SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z2a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4z2a FURIN
(Homo
sapiens) 		4 / 7 GLY A 427
LEU A 337
ALA A 338
TYR A 426
 None
 0.91A 1dmaA-4z2aA:
undetectable		 1dmaA-4z2aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4z2a FURIN
(Homo
sapiens) 		5 / 11 HIS A 364
ALA A 371
HIS A 194
SER A 253
ALA A 292
 PO4  A 605 (-3.7A)
None
PO4  A 605 (-4.3A)
None
None
 1.14A 1gtnM-4z2aA:
undetectable
1gtnN-4z2aA:
undetectable		 1gtnM-4z2aA:
9.03
1gtnN-4z2aA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 HIS A 364
ALA A 371
HIS A 194
SER A 253
ALA A 292
 PO4  A 605 (-3.7A)
None
PO4  A 605 (-4.3A)
None
None
 1.14A 1gtnO-4z2aA:
undetectable
1gtnP-4z2aA:
undetectable		 1gtnO-4z2aA:
9.03
1gtnP-4z2aA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 HIS A 364
ALA A 371
HIS A 194
SER A 253
ALA A 292
 PO4  A 605 (-3.7A)
None
PO4  A 605 (-4.3A)
None
None
 1.17A 1gtnU-4z2aA:
undetectable
1gtnV-4z2aA:
undetectable		 1gtnU-4z2aA:
9.03
1gtnV-4z2aA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 4z2a FURIN
(Homo
sapiens) 		5 / 11 SER A 293
SER A 318
TYR A 329
GLY A 296
VAL A 326
 None
None
EDO  A 607 ( 4.3A)
None
None
 1.44A 1i9jH-4z2aA:
2.2
1i9jL-4z2aA:
undetectable		 1i9jH-4z2aA:
15.88
1i9jL-4z2aA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4z2a FURIN
(Homo
sapiens) 		4 / 4 GLY A 283
LEU A 285
GLY A 281
ARG A 282
 None
 1.20A 1j7kA-4z2aA:
undetectable		 1j7kA-4z2aA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 4z2a FURIN
(Homo
sapiens) 		3 / 3 ALA A 204
VAL A 215
TRP A 138
 None
 0.89A 1jo3A-4z2aA:
undetectable		 1jo3A-4z2aA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 4z2a FURIN
(Homo
sapiens) 		3 / 3 ALA A 204
VAL A 215
TRP A 138
 None
 0.89A 1jo3B-4z2aA:
undetectable		 1jo3B-4z2aA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4z2a FURIN
(Homo
sapiens) 		3 / 3 PHE A 118
TYR A 110
PRO A 113
 None
 0.95A 1mcnA-4z2aA:
undetectable
1mcnB-4z2aA:
undetectable
1mcnP-4z2aA:
undetectable		 1mcnA-4z2aA:
19.65
1mcnB-4z2aA:
19.65
1mcnP-4z2aA:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 VAL A 175
ASP A 174
TYR A 167
ASN A 243
LEU A 242
 None
CA  A 602 (-3.4A)
None
None
None
 1.46A 1mrlA-4z2aA:
0.0
1mrlC-4z2aA:
0.0		 1mrlA-4z2aA:
16.41
1mrlC-4z2aA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4z2a FURIN
(Homo
sapiens) 		4 / 4 THR A 340
LEU A 429
VAL A 397
LEU A 396
 None
 0.95A 1mz9D-4z2aA:
undetectable		 1mz9D-4z2aA:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 4z2a FURIN
(Homo
sapiens) 		4 / 6 ASP A 306
GLY A 307
THR A 309
SER A 335
 None
 0.76A 1n4fA-4z2aA:
undetectable		 1n4fA-4z2aA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 4z2a FURIN
(Homo
sapiens) 		3 / 3 ALA A 204
VAL A 215
TRP A 138
 None
 0.83A 1nt6A-4z2aA:
undetectable		 1nt6A-4z2aA:
