SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z11'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 6 PHE A 273
HIS A 286
ALA A 276
GLY A 271
 None
CU  A 701 (-3.1A)
None
None
 1.11A 1c8lA-4z11A:
undetectable		 1c8lA-4z11A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 6 PHE A 273
HIS A 286
ALA A 276
GLY A 271
 None
CU  A 701 (-3.1A)
None
None
 1.11A 1gfzA-4z11A:
undetectable		 1gfzA-4z11A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 10 VAL A 259
HIS A 285
HIS A 286
HIS A 252
ALA A 254
 None
None
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
 1.13A 1r55A-4z11A:
undetectable		 1r55A-4z11A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 TYR A 420
THR A 467
GLN A 455
ILE A 418
PHE A 453
 None
 0.98A 2akeA-4z11A:
undetectable		 2akeA-4z11A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 TYR A 420
THR A 467
GLN A 455
ILE A 418
PHE A 453
 None
 0.96A 2azxA-4z11A:
undetectable		 2azxA-4z11A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 TYR A 420
THR A 467
GLN A 455
ILE A 418
PHE A 453
 None
 1.01A 2azxB-4z11A:
undetectable		 2azxB-4z11A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 7 ARG A  27
ASP A 279
ARG A  76
ASP A 269
 None
 1.15A 2e5dA-4z11A:
undetectable
2e5dB-4z11A:
undetectable		 2e5dA-4z11A:
22.64
2e5dB-4z11A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 7 ASP A 269
ARG A  27
ASP A 279
ARG A  76
 None
 1.15A 2e5dA-4z11A:
undetectable
2e5dB-4z11A:
undetectable		 2e5dA-4z11A:
22.64
2e5dB-4z11A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 7 SER A 251
VAL A 255
LEU A 129
ASP A 153
 None
 1.06A 2hdnF-4z11A:
undetectable
2hdnG-4z11A:
undetectable
2hdnH-4z11A:
undetectable		 2hdnF-4z11A:
21.47
2hdnG-4z11A:
6.81
2hdnH-4z11A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 11 LEU A 147
ALA A  57
ILE A 160
PRO A 280
ILE A 284
 None
 0.97A 2idwA-4z11A:
undetectable		 2idwA-4z11A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 HIS A  93
HIS A 116
ILE A 115
HIS A 125
HIS A 286
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
 1.13A 2pgrA-4z11A:
undetectable		 2pgrA-4z11A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A 252
HIS A 256
VAL A 289
HIS A 286
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
CU  A 701 (-3.1A)
 0.94A 2wkoF-4z11A:
undetectable		 2wkoF-4z11A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 ILE A 115
HIS A 252
HIS A 256
HIS A 286
 None
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
 1.03A 3ljgA-4z11A:
undetectable		 3ljgA-4z11A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		3 / 3 HIS A 116
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.15A 3qpkA-4z11A:
undetectable		 3qpkA-4z11A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		3 / 3 HIS A 116
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.14A 3qpkB-4z11A:
undetectable		 3qpkB-4z11A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 ASP A 429
VAL A 430
GLY A 451
ASP A 190
 None
 1.40A 3w9tA-4z11A:
undetectable		 3w9tA-4z11A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 ASP A 429
VAL A 430
GLY A 451
ASP A 190
 None
 1.39A 3w9tB-4z11A:
undetectable		 3w9tB-4z11A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 ASP A 429
VAL A 430
GLY A 451
ASP A 190
 None
 1.40A 3w9tC-4z11A:
undetectable		 3w9tC-4z11A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 ASP A 429
VAL A 430
GLY A 451
ASP A 190
 None
 1.39A 3w9tD-4z11A:
undetectable		 3w9tD-4z11A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 ASP A 429
VAL A 430
GLY A 451
ASP A 190
 None
 1.39A 3w9tE-4z11A:
undetectable		 3w9tE-4z11A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 ASP A 429
VAL A 430
GLY A 451
ASP A 190
 None
 1.39A 3w9tF-4z11A:
undetectable		 3w9tF-4z11A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 ASP A 429
VAL A 430
GLY A 451
ASP A 190
 None
 1.39A 3w9tG-4z11A:
undetectable		 3w9tG-4z11A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 ASP A 429
PHE A 425
ILE A 198
ARG A 496
ASP A 192
 None
 1.23A 3wemA-4z11A:
undetectable		 3wemA-4z11A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 ASP A 429
PHE A 425
ILE A 198
ARG A 496
ASP A 192
 None
 1.20A 3weoA-4z11A:
undetectable		 3weoA-4z11A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		3 / 3 ARG A  76
ARG A  27
ASP A 279
 None
 0.97A 3wipG-4z11A:
undetectable
3wipH-4z11A:
undetectable		 3wipG-4z11A:
17.18
