SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z1a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Helicobacter
pylori) 		5 / 10 ASP A 201
ASN A 128
ILE A 103
GLU A 241
GLY A  16
 None
 1.29A 1mehA-4z1aA:
11.0		 1mehA-4z1aA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Helicobacter
pylori) 		4 / 5 TYR A 142
LYS A 146
ILE A 117
MET A 192
 None
 1.19A 1opjA-4z1aA:
undetectable		 1opjA-4z1aA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Helicobacter
pylori) 		4 / 6 ILE A 117
SER A 121
ARG A 151
ILE A 155
 None
 1.11A 2q72A-4z1aA:
undetectable		 2q72A-4z1aA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Helicobacter
pylori) 		5 / 12 ASP A 236
ILE A 235
ASP A 185
ARG A 187
LEU A 189
 None
 1.09A 3iv6D-4z1aA:
undetectable		 3iv6D-4z1aA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Helicobacter
pylori) 		5 / 10 ALA A  30
GLY A  16
LEU A  73
LEU A  26
ILE A  20
 None
 0.96A 3wdmB-4z1aA:
undetectable		 3wdmB-4z1aA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Helicobacter
pylori) 		5 / 9 ALA A  30
GLY A  16
LEU A  73
LEU A  26
ILE A  20
 None
 1.00A 3wdmC-4z1aA:
undetectable		 3wdmC-4z1aA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Helicobacter
pylori) 		5 / 10 ALA A  30
GLY A  16
LEU A  73
LEU A  26
ILE A  20
 None
 1.09A 3wdmD-4z1aA:
undetectable		 3wdmD-4z1aA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Helicobacter
pylori) 		4 / 8 VAL A 120
VAL A 127
ILE A 129
LEU A 110
 None
 0.89A 4jq1B-4z1aA:
6.9		 4jq1B-4z1aA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Helicobacter
pylori) 		4 / 6 LEU A 238
GLU A 172
VAL A 233
ALA A 232
 None
 1.01A 4nkxA-4z1aA:
undetectable		 4nkxA-4z1aA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Helicobacter
pylori) 		5 / 12 VAL A 233
ALA A 229
THR A 203
GLY A 237
LEU A 238
 None
 1.14A 5m54E-4z1aA:
undetectable		 5m54E-4z1aA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Helicobacter
pylori) 		5 / 12 VAL A 233
ALA A 229
THR A 203
GLY A 237
LEU A 238
 None
 1.11A 5m5cB-4z1aA:
2.1		 5m5cB-4z1aA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Helicobacter
pylori) 		5 / 10 VAL A 233
ALA A 229
THR A 203
GLY A 237
LEU A 238
 None
 1.08A 5m5cE-4z1aA:
undetectable		 5m5cE-4z1aA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Helicobacter
pylori) 		5 / 9 GLU A 261
LEU A 257
MET A 256
GLY A  16
LEU A  33
 None
 1.45A 5wgqA-4z1aA:
undetectable		 5wgqA-4z1aA:
15.94