2.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 4z2a FURIN
(Homo
sapiens) 		3 / 3 ALA A 204
VAL A 215
TRP A 138
 None
 0.83A 1nt6B-4z2aA:
undetectable		 1nt6B-4z2aA:
2.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 GLY A 212
VAL A 213
GLY A 214
THR A 354
HIS A 364
 CA  A 601 (-4.4A)
None
None
None
PO4  A 605 (-3.7A)
 1.31A 1pwyE-4z2aA:
undetectable		 1pwyE-4z2aA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 LEU A 549
ALA A 532
ALA A 489
VAL A 467
LEU A 455
 None
 1.30A 1rlbE-4z2aA:
undetectable		 1rlbE-4z2aA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 HIS A 364
ALA A 371
HIS A 194
SER A 253
ALA A 292
 PO4  A 605 (-3.7A)
None
PO4  A 605 (-4.3A)
None
None
 1.13A 1utdT-4z2aA:
undetectable
1utdU-4z2aA:
undetectable		 1utdT-4z2aA:
9.03
1utdU-4z2aA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4z2a FURIN
(Homo
sapiens) 		4 / 5 SER A 370
SER A 342
THR A 367
ASN A 295
 None
None
None
EDO  A 607 ( 3.9A)
 1.33A 1yvpA-4z2aA:
4.0		 1yvpA-4z2aA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4z2a FURIN
(Homo
sapiens) 		4 / 7 GLY A 432
TYR A 142
ASP A 430
ASN A 133
 None
 0.83A 2g70A-4z2aA:
undetectable		 2g70A-4z2aA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4z2a FURIN
(Homo
sapiens) 		4 / 7 GLY A 432
TYR A 142
ASP A 430
ASN A 133
 None
 0.86A 2g70B-4z2aA:
undetectable		 2g70B-4z2aA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4z2a FURIN
(Homo
sapiens) 		4 / 6 GLY A 432
TYR A 142
ASP A 430
ASN A 133
 None
 0.84A 2g72A-4z2aA:
undetectable		 2g72A-4z2aA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4z2a FURIN
(Homo
sapiens) 		4 / 7 GLY A 432
TYR A 142
ASP A 430
ASN A 133
 None
 0.81A 2g72B-4z2aA:
undetectable		 2g72B-4z2aA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4z2a FURIN
(Homo
sapiens) 		5 / 7 SER A 370
SER A 342
SER A 368
THR A 367
ASN A 295
 None
None
PO4  A 605 ( 3.9A)
None
EDO  A 607 ( 3.9A)
 1.18A 2i91A-4z2aA:
3.3		 2i91A-4z2aA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4z2a FURIN
(Homo
sapiens) 		5 / 7 SER A 370
SER A 342
SER A 368
THR A 367
ASN A 295
 None
None
PO4  A 605 ( 3.9A)
None
EDO  A 607 ( 3.9A)
 1.18A 2i91B-4z2aA:
3.8		 2i91B-4z2aA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4z2a FURIN
(Homo
sapiens) 		5 / 12 LEU A 505
LEU A 516
ALA A 502
LEU A 493
LEU A 465
 None
 1.28A 2oaxD-4z2aA:
undetectable		 2oaxD-4z2aA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4z2a FURIN
(Homo
sapiens) 		3 / 3 PRO A 256
GLY A 265
TYR A 308
 None
 0.71A 2vouA-4z2aA:
undetectable		 2vouA-4z2aA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 4z2a FURIN
(Homo
sapiens) 		4 / 8 GLY A 144
HIS A 145
ILE A 221
ASN A 166
 None
 0.78A 2x0pA-4z2aA:
undetectable		 2x0pA-4z2aA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4z2a FURIN
(Homo
sapiens) 		4 / 7 ILE A 452