3wipH-4z11A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 GLU A 479
ARG A 401
GLU A 484
ALA A 409
ASN A 410
 None
 1.45A 4cpzB-4z11A:
undetectable		 4cpzB-4z11A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 GLU A 479
ARG A 401
GLU A 484
ALA A 409
ASN A 410
 None
 1.41A 4cpzC-4z11A:
undetectable		 4cpzC-4z11A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 GLU A 479
ARG A 401
GLU A 484
ALA A 409
ASN A 410
 None
 1.42A 4cpzD-4z11A:
undetectable		 4cpzD-4z11A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 GLU A 479
ARG A 401
GLU A 484
ALA A 409
ASN A 410
 None
 1.46A 4cpzG-4z11A:
undetectable		 4cpzG-4z11A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 GLU A 479
ARG A 401
GLU A 484
ALA A 409
ASN A 410
 None
 1.40A 4cpzH-4z11A:
undetectable		 4cpzH-4z11A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 9 GLY A 452
GLY A 451
ARG A 213
PHE A 431
ASP A 429
 None
 1.20A 4h2gA-4z11A:
undetectable		 4h2gA-4z11A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 7 PHE A 124
HIS A 125
PHE A 273
ASN A  98
 None
CU  A 700 (-3.2A)
None
None
 1.31A 4o7gA-4z11A:
undetectable
4o7gB-4z11A:
undetectable		 4o7gA-4z11A:
19.43
4o7gB-4z11A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 6 PHE A 124
HIS A 125
PHE A 273
ASN A  98
 None
CU  A 700 (-3.2A)
None
None
 1.27A 4o7gB-4z11A:
undetectable		 4o7gB-4z11A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 LEU A 413
PHE A 382
VAL A 504
GLY A 505
LEU A 493
 None
 1.36A 4ot2A-4z11A:
undetectable		 4ot2A-4z11A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A  93
HIS A 116
HIS A 252
HIS A 256
ALA A 276
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
 0.48A 4p6sA-4z11A:
19.6		 4p6sA-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A 256
HIS A 252
HIS A 116
HIS A  93
ALA A 276
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 1.12A 4p6sA-4z11A:
19.6		 4p6sA-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A 256
HIS A 252
HIS A 125
HIS A  93
ALA A 276
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 1.50A 4p6sA-4z11A:
19.6		 4p6sA-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A 256
HIS A 286
HIS A 116
HIS A  93
ALA A 276
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 1.44A 4p6sA-4z11A:
19.6		 4p6sA-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A  93
HIS A 116
HIS A 252
HIS A 256
ARG A 257
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
 1.16A 4p6sB-4z11A:
19.7		 4p6sB-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 7 HIS A 116
HIS A  93
HIS A 256
HIS A 252
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
 0.97A 4p6sB-4z11A:
19.7		 4p6sB-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 7 PHE A 472
LEU A 413
LEU A 493
ASP A 429
 None
 0.85A 4rmjA-4z11A:
undetectable		 4rmjA-4z11A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 GLY A 245
HIS A 458
HIS A 256
GLN A 455
ILE A 456
 None
None
CU  A 701 (-3.1A)
None
None
 1.35A 4ypaC-4z11A:
undetectable		 4ypaC-4z11A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 PHE A 225
PHE A 121
PHE A 122
VAL A 247
 None
 1.19A 5a1rA-4z11A:
undetectable		 5a1rA-4z11A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 11 VAL A 394
VAL A 491
VAL A 392
ILE A 418
LEU A 413
 None
 0.97A 5e4dB-4z11A:
undetectable		 5e4dB-4z11A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A  93
HIS A 116
HIS A 252
HIS A 256
ALA A 276
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
 0.42A 5i3aA-4z11A:
19.8		 5i3aA-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A 256
HIS A 252
HIS A 116
HIS A  93
ALA A 276
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 1.11A 5i3aA-4z11A:
19.8		 5i3aA-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A 256
HIS A 252
HIS A 125
HIS A  93
ALA A 276
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 1.46A 5i3aA-4z11A:
19.8		 5i3aA-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A 256
HIS A 286
HIS A 116
HIS A  93
ALA A 276
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 1.49A 5i3aA-4z11A:
19.8		 5i3aA-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A  93
HIS A 116
HIS A 252
HIS A 256
ALA A 276
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
 0.39A 5i3aB-4z11A:
19.7		 5i3aB-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A 256
HIS A 252
HIS A 116
HIS A  93
ALA A 276
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 1.12A 5i3aB-4z11A:
