SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z0v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 8 ALA A 476
ASP A 398
ILE A 399
ASP A 408
 None
 0.92A 1p7lD-4z0vA:
undetectable		 1p7lD-4z0vA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 8 ALA A 476
ASP A 398
ILE A 399
ASP A 408
 None
 0.91A 1p7lC-4z0vA:
undetectable		 1p7lC-4z0vA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 8 ALA A 476
ASP A 398
ILE A 399
ASP A 408
 None
 0.93A 1rg9A-4z0vA:
undetectable		 1rg9A-4z0vA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 8 ALA A 476
ASP A 398
ILE A 399
ASP A 408
 None
 0.93A 1rg9D-4z0vA:
1.4		 1rg9D-4z0vA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 8 ALA A 476
ASP A 398
ILE A 399
ASP A 408
 None
 0.93A 1rg9C-4z0vA:
undetectable		 1rg9C-4z0vA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 8 PHE A 177
TYR A 172
TYR A 324
TYR A 330
 None
 1.33A 1xqlA-4z0vA:
undetectable
1xqlB-4z0vA:
undetectable		 1xqlA-4z0vA:
24.04
1xqlB-4z0vA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 8 TYR A 324
TYR A 330
PHE A 177
TYR A 172
 None
 1.29A 1xqlA-4z0vA:
undetectable
1xqlB-4z0vA:
undetectable		 1xqlA-4z0vA:
24.04
1xqlB-4z0vA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		5 / 12 GLY A 464
TYR A 421
LEU A 418
LEU A 534
MET A 532
 None
None
None
GOL  A 707 (-4.2A)
None
 1.30A 1zgyA-4z0vA:
undetectable		 1zgyA-4z0vA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		5 / 10 ALA A 476
GLN A 425
LEU A 429
LEU A 414
LEU A 405
 None
None
None
GOL  A 707 ( 4.0A)
None
 1.16A 2riwA-4z0vA:
undetectable
2riwB-4z0vA:
undetectable		 2riwA-4z0vA:
22.27
2riwB-4z0vA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		5 / 9 ALA A 304
ASP A 353
SER A 360
PHE A 385
LEU A 339
 None
 1.38A 4eilF-4z0vA:
undetectable		 4eilF-4z0vA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 5 SER A 499
ARG A 467
LEU A 457
ASP A 496
 None
GOL  A 706 (-3.7A)
None
None
 1.47A 4ifxA-4z0vA:
0.3		 4ifxA-4z0vA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 5 SER A 499
ARG A 467
LEU A 457
ASP A 496
 None
GOL  A 706 (-3.7A)
None
None
 1.45A 4ig1A-4z0vA:
undetectable		 4ig1A-4z0vA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		5 / 12 ALA A 304
ASP A 353
SER A 360
PHE A 385
LEU A 339
 None
 1.45A 4kyaB-4z0vA:
undetectable		 4kyaB-4z0vA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		5 / 12 ALA A 304
ASP A 353
SER A 360
PHE A 385
LEU A 339
 None
 1.43A 4kyaD-4z0vA:
undetectable		 4kyaD-4z0vA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		5 / 12 ALA A 304
ASP A 353
SER A 360
PHE A 385
LEU A 339
 None
 1.44A 4kyaF-4z0vA:
undetectable		 4kyaF-4z0vA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		5 / 11 ALA A 304
ASP A 353
SER A 360
PHE A 385
LEU A 339
 None
 1.42A 4kyaG-4z0vA:
undetectable		 4kyaG-4z0vA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		5 / 12 ALA A 304
ASP A 353
SER A 360
PHE A 385
LEU A 339
 None
 1.44A 4kyaH-4z0vA:
undetectable		 4kyaH-4z0vA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 8 ALA A 476
ASP A 398
ILE A 399
ASP A 408
 None
 0.89A 4ndnB-4z0vA:
undetectable		 4ndnB-4z0vA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 8 ALA A 476
ASP A 398
ILE A 399
ASP A 408
 None
 0.93A 4ndnD-4z0vA:
undetectable		 4ndnD-4z0vA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 6 VAL A 428
LEU A 429
LEU A 414
PHE A 493
 None
None
GOL  A 707 ( 4.0A)
None
 1.06A 4o1zA-4z0vA:
undetectable		 4o1zA-4z0vA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		8 / 12 LEU A 317
TYR A 318
HIS A 456
PRO A 461
ASP A 496
ASN A 498
PHE A 556
HIS A 599
 None
None
None
GOL  A 706 (-3.9A)
None
GOL  A 706 (-4.8A)
GOL  A 706 ( 4.7A)
None
 0.64A 5dv4A-4z0vA:
39.5		 5dv4A-4z0vA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		3 / 3 GLU A 351
TRP A 459
ASN A 551
 MG  A 701 (-2.4A)
None
None
 0.37A 5dv4A-4z0vA:
39.5		 5dv4A-4z0vA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 6 ASP A 496
HIS A 456
LEU A 560
HIS A 599
 None
 1.01A 5nelB-4z0vA:
undetectable
5nelC-4z0vA:
undetectable		 5nelB-4z0vA:
20.09
5nelC-4z0vA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		3 / 3 HIS A 456
ASP A 496
HIS A 599
 None
 0.79A 5oexB-4z0vA:
undetectable		 5oexB-4z0vA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		3 / 3 HIS A 456
ASP A 496
HIS A 599
 None
 0.77A 5oexD-4z0vA:
0.5		 5oexD-4z0vA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 8 ALA A 476
ASP A 398
ILE A 399
ASP A 408
 None
 0.88A 5t8sA-4z0vA:
undetectable		 5t8sA-4z0vA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 8 THR A 236
TYR A 235
ARG A 233
TRP A 197
 None
 1.07A 5tzoA-4z0vA:
undetectable		 5tzoA-4z0vA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		3 / 3 TYR A 172
ALA A 325
TYR A 330
 None
 0.82A 5uunB-4z0vA:
undetectable		 5uunB-4z0vA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 7 ALA A 476
ASP A 398
ILE A 399
ASP A 408
 None
 0.88A 6fbnA-4z0vA:
undetectable		 6fbnA-4z0vA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4z0v 2',5'-PHOSPHODIESTER
ASE 12
(Homo
sapiens) 		4 / 5 ALA A 344
TYR A 342
GLN A 574
ILE A 576
 None
 1.44A 6g9bA-4z0vA:
undetectable
6g9bB-4z0vA:
undetectable		 6g9bA-4z0vA:
14.49
6g9bB-4z0vA:
11.84