LEU A 568
ARG A 448
THR A 482
 None
 1.12A 2zxwN-4z2aA:
undetectable
2zxwW-4z2aA:
undetectable		 2zxwN-4z2aA:
19.93
2zxwW-4z2aA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 4z2a FURIN
(Homo
sapiens) 		5 / 12 ALA A 199
GLY A 195
LEU A 152
SER A 150
GLY A 222
 None
 1.09A 3g2oB-4z2aA:
undetectable		 3g2oB-4z2aA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4z2a FURIN
(Homo
sapiens) 		4 / 6 SER A 150
ARG A 276
GLY A 277
GLU A 272
 None
 1.14A 3k9fA-4z2aA:
undetectable
3k9fB-4z2aA:
undetectable
3k9fD-4z2aA:
undetectable		 3k9fA-4z2aA:
21.28
3k9fB-4z2aA:
21.28
3k9fD-4z2aA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 4z2a FURIN
(Homo
sapiens) 		4 / 5 GLY A 195
ASP A 154
ARG A 193
GLN A 358
 None
None
PO4  A 606 ( 2.5A)
None
 1.14A 3qx3A-4z2aA:
undetectable		 3qx3A-4z2aA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 4z2a FURIN
(Homo
sapiens) 		4 / 5 GLY A 195
ASP A 154
ARG A 197
GLN A 358
 None
None
PO4  A 606 ( 2.9A)
None
 1.36A 3qx3A-4z2aA:
undetectable		 3qx3A-4z2aA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 4z2a FURIN
(Homo
sapiens) 		5 / 12 ALA A 252
ASP A 153
ILE A 151
ILE A 317
ILE A 249
 None
 1.01A 3s56A-4z2aA:
undetectable		 3s56A-4z2aA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4z2a FURIN
(Homo
sapiens) 		5 / 12 THR A 367
SER A 293
SER A 370
LEU A 429
VAL A 397
 None
 1.27A 3u9fH-4z2aA:
undetectable
3u9fI-4z2aA:
undetectable		 3u9fH-4z2aA:
17.58
3u9fI-4z2aA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4z2a FURIN
(Homo
sapiens) 		5 / 9 THR A 367
SER A 293
SER A 370
LEU A 429
VAL A 397
 None
 1.30A 3u9fP-4z2aA:
undetectable		 3u9fP-4z2aA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4z2a FURIN
(Homo
sapiens) 		5 / 12 THR A 367
SER A 293
SER A 370
LEU A 429
VAL A 397
 None
 1.39A 3u9fP-4z2aA:
undetectable
3u9fS-4z2aA:
undetectable		 3u9fP-4z2aA:
17.58
3u9fS-4z2aA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 4z2a FURIN
(Homo
sapiens) 		4 / 5 SER A 318
GLU A 331
THR A 367
ASP A 258
 None
CA  A 604 (-2.2A)
None
CA  A 604 (-3.2A)
 1.47A 3zs3A-4z2aA:
undetectable		 3zs3A-4z2aA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 4z2a FURIN
(Homo
sapiens) 		3 / 3 PHE A 275
TYR A 571
TYR A 313
 None
 1.08A 4ffwA-4z2aA:
undetectable		 4ffwA-4z2aA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4z2a FURIN
(Homo
sapiens) 		3 / 3 ARG A 519
ASP A 259
ARG A 498
 None
 0.65A 4mx0A-4z2aA:
undetectable		 4mx0A-4z2aA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4z2a FURIN
(Homo
sapiens) 		5 / 12 ALA A 369
GLY A 200
ASP A 355
GLU A 157
ALA A 199
 None
 1.10A 4pclA-4z2aA:
undetectable		 4pclA-4z2aA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4z2a FURIN
(Homo
sapiens) 		5 / 12 ALA A 206
ALA A 139
LEU A 124
GLY A 214
GLN A 121
 None
 1.17A 4r38B-4z2aA:
