SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z17'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		5 / 10 TYR A 418
PHE A 176
PRO A 144
VAL A 145
ILE A 238
 None
 1.49A 13gsA-4z17A:
undetectable		 13gsA-4z17A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK5_A_T44A1008_1
(SERUM ALBUMIN)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		5 / 10 LYS A 121
ALA A 119
GLU A  23
VAL A  72
VAL A  26
 None
 1.48A 1hk5A-4z17A:
2.2		 1hk5A-4z17A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		3 / 3 GLU A  12
LYS A  67
VAL A  65
 None
 0.94A 1l2iA-4z17A:
undetectable		 1l2iA-4z17A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		5 / 11 SER A 344
THR A 346
THR A 383
ILE A 337
VAL A 364
 None
 1.16A 1pkvA-4z17A:
undetectable
1pkvB-4z17A:
undetectable		 1pkvA-4z17A:
12.77
1pkvB-4z17A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		5 / 11 ILE A 337
VAL A 364
SER A 344
THR A 346
THR A 383
 None
 1.15A 1pkvA-4z17A:
undetectable
1pkvB-4z17A:
undetectable		 1pkvA-4z17A:
12.77
1pkvB-4z17A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		5 / 12 ILE A 168
ALA A 394
GLY A 208
LEU A 222
LEU A 190
 None
 0.98A 1rjdC-4z17A:
undetectable		 1rjdC-4z17A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		5 / 10 ASP A  92
LEU A  95
ILE A   5
TYR A 134
THR A 346
 None
 1.32A 1tdrB-4z17A:
undetectable		 1tdrB-4z17A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		3 / 3 ASP A 397
ARG A 395
ASP A  15
 None
 0.89A 1vptA-4z17A:
undetectable		 1vptA-4z17A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		4 / 8 VAL A  72
LEU A  28
GLY A  34
ALA A 122
 None
 0.90A 2xfsA-4z17A:
undetectable		 2xfsA-4z17A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		4 / 8 VAL A  72
LEU A  28
GLY A  34
ALA A 122
 None
 0.93A 2xh9A-4z17A:
undetectable		 2xh9A-4z17A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		5 / 11 SER A 368
GLN A 341
ASP A 313
ASN A 149
ASP A 243
 PEP  A 502 (-4.0A)
None
MG  A 501 (-3.3A)
None
MG  A 501 ( 2.5A)
 1.44A 4fevE-4z17A:
undetectable		 4fevE-4z17A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		5 / 12 PHE A 424
ALA A 241
VAL A 311
LEU A 336
GLN A 309
 None
 1.08A 4jbtA-4z17A:
undetectable		 4jbtA-4z17A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		5 / 12 PHE A 199
PRO A 211
GLY A 208
ILE A 150
LEU A 222
 None
 1.40A 4kotA-4z17A:
undetectable		 4kotA-4z17A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		4 / 5 LEU A 143
SER A 175
LEU A 406
LEU A 412
 None
 1.22A 4n09B-4z17A:
undetectable		 4n09B-4z17A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		4 / 5 LEU A 143
SER A 175
LEU A 406
LEU A 412
 None
 1.22A 4n09D-4z17A:
undetectable		 4n09D-4z17A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		4 / 5 LEU A  95
ALA A 109
VAL A  24
ILE A  22
 None
 0.98A 4xe3A-4z17A:
undetectable		 4xe3A-4z17A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		4 / 7 TYR A 132
ALA A 124
GLU A 411
GLY A 128
 None
 0.84A 5e26A-4z17A:
undetectable
5e26B-4z17A:
undetectable		 5e26A-4z17A:
21.06
5e26B-4z17A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		4 / 7 GLU A 411
GLY A 128
TYR A 132
ALA A 124
 None
 0.82A 5e26C-4z17A:
undetectable
5e26D-4z17A:
undetectable		 5e26C-4z17A:
21.06
5e26D-4z17A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		5 / 12 SER A 116
LEU A 113
GLY A 114
VAL A  24
LEU A 339
 None
 1.46A 5jo9A-4z17A:
undetectable		 5jo9A-4z17A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		4 / 4 LEU A 299
GLY A 296
SER A 266
SER A 265
 None
 0.93A 5uunA-4z17A:
undetectable		 5uunA-4z17A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		4 / 4 LEU A 299
GLY A 296
SER A 266
SER A 265
 None
 0.86A 5uunB-4z17A:
undetectable		 5uunB-4z17A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4z17 ENOLASE
(Chloroflexus
aurantiacus) 		3 / 3 LEU A 304
VAL A 270
ASP A 271
 None
 0.65A 5x23A-4z17A:
undetectable		 5x23A-4z17A:
19.54