SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		4 / 5 LEU A   9
LEU A  11
LEU A 131
LEU A 130
 None
 1.04A 2ab2B-4z0tA:
undetectable		 2ab2B-4z0tA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		4 / 7 VAL A  34
ILE A  78
GLY A  76
ARG A  73
 None
 0.83A 3bjwB-4z0tA:
undetectable		 3bjwB-4z0tA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		4 / 7 VAL A  34
ILE A  78
GLY A  76
ARG A  73
 None
 0.89A 3bjwF-4z0tA:
undetectable		 3bjwF-4z0tA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		4 / 7 VAL A  34
ILE A  78
GLY A  76
ARG A  73
 None
 0.88A 3bjwH-4z0tA:
undetectable		 3bjwH-4z0tA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		5 / 12 GLY A  75
ASP A  72
ILE A  35
LEU A 130
PRO A 129
 None
 1.17A 3eeyD-4z0tA:
9.9		 3eeyD-4z0tA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		5 / 10 LYS A 111
SER A 119
SER A 160
ILE A  94
GLY A  93
 None
 1.29A 3ik6B-4z0tA:
undetectable
3ik6E-4z0tA:
undetectable		 3ik6B-4z0tA:
23.26
3ik6E-4z0tA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		5 / 12 VAL A 185
VAL A 213
ILE A  19
GLY A  20
VAL A  34
 None
None
BR  A 304 (-4.5A)
None
None
 1.02A 4y8wA-4z0tA:
undetectable		 4y8wA-4z0tA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		5 / 12 VAL A 185
VAL A 213
ILE A  19
GLY A  20
VAL A  34
 None
None
BR  A 304 (-4.5A)
None
None
 1.03A 4y8wB-4z0tA:
undetectable		 4y8wB-4z0tA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		5 / 12 SER A 160
ILE A  65
ILE A  94
GLY A  96
VAL A 104
 None
BR  A 305 ( 4.0A)
None
None
None
 1.02A 4y8wC-4z0tA:
undetectable		 4y8wC-4z0tA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		5 / 12 VAL A 185
VAL A 213
ILE A  19
GLY A  20
VAL A  34
 None
None
BR  A 304 (-4.5A)
None
None
 0.99A 4y8wC-4z0tA:
undetectable		 4y8wC-4z0tA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		3 / 3 TYR A 157
TYR A 242
SER A 184
 None
 0.93A 5iktB-4z0tA:
undetectable		 5iktB-4z0tA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		4 / 7 GLY A  93
ALA A  92
GLY A  20
ILE A  19
 None
BR  A 305 (-3.6A)
None
BR  A 304 (-4.5A)
 0.66A 5kqyB-4z0tA:
undetectable		 5kqyB-4z0tA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		4 / 8 GLY A  93
ALA A  92
GLY A  20
ILE A  19
 None
BR  A 305 (-3.6A)
None
BR  A 304 (-4.5A)
 0.64A 5kr1B-4z0tA:
undetectable		 5kr1B-4z0tA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		5 / 12 LEU A  71
LEU A  74
GLY A  75
GLY A  76
LEU A  88
 None
 0.89A 5uc1A-4z0tA:
undetectable		 5uc1A-4z0tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		4 / 7 GLN A 197
GLY A 188
ILE A  19
GLN A 211
 None
None
BR  A 304 (-4.5A)
None
 0.77A 5vlmC-4z0tA:
undetectable		 5vlmC-4z0tA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		4 / 8 GLN A 197
GLY A 188
ILE A  19
GLN A 211
 None
None
BR  A 304 (-4.5A)
None
 0.75A 5vlmD-4z0tA:
undetectable		 5vlmD-4z0tA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		5 / 12 LYS A 181
VAL A  61
LEU A  63
GLY A  75
ILE A  78
 None
 1.16A 5vooB-4z0tA:
3.0		 5vooB-4z0tA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		5 / 12 LYS A 181
VAL A  61
LEU A  63
GLY A  75
ILE A  78
 None
 0.98A 5vooE-4z0tA:
3.3		 5vooE-4z0tA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4z0t OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Brucella
ovis) 		5 / 10 ARG A  73
ALA A  70
LEU A  74
GLY A  75
LEU A  25
 None
 1.42A 6hqbA-4z0tA:
undetectable
6hqbJ-4z0tA:
undetectable		 6hqbA-4z0tA:
13.95
6hqbJ-4z0tA:
11.46