SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z19'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 11 THR A 253
LEU A 219
GLY A 310
THR A 116
VAL A 279
 None
 1.29A 1akdA-4z19A:
undetectable		 1akdA-4z19A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		4 / 8 THR A 253
LEU A 219
THR A 116
VAL A 279
 None
 1.13A 1o76B-4z19A:
undetectable		 1o76B-4z19A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 ILE A 174
VAL A 279
VAL A 265
ILE A 292
ILE A   5
 None
 1.33A 1r5lA-4z19A:
undetectable		 1r5lA-4z19A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 VAL A  78
ASP A 107
SER A  84
GLY A 158
ILE A  44
 None
 1.36A 1xvaA-4z19A:
undetectable		 1xvaA-4z19A:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 LEU A 247
ASN A 246
GLN A 244
ALA A 252
PHE A 212
 None
 1.03A 2oz7A-4z19A:
undetectable		 2oz7A-4z19A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		4 / 7 ALA A 254
THR A 253
ALA A 252
PRO A 242
 None
 0.75A 2ql8A-4z19A:
undetectable
2ql8B-4z19A:
undetectable		 2ql8A-4z19A:
18.15
2ql8B-4z19A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		4 / 7 PHE A 303
GLY A 305
ASP A 182
ARG A 184
 None
SCY  A 112 ( 3.9A)
None
None
 0.95A 3aruA-4z19A:
undetectable		 3aruA-4z19A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 11 GLY A 152
THR A  37
ILE A  33
LEU A  22
THR A  28
 None
 1.03A 3bf1A-4z19A:
undetectable
3bf1B-4z19A:
undetectable		 3bf1A-4z19A:
24.04
3bf1B-4z19A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 LEU A  22
THR A  28
GLY A 152
THR A  37
ILE A  33
 None
 1.04A 3bf1A-4z19A:
undetectable
3bf1B-4z19A:
undetectable		 3bf1A-4z19A:
24.04
3bf1B-4z19A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 11 LEU A  22
THR A  28
GLY A 152
THR A  37
ILE A  33
 None
 1.06A 3bf1C-4z19A:
undetectable
3bf1D-4z19A:
undetectable		 3bf1C-4z19A:
24.04
3bf1D-4z19A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 11 LEU A  22
THR A  28
GLY A 152
THR A  37
ILE A  33
 None
 1.03A 3bf1E-4z19A:
undetectable
3bf1F-4z19A:
undetectable		 3bf1E-4z19A:
24.04
3bf1F-4z19A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 ALA A  91
ILE A 135
LEU A   6
LEU A  75
GLY A  74
 None
 1.17A 3k2hA-4z19A:
undetectable		 3k2hA-4z19A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 LEU A  98
ALA A 122
VAL A 164
GLY A   7
ALA A  62
 None
 1.00A 3ln1A-4z19A:
undetectable		 3ln1A-4z19A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 LEU A  98
ALA A 122
VAL A 164
GLY A   7
ALA A  62
 None
 1.01A 3ln1B-4z19A:
0.3		 3ln1B-4z19A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 LEU A  98
ALA A 122
VAL A 164
GLY A   7
ALA A  62
 None
 1.00A 3ln1C-4z19A:
undetectable		 3ln1C-4z19A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 LEU A  98
ALA A 122
VAL A 164
GLY A   7
ALA A  62
 None
 1.00A 3ln1D-4z19A:
undetectable		 3ln1D-4z19A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 GLY A 306
GLY A 183
ALA A 110
ALA A 111
LEU A 188
 None
None
None
SCY  A 112 ( 2.7A)
None
 1.06A 3p2kC-4z19A:
undetectable		 3p2kC-4z19A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 GLY A 306
GLY A 183
ALA A 110
ALA A 111
LEU A 188
 None
None
None
SCY  A 112 ( 2.7A)
None
 1.04A 3p2kD-4z19A:
undetectable		 3p2kD-4z19A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 10 ALA A 254
LEU A 299
LEU A 219
ALA A 302
THR A 116
 None
None
None
SCY  A 112 ( 3.7A)
None
 1.15A 3r9cA-4z19A:
undetectable		 3r9cA-4z19A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		4 / 5 SER A 139
SER A  83
VAL A  51
GLY A  55
 None
 1.06A 3rxhA-4z19A:
undetectable		 3rxhA-4z19A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 GLY A   9
ASP A 284
PHE A 283
GLU A  60
ALA A  62
 None
 1.22A 3t7sA-4z19A:
undetectable		 3t7sA-4z19A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 GLY A   9
ASP A 284
PHE A 283
GLU A  60
ALA A  62
 None
 1.24A 3t7sB-4z19A:
undetectable		 3t7sB-4z19A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 LEU A  22
THR A  28
GLY A 152
THR A  37
ILE A  33
 None
 1.06A 4o5fA-4z19A:
undetectable
4o5fB-4z19A:
undetectable		 4o5fA-4z19A:
24.25
4o5fB-4z19A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 GLY A 138
ALA A 277
SER A 275
ILE A  76
SER A 105
 None
None
SCY  A 112 ( 3.5A)
None
None
 1.22A 4rtpA-4z19A:
undetectable		 4rtpA-4z19A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 GLY A 152
THR A  37
ILE A  33
LEU A  22
THR A  28
 None
 1.09A 5b8hA-4z19A:
undetectable
5b8hB-4z19A:
undetectable		 5b8hA-4z19A:
24.16
5b8hB-4z19A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		4 / 8 SER A 278
ALA A 277
HIS A 243
LEU A 142
 None
None
SCY  A 112 ( 3.7A)
None
 0.97A 5dzkF-4z19A:
undetectable
5dzkT-4z19A:
undetectable		 5dzkF-4z19A:
22.57
5dzkT-4z19A:
1.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 LEU A  98
ALA A 122
VAL A 164
GLY A   7
ALA A  62
 None
 0.98A 5jw1A-4z19A:
undetectable		 5jw1A-4z19A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		5 / 12 LEU A  98
ALA A 122
VAL A 164
GLY A   7
ALA A  62
 None
 1.02A 5jw1B-4z19A:
undetectable		 5jw1B-4z19A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Yersinia
pestis) 		4 / 7 GLN A  93
VAL A  94
ALA A  59
TYR A  11
 None
 0.94A 6cduH-4z19A:
undetectable
6cduI-4z19A:
undetectable		 6cduH-4z19A:
23.66
6cduI-4z19A:
23.66