SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		4 / 8 ASP A 294
ASP A 235
TYR A 232
THR A 263
 None
 1.24A 1ceaA-4z1pA:
undetectable
1ceaB-4z1pA:
undetectable		 1ceaA-4z1pA:
11.66
1ceaB-4z1pA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		4 / 6 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.17A 1dz4B-4z1pA:
undetectable		 1dz4B-4z1pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		3 / 3 ALA A 210
VAL A 208
TRP A 206
 None
 0.68A 1kqeA-4z1pA:
undetectable
1kqeE-4z1pA:
undetectable		 1kqeA-4z1pA:
3.74
1kqeE-4z1pA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		3 / 3 ALA A 210
VAL A 208
TRP A 206
 None
 0.71A 1kqeB-4z1pA:
undetectable
1kqeD-4z1pA:
undetectable		 1kqeB-4z1pA:
3.74
1kqeD-4z1pA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		3 / 3 TRP A 206
ALA A 210
VAL A 208
 None
 0.70A 1kqeB-4z1pA:
undetectable
1kqeD-4z1pA:
undetectable		 1kqeB-4z1pA:
3.74
1kqeD-4z1pA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		3 / 3 TRP A 206
ALA A 210
VAL A 208
 None
 0.73A 1kqeA-4z1pA:
undetectable
1kqeE-4z1pA:
undetectable		 1kqeA-4z1pA:
3.74
1kqeE-4z1pA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		3 / 3 ALA A 210
VAL A 208
TRP A 206
 None
 0.51A 1micA-4z1pA:
undetectable
1micB-4z1pA:
undetectable		 1micA-4z1pA:
4.98
1micB-4z1pA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		4 / 5 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.18A 1t88B-4z1pA:
undetectable		 1t88B-4z1pA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		4 / 5 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.20A 2m56A-4z1pA:
undetectable		 2m56A-4z1pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		5 / 9 ILE A  98
ILE A 155
PHE A 109
THR A 113
LEU A  90
 None
 1.10A 2m9qA-4z1pA:
undetectable		 2m9qA-4z1pA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		5 / 9 LEU A  94
ILE A 155
PHE A 109
THR A 113
LEU A  90
 None
 1.15A 2m9qA-4z1pA:
undetectable		 2m9qA-4z1pA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		4 / 6 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.18A 2zawA-4z1pA:
undetectable		 2zawA-4z1pA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		5 / 12 GLN A 283
TYR A 260
ASP A 279
ASP A 247
ILE A 251
 None
 1.45A 3b7pB-4z1pA:
undetectable		 3b7pB-4z1pA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_A_TESA339_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		5 / 10 TYR A 265
THR A 326
ASN A 308
VAL A 179
VAL A 199
 None
 0.97A 3burA-4z1pA:
undetectable		 3burA-4z1pA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAS_B_ASDB331_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		5 / 9 TYR A 265
THR A 326
ASN A 308
VAL A 179
VAL A 199
 None
 0.94A 3casB-4z1pA:
0.0		 3casB-4z1pA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		5 / 11 LEU A  59
ALA A  58
LEU A 170
ASN A 168
ALA A  22
 None
 1.17A 3e22B-4z1pA:
undetectable		 3e22B-4z1pA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		5 / 11 LEU A  59
ALA A  58
LEU A 170
ASN A 168
ALA A  22
 None
 1.20A 3e22D-4z1pA:
undetectable		 3e22D-4z1pA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		5 / 12 TYR A 219
ILE A 243
GLY A 205
LEU A 274
LEU A 281
 None
 1.04A 3em0B-4z1pA:
undetectable		 3em0B-4z1pA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		4 / 6 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.13A 3fwgA-4z1pA:
undetectable		 3fwgA-4z1pA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		4 / 6 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.13A 3wrhE-4z1pA:
undetectable		 3wrhE-4z1pA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		4 / 6 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.12A 3wrjE-4z1pA:
undetectable		 3wrjE-4z1pA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		4 / 8 LYS A 202
LEU A 180
GLU A 204
VAL A 238
 None
 0.86A 4ik6B-4z1pA:
undetectable		 4ik6B-4z1pA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		4 / 6 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.16A 4kkyX-4z1pA:
undetectable		 4kkyX-4z1pA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		4 / 5 TYR A 133
LEU A  79
VAL A  75
VAL A 125
 None
 1.16A 4l49A-4z1pA:
undetectable		 4l49A-4z1pA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		3 / 3 ASP A  74
LYS A  65
LEU A 135
 None
 1.06A 4ptjA-4z1pA:
undetectable		 4ptjA-4z1pA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		5 / 12 LEU A  59
ALA A  58
LEU A 170
ASN A 168
ALA A  22
 None
 1.21A 4x1iB-4z1pA:
undetectable		 4x1iB-4z1pA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		5 / 12 LEU A  59
ALA A  58
LEU A 170
ASN A 168
ALA A  22
 None
 1.10A 4x1yB-4z1pA:
undetectable		 4x1yB-4z1pA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		5 / 11 LEU A  90
LEU A  97
ALA A  50
VAL A  52
ILE A 155
 None
 1.08A 4x20D-4z1pA:
undetectable		 4x20D-4z1pA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 4z1p CELL WALL SURFACE
ANCHOR PROTEIN
(Streptococcus
agalactiae) 		4 / 8 GLY A 291
ALA A 292
ASP A 293
GLY A 254
 None
 0.67A 5kr1B-4z1pA:
undetectable		 5kr1B-4z1pA:
13.73