SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z26'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.79A 1hxbB-4z26A:
undetectable		 1hxbB-4z26A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		4 / 8 SER A 584
SER A 582
GLN A 308
THR A 303
 None
 0.91A 1ig3A-4z26A:
undetectable
1ig3B-4z26A:
undetectable		 1ig3A-4z26A:
17.30
1ig3B-4z26A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 11 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.66A 1t3rB-4z26A:
undetectable		 1t3rB-4z26A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A 267
ILE A 266
ALA A 273
LEU A  36
ILE A  34
 None
 1.16A 1xzxX-4z26A:
undetectable		 1xzxX-4z26A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.90A 2f80A-4z26A:
undetectable		 2f80A-4z26A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.81A 2f80B-4z26A:
undetectable		 2f80B-4z26A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 9 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.94A 2o4pB-4z26A:
undetectable		 2o4pB-4z26A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.86A 2qakB-4z26A:
undetectable		 2qakB-4z26A:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 10 THR A 598
VAL A 295
VAL A 589
ASP A 590
VAL A 595
 None
 1.35A 2qboA-4z26A:
undetectable		 2qboA-4z26A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 SER A 342
TYR A 341
HIS A 340
 None
 0.77A 2r2vD-4z26A:
undetectable		 2r2vD-4z26A:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.99A 2r5pA-4z26A:
undetectable		 2r5pA-4z26A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 1.00A 2r5pC-4z26A:
undetectable		 2r5pC-4z26A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 VAL A  10
THR A 598
PHE A 268
ILE A 266
SER A 310
 None
 1.40A 2vdyB-4z26A:
undetectable		 2vdyB-4z26A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 ARG A 507
GLY A 510
SER A 361
 None
 0.65A 2xctB-4z26A:
undetectable		 2xctB-4z26A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		4 / 6 VAL A 603
LEU A 307
CYH A 583
SER A 607
 None
 1.19A 3b6rB-4z26A:
undetectable		 3b6rB-4z26A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAS_A_ASDA332_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 10 TRP A 121
THR A 303
VAL A 296
VAL A 603
LEU A 593
 None
 1.50A 3casA-4z26A:
undetectable		 3casA-4z26A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.77A 3cywA-4z26A:
undetectable		 3cywA-4z26A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.85A 3cywB-4z26A:
undetectable		 3cywB-4z26A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.92A 3d20B-4z26A:
undetectable		 3d20B-4z26A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A 162
LEU A 160
LEU A 177
PRO A 193
VAL A 188
 None
 1.25A 3dcjA-4z26A:
2.2
3dcjB-4z26A:
2.6		 3dcjA-4z26A:
16.85
3dcjB-4z26A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 SER A 298
THR A 297
GLY A  97
GLY A  15
ILE A 104
 FAD  A 901 (-3.7A)
None
FAD  A 901 (-4.8A)
FAD  A 901 (-3.2A)
None
 1.26A 3fzgA-4z26A:
undetectable		 3fzgA-4z26A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.87A 3jvyA-4z26A:
undetectable		 3jvyA-4z26A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.86A 3jvyB-4z26A:
undetectable		 3jvyB-4z26A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.90A 3k4vC-4z26A:
undetectable		 3k4vC-4z26A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		4 / 5 ASP A 576
ASP A 432
TYR A 399
PRO A 343
 None
 1.40A 3l2wA-4z26A:
undetectable		 3l2wA-4z26A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.79A 3lzsA-4z26A:
undetectable		 3lzsA-4z26A:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.88A 3lzsB-4z26A:
undetectable		 3lzsB-4z26A:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.84A 3lzuA-4z26A:
undetectable		 3lzuA-4z26A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.86A 3mwsB-4z26A:
undetectable		 3mwsB-4z26A:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.93A 3ndtD-4z26A:
undetectable		 3ndtD-4z26A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.90A 3nduC-4z26A:
undetectable		 3nduC-4z26A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		6 / 12 LEU A  25
TYR A  24
GLY A 625
TRP A 618
LEU A  35
ALA A 232
 None
 1.50A 3ou6A-4z26A:
2.2		 3ou6A-4z26A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		6 / 12 LEU A  25
GLY A 625
TRP A 618
LEU A  35
ALA A 232
HIS A  23
 None
 1.34A 3ou6B-4z26A:
2.3		 3ou6B-4z26A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		6 / 12 LEU A  25
TYR A  24
GLY A 625
TRP A 618
LEU A  35
ALA A 232
 None
 1.49A 3ou6B-4z26A:
2.3		 3ou6B-4z26A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 GLY A 100
GLY A 233
LEU A 237
ALA A  38
HIS A  40
 FAD  A 901 (-3.3A)
None
None
FAD  A 901 (-3.6A)
None