19.7		 5i3aB-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A 256
HIS A 252
HIS A 125
HIS A  93
ALA A 276
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 1.49A 5i3aB-4z11A:
19.7		 5i3aB-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A 256
HIS A 286
HIS A 116
HIS A  93
ALA A 276
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 1.47A 5i3aB-4z11A:
19.7		 5i3aB-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A  93
HIS A 116
HIS A 252
HIS A 256
ALA A 276
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
 0.46A 5i3bA-4z11A:
19.9		 5i3bA-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A 256
HIS A 252
HIS A 116
HIS A  93
ALA A 276
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 1.11A 5i3bA-4z11A:
19.9		 5i3bA-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A 256
HIS A 252
HIS A 125
HIS A  93
ALA A 276
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 1.46A 5i3bA-4z11A:
19.9		 5i3bA-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 7 HIS A 256
HIS A 286
HIS A 116
HIS A  93
ALA A 276
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 1.49A 5i3bA-4z11A:
19.9		 5i3bA-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A  93
HIS A 116
HIS A 256
ALA A 276
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
None
 0.40A 5i3bB-4z11A:
19.8		 5i3bB-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A 256
HIS A 252
HIS A  93
ALA A 276
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
None
 0.97A 5i3bB-4z11A:
19.8		 5i3bB-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A 256
HIS A 286
HIS A  93
ALA A 276
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
None
 0.99A 5i3bB-4z11A:
19.8		 5i3bB-4z11A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 GLU A 248
LEU A 120
GLY A 228
VAL A 231
ASN A 331
 None
 1.38A 5kbwB-4z11A:
undetectable		 5kbwB-4z11A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 8 HIS A 116
HIS A 252
HIS A 256
GLY A 271
 CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
 0.33A 5m8rC-4z11A:
17.3		 5m8rC-4z11A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.85A 5mhwA-4z11A:
undetectable		 5mhwA-4z11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.85A 5mhxA-4z11A:
undetectable		 5mhxA-4z11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.85A 5mhyA-4z11A:
undetectable		 5mhyA-4z11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.85A 5mhzA-4z11A:
undetectable		 5mhzA-4z11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.84A 5mi1A-4z11A:
undetectable		 5mi1A-4z11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.84A 5mi2A-4z11A:
undetectable		 5mi2A-4z11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.85A 5miaA-4z11A:
undetectable		 5miaA-4z11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.84A 5mibA-4z11A:
undetectable		 5mibA-4z11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.84A 5micA-4z11A:
undetectable		 5micA-4z11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.85A 5midA-4z11A:
undetectable		 5midA-4z11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.85A 5mieA-4z11A:
undetectable		 5mieA-4z11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		3 / 3 HIS A 116
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.17A 5migA-4z11A:
undetectable		 5migA-4z11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 PHE A  86
ILE A  72
ALA A  57
SER A 161
VAL A 281
 None
 1.39A 5mlmA-4z11A:
undetectable		 5mlmA-4z11A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 ILE A 115
HIS A 252
HIS A 256
HIS A 286
 None
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
 1.02A 5n5kA-4z11A:
undetectable		 5n5kA-4z11A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 CYH A  97
ILE A 115
HIS A 286
HIS A 252
 CU  A 700 (-3.5A)
None
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
 1.28A 5ocsA-4z11A:
undetectable		 5ocsA-4z11A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 6 ARG A 396
THR A 481
ASP A 480
LEU A 477
 None
 1.17A 5tdzA-4z11A:
undetectable		 5tdzA-4z11A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		3 / 3 LEU A 172
VAL A  65
ASP A  66
 None
 0.47A 5x23A-4z11A:
undetectable		 5x23A-4z11A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		3 / 3 ASP A 190
PHE A 431
ARG A 496
 None
 1.13A 5yw0A-4z11A:
undetectable		 5yw0A-4z11A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		3 / 3 HIS A 252
