASP A 237
 GAL  A 405 (-2.7A)
GAL  A 405 (-2.0A)
None
 0.74A 4obwD-4z0nA:
undetectable		 4obwD-4z0nA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		5 / 12 GLY A  98
VAL A 101
ILE A 102
LEU A  88
ILE A 296
 None
 1.02A 4pd4C-4z0nA:
undetectable		 4pd4C-4z0nA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		4 / 4 LEU A  88
ILE A 113
GLY A  30
ILE A 289
 None
 0.85A 5dzk3-4z0nA:
undetectable
5dzkm-4z0nA:
undetectable		 5dzk3-4z0nA:
2.99
5dzkm-4z0nA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		4 / 5 ILE A 113
GLY A  30
ILE A 289
LEU A  88
 None
 0.84A 5dzkB-4z0nA:
undetectable
5dzkI-4z0nA:
undetectable
5dzkW-4z0nA:
undetectable		 5dzkB-4z0nA:
21.74
5dzkI-4z0nA:
20.47
5dzkW-4z0nA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		4 / 5 ILE A 113
GLY A  30
ILE A 289
LEU A  88
 None
 0.84A 5dzki-4z0nA:
undetectable
5dzkj-4z0nA:
undetectable
5dzkx-4z0nA:
undetectable		 5dzki-4z0nA:
20.47
5dzkj-4z0nA:
20.47
5dzkx-4z0nA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		4 / 4 ILE A 113
GLY A  30
ILE A 289
LEU A  88
 None
 0.85A 5dzkl-4z0nA:
undetectable
5dzkz-4z0nA:
undetectable		 5dzkl-4z0nA:
20.47
5dzkz-4z0nA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		5 / 9 GLY A  30
THR A  32
LEU A  88
ASN A  82
LEU A  73
 None
NA  A 409 (-3.5A)
None
None
NA  A 409 ( 4.1A)
 1.19A 5fhzB-4z0nA:
2.1		 5fhzB-4z0nA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		5 / 12 GLY A 276
GLY A 141
GLY A 258
LYS A 185
ILE A 142
 None
 0.90A 5m5bA-4z0nA:
undetectable		 5m5bA-4z0nA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Streptobacillus
moniliformis) 		5 / 12 ALA A 243
LEU A 241
THR A 267
ALA A 265
ILE A 262
 None
None
None
None
SO4  A 404 (-4.3A)
 1.09A 5mioB-4z0nA:
4.7		 5mioB-4z0nA:
22.69