SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z0x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
(Homo
sapiens) 		4 / 8 VAL A 105
ARG A  60
ALA A  18
GLU A  82
 None
 1.11A 1dmiA-4z0xA:
undetectable
1dmiB-4z0xA:
undetectable		 1dmiA-4z0xA:
15.09
1dmiB-4z0xA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
(Homo
sapiens) 		6 / 12 TYR A  35
GLN A  88
PHE A  97
VAL B  62
ALA B 122
TRP B 134
 None
 0.61A 1h8sA-4z0xA:
17.8		 1h8sA-4z0xA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens) 		4 / 4 ALA B 117
ARG B  63
GLN B  64
GLU B  71
 None
 1.38A 1lqtB-4z0xB:
undetectable		 1lqtB-4z0xB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens) 		4 / 4 ALA B 117
ARG B  63
GLN B  64
GLU B  71
 None
 1.36A 1lquB-4z0xB:
undetectable		 1lquB-4z0xB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens) 		5 / 12 HIS B  54
LEU B 126
TYR B 131
THR B  60
ILE B  59
 None
 1.16A 1xoqA-4z0xB:
undetectable		 1xoqA-4z0xB:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens) 		5 / 12 HIS B  54
LEU B 126
TYR B 131
THR B  60
ILE B  59
 None
 1.14A 1xoqB-4z0xB:
undetectable		 1xoqB-4z0xB:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR A  35
PRO A  43
TYR A  86
TYR B 120
 None
 0.66A 2oldA-4z0xA:
19.1
2oldB-4z0xA:
19.0		 2oldA-4z0xA:
57.66
2oldB-4z0xA:
57.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR B 120
TYR A  35
PRO A  43
TYR A  86
 None
 0.72A 2oldA-4z0xB:
11.9
2oldB-4z0xB:
11.9		 2oldA-4z0xB:
21.66
2oldB-4z0xB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens) 		5 / 12 HIS B  54
LEU B 126
TYR B 131
THR B  60
ILE B  59
 None
 1.12A 3g4lC-4z0xB:
undetectable		 3g4lC-4z0xB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		 4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens) 		4 / 7 ASN B  56
PRO B  78
PHE B  76
TYR B 131
 None
 1.36A 4v2yC-4z0xB:
undetectable		 4v2yC-4z0xB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens) 		4 / 8 ASN B  56
PRO B  78
PHE B  76
TYR B 131
 None
 1.35A 4v2zC-4z0xB:
undetectable		 4v2zC-4z0xB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
(Homo
sapiens) 		3 / 3 ASP A  50
LEU A  27
GLY A  28
 None
 0.48A 4xmfA-4z0xA:
undetectable		 4xmfA-4z0xA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
(Homo
sapiens) 		5 / 7 TYR A  31
SER A  33
TYR A  35
TYR A  48
PRO A  54
 None
 0.67A 5aclA-4z0xA:
20.0		 5aclA-4z0xA:
57.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
(Homo
sapiens) 		5 / 12 GLN A  78
TYR A  85
ALA A  18
VAL A  12
LEU A  47
 None
 1.24A 5hv1A-4z0xA:
undetectable		 5hv1A-4z0xA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
(Homo
sapiens) 		4 / 8 THR A  71
SER A  64
THR A  69
SER A  66
 None
 0.86A 5l4eA-4z0xA:
undetectable
5l4eB-4z0xA:
undetectable
5l4eC-4z0xA:
undetectable
5l4eD-4z0xA:
undetectable
5l4eE-4z0xA:
undetectable		 5l4eA-4z0xA:
15.41
5l4eB-4z0xA:
15.41
5l4eC-4z0xA:
15.41
5l4eD-4z0xA:
15.41
5l4eE-4z0xA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens) 		4 / 8 ASN B  56
PRO B  78
PHE B  76
TYR B 131
 None
 1.43A 5oh1C-4z0xB:
undetectable		 5oh1C-4z0xB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 GLY A  24
GLN B  87
ASP A  91
ASP A  29
 None
 1.09A 5vlmE-4z0xA:
undetectable		 5vlmE-4z0xA:
20.21