HIS A 256
HIS A 286
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
 0.23A 5zrdA-4z11A:
19.6		 5zrdA-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A  93
HIS A 116
PHE A 121
HIS A 125
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
CU  A 700 (-3.2A)
 1.06A 5zrdB-4z11A:
19.7		 5zrdB-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A 125
HIS A  93
PHE A 273
HIS A 116
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
CU  A 700 (-3.2A)
 1.03A 5zrdB-4z11A:
19.7		 5zrdB-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 5 HIS A 252
HIS A 256
PHE A 282
HIS A 285
HIS A 286
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
None
CU  A 701 (-3.1A)
 0.29A 5zrdB-4z11A:
19.7		 5zrdB-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A  93
CYH A  97
HIS A 116
PHE A 282
 CU  A 700 (-3.2A)
CU  A 700 (-3.5A)
CU  A 700 (-3.2A)
None
 1.12A 5zrdB-4z11A:
19.7		 5zrdB-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A  93
HIS A 116
HIS A 125
PHE A 282
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 0.29A 5zrdB-4z11A:
19.7		 5zrdB-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A 252
HIS A 256
HIS A 286
PHE A 121
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
 0.97A 5zrdB-4z11A:
19.7		 5zrdB-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 252
HIS A 256
HIS A 285
HIS A 286
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
CU  A 701 (-3.1A)
 0.24A 5zrdC-4z11A:
18.7		 5zrdC-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A  93
CYH A  97
HIS A 116
PHE A 282
 CU  A 700 (-3.2A)
CU  A 700 (-3.5A)
CU  A 700 (-3.2A)
None
 1.13A 5zrdC-4z11A:
18.7		 5zrdC-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A  93
HIS A 116
HIS A 125
PHE A 282
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 0.27A 5zrdC-4z11A:
18.7		 5zrdC-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A 252
HIS A 256
HIS A 286
PHE A 121
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
 1.00A 5zrdC-4z11A:
18.7		 5zrdC-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A  93
CYH A  97
HIS A 116
PHE A 282
 CU  A 700 (-3.2A)
CU  A 700 (-3.5A)
CU  A 700 (-3.2A)
None
 1.11A 5zrdD-4z11A:
4.4		 5zrdD-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A  93
HIS A 116
HIS A 125
PHE A 282
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 0.30A 5zrdD-4z11A:
4.4		 5zrdD-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 5 HIS A 252
HIS A 256
HIS A 286
PHE A 121
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
 0.97A 5zrdD-4z11A:
4.4		 5zrdD-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 HIS A 252
HIS A 256
HIS A 285
HIS A 286
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
CU  A 701 (-3.1A)
 0.22A 5zrdD-4z11A:
4.4		 5zrdD-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 4 GLY A 166
ARG A  69
ASN A 170
LEU A 165
 None
 1.47A 6b58A-4z11A:
undetectable		 6b58A-4z11A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 6 PHE A 164
ARG A 177
ILE A  72
ASP A 279
 None
 1.40A 6dhbA-4z11A:
undetectable		 6dhbA-4z11A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 ILE A 418
PHE A 428
GLY A 452
ILE A 507
LEU A 493
 None
 1.02A 6dwnC-4z11A:
undetectable		 6dwnC-4z11A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		5 / 12 ILE A 418
PHE A 428
GLY A 452
ILE A 507
LEU A 493
 None
 1.10A 6dwnD-4z11A:
undetectable		 6dwnD-4z11A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 8 ASP A 197
ILE A 198
ASN A 207
TYR A 191
 None
 0.97A 6hisA-4z11A:
undetectable
6hisB-4z11A:
undetectable		 6hisA-4z11A:
11.68
6hisB-4z11A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 8 ASP A 197
ILE A 198
ASN A 207
TYR A 191
 None
 0.97A 6hisB-4z11A:
undetectable
6hisC-4z11A:
undetectable		 6hisB-4z11A:
11.68
6hisC-4z11A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 8 ASP A 197
ILE A 198
ASN A 207
TYR A 191
 None
 0.95A 6hisC-4z11A:
undetectable
6hisD-4z11A:
undetectable		 6hisC-4z11A:
11.68
6hisD-4z11A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 8 ASP A 197
ILE A 198
ASN A 207
TYR A 191
 None
 0.97A 6hisD-4z11A:
undetectable
6hisE-4z11A:
undetectable		 6hisD-4z11A:
11.68
6hisE-4z11A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4z11 AURONE SYNTHASE
(Coreopsis
grandiflora) 		4 / 8 ASN A 207
TYR A 191
ASP A 197
ILE A 198
 None
 0.94A 6hisA-4z11A:
undetectable
6hisE-4z11A:
undetectable		 6hisA-4z11A:
11.68
6hisE-4z11A:
11.68