SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z1x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 4z1x LAGLIDADG
ENDONUCLEASE
(Fusarium
graminearum) 		3 / 3 MET A 170
MET A 162
PHE A 231
 None
 1.29A 3gn8A-4z1xA:
undetectable		 3gn8A-4z1xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 4z1x LAGLIDADG
ENDONUCLEASE
(Fusarium
graminearum) 		4 / 7 SER A 181
THR A 184
THR A 185
TYR A 281
 None
 1.08A 3tneB-4z1xA:
undetectable		 3tneB-4z1xA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4z1x LAGLIDADG
ENDONUCLEASE
(Fusarium
graminearum) 		5 / 12 GLY A 172
GLY A  14
THR A  13
PHE A 210
ILE A 164
 None
 1.17A 4zvmA-4z1xA:
undetectable
4zvmB-4z1xA:
undetectable		 4zvmA-4z1xA:
20.00
4zvmB-4z1xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4z1x LAGLIDADG
ENDONUCLEASE
(Fusarium
graminearum) 		4 / 6 PHE A 219
PHE A 173
THR A  95
TRP A 169
 None
 1.30A 5g08A-4z1xA:
undetectable		 5g08A-4z1xA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_ACTA504_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4z1x LAGLIDADG
ENDONUCLEASE
(Fusarium
graminearum) 		4 / 4 VAL A  72
ASN A  65
LYS A  74
TYR A  73
 None
 0.77A 5yf0A-4z1xA:
0.0		 5yf0A-4z1xA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_B_ACTB502_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4z1x LAGLIDADG
ENDONUCLEASE
(Fusarium
graminearum) 		4 / 4 VAL A  72
ASN A  65
LYS A  74
TYR A  73
 None
 0.75A 5yf0B-4z1xA:
0.0		 5yf0B-4z1xA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 4z1x LAGLIDADG
ENDONUCLEASE
(Fusarium
graminearum) 		4 / 8 TYR A  73
PHE A  39
PHE A  88
HIS A  87
 None
 1.21A 6huoC-4z1xA:
undetectable
6huoD-4z1xA:
undetectable		 6huoC-4z1xA:
13.94
6huoD-4z1xA:
14.94