 1.14A 3ou7B-4z26A:
undetectable		 3ou7B-4z26A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  25
TRP A 618
LEU A  35
ALA A 232
HIS A  23
 None
 1.21A 3ou7C-4z26A:
2.3		 3ou7C-4z26A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  25
TYR A  24
TRP A 618
LEU A  35
ALA A 232
 None
 1.35A 3ou7C-4z26A:
2.3		 3ou7C-4z26A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 11 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.82A 3oy4A-4z26A:
undetectable		 3oy4A-4z26A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PPO_A_DCKA401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 9 GLN A  79
ASN A  82
THR A 460
ASN A 339
TYR A 341
 None
 1.22A 3ppoA-4z26A:
0.0		 3ppoA-4z26A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.76A 3pwmA-4z26A:
undetectable		 3pwmA-4z26A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.83A 3pwrB-4z26A:
undetectable		 3pwrB-4z26A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.89A 3tkwA-4z26A:
undetectable		 3tkwA-4z26A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ILE A  92
PHE A 301
GLN A  79
PHE A 458
 None
 1.24A 3tvxB-4z26A:
undetectable		 3tvxB-4z26A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 VAL A 295
LEU A  36
ILE A  33
LEU A 255
VAL A 242
 None
 1.16A 3w68A-4z26A:
undetectable		 3w68A-4z26A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
ILE A 632
ILE A  33
LEU A 255
VAL A 242
 None
 1.01A 3w68D-4z26A:
undetectable		 3w68D-4z26A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 11 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.72A 4dqeA-4z26A:
undetectable		 4dqeA-4z26A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 11 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.62A 4dqhA-4z26A:
undetectable		 4dqhA-4z26A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 11 GLY A  18
GLY A 625
ALA A  22
LEU A  21
HIS A  23
 None
 1.18A 4l8fB-4z26A:
undetectable		 4l8fB-4z26A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ARG A  27
ALA A 232
ILE A 632
LEU A 638
GLY A 634
 None
 1.20A 4l9qA-4z26A:
undetectable		 4l9qA-4z26A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 10 PRO A 612
ALA A 609
GLY A 440
SER A 607
GLY A 580
 None
 1.02A 4mmdA-4z26A:
undetectable		 4mmdA-4z26A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 LEU A 307
SER A 310
ILE A 266
VAL A 276
 None
 0.92A 4tvtA-4z26A:
undetectable		 4tvtA-4z26A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		4 / 6 SER A  19
ARG A 239
GLY A 246
GLU A 244
 None
 0.99A 5btaA-4z26A:
undetectable
5btaB-4z26A:
undetectable
5btaC-4z26A:
undetectable		 5btaA-4z26A:
21.17
5btaB-4z26A:
17.74
5btaC-4z26A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		4 / 6 SER A  19
ARG A 239
GLY A 246
GLU A 244
 None
 1.05A 5btcA-4z26A:
undetectable
5btcC-4z26A:
undetectable
5btcD-4z26A:
undetectable		 5btcA-4z26A:
21.17
5btcC-4z26A:
21.17
5btcD-4z26A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		4 / 6 SER A  19
ARG A 239
GLY A 246
GLU A 244
 None
 1.04A 5btcA-4z26A:
1.6
5btcB-4z26A:
undetectable
5btcC-4z26A:
undetectable		 5btcA-4z26A:
21.17
5btcB-4z26A:
17.74
5btcC-4z26A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		4 / 6 ALA A  14
ARG A 239
GLY A 246
GLU A 244
 None
 0.94A 5btgA-4z26A:
undetectable
5btgB-4z26A:
undetectable
5btgC-4z26A:
undetectable		 5btgA-4z26A:
21.09
5btgB-4z26A:
17.74
5btgC-4z26A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		4 / 4 ASP A 523
HIS A 350
SER A 514
GLU A 516
 None
 1.46A 5hfjG-4z26A:
undetectable		 5hfjG-4z26A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.76A 5kqyA-4z26A:
undetectable		 5kqyA-4z26A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 HIS A 340
ASN A 616
ALA A 619
 None
FAD  A 901 (-3.9A)
None
 0.79A 5n4tB-4z26A:
undetectable		 5n4tB-4z26A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 GLY A 205
THR A 395
VAL A 394
ASN A 187
LEU A 198
 None
 1.22A 5nz0A-4z26A:
undetectable		 5nz0A-4z26A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  21
LEU A  20
ILE A   9
LEU A 633
LEU A 255
 None
 0.92A 5toaA-4z26A:
undetectable		 5toaA-4z26A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 10 ILE A  33
MET A 285
ILE A 306
LEU A  36
ALA A 261
 None
 1.33A 5zjiB-4z26A:
undetectable		 5zjiB-4z26A:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 GLY A 531
TRP A 539
TRP A 540
TYR A 535
 None
 1.16A 6ag0A-4z26A:
undetectable		 6ag0A-4z26A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 ILE A 456
ASN A 339
CYH A 581
 None
 0.92A 6bp4A-4z26A:
undetectable		 6bp4A-4z26A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A  36
VAL A 296
ILE A 267
VAL A  10
ILE A  12
 None
 0.92A 6dgxB-4z26A:
undetectable		 6dgxB-4z26A:
10.04