undetectable		 4r38B-4z2aA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4z2a FURIN
(Homo
sapiens) 		5 / 12 ALA A 206
ALA A 139
LEU A 124
GLY A 214
GLN A 121
 None
 1.18A 4r38D-4z2aA:
undetectable		 4r38D-4z2aA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 HIS A 364
ALA A 371
HIS A 194
SER A 253
ALA A 292
 PO4  A 605 (-3.7A)
None
PO4  A 605 (-4.3A)
None
None
 1.14A 5eeuO-4z2aA:
undetectable
5eeuP-4z2aA:
undetectable		 5eeuO-4z2aA:
9.03
5eeuP-4z2aA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 HIS A 364
ALA A 371
HIS A 194
SER A 253
ALA A 292
 PO4  A 605 (-3.7A)
None
PO4  A 605 (-4.3A)
None
None
 1.14A 5eevO-4z2aA:
undetectable
5eevP-4z2aA:
undetectable		 5eevO-4z2aA:
9.03
5eevP-4z2aA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 HIS A 364
ALA A 371
HIS A 194
SER A 253
ALA A 292
 PO4  A 605 (-3.7A)
None
PO4  A 605 (-4.3A)
None
None
 1.14A 5eewO-4z2aA:
undetectable
5eewP-4z2aA:
undetectable		 5eewO-4z2aA:
9.03
5eewP-4z2aA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 HIS A 364
ALA A 371
HIS A 194
SER A 253
ALA A 292
 PO4  A 605 (-3.7A)
None
PO4  A 605 (-4.3A)
None
None
 1.14A 5eexO-4z2aA:
undetectable
5eexP-4z2aA:
undetectable		 5eexO-4z2aA:
9.03
5eexP-4z2aA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 HIS A 364
ALA A 371
HIS A 194
SER A 253
ALA A 292
 PO4  A 605 (-3.7A)
None
PO4  A 605 (-4.3A)
None
None
 1.14A 5eeyO-4z2aA:
undetectable
5eeyP-4z2aA:
undetectable		 5eeyO-4z2aA:
9.03
5eeyP-4z2aA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 HIS A 364
ALA A 371
HIS A 194
SER A 253
ALA A 292
 PO4  A 605 (-3.7A)
None
PO4  A 605 (-4.3A)
None
None
 1.14A 5eezO-4z2aA:
undetectable
5eezP-4z2aA:
undetectable		 5eezO-4z2aA:
9.03
5eezP-4z2aA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 HIS A 364
ALA A 371
HIS A 194
SER A 253
ALA A 292
 PO4  A 605 (-3.7A)
None
PO4  A 605 (-4.3A)
None
None
 1.14A 5ef0O-4z2aA:
undetectable
5ef0P-4z2aA:
undetectable		 5ef0O-4z2aA:
9.03
5ef0P-4z2aA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 HIS A 364
ALA A 371
HIS A 194
SER A 253
ALA A 292
 PO4  A 605 (-3.7A)
None
PO4  A 605 (-4.3A)
None
None
 1.14A 5ef1O-4z2aA:
undetectable
5ef1P-4z2aA:
undetectable		 5ef1O-4z2aA:
9.03
5ef1P-4z2aA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 HIS A 364
ALA A 371
HIS A 194
SER A 253
ALA A 292
 PO4  A 605 (-3.7A)
None
PO4  A 605 (-4.3A)
None
None
 1.14A 5ef2O-4z2aA:
undetectable
5ef2P-4z2aA:
undetectable		 5ef2O-4z2aA:
9.03
5ef2P-4z2aA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4z2a FURIN
(Homo
sapiens) 		5 / 10 HIS A 364
ALA A 371
HIS A 194
SER A 253
ALA A 292
 PO4  A 605 (-3.7A)
None
PO4  A 605 (-4.3A)
None
None
 1.14A 5ef3O-4z2aA:
undetectable
5ef3P-4z2aA:
undetectable		 5ef3O-4z2aA:
9.03
5ef3P-4z2aA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4z2a FURIN
(Homo
sapiens) 		4 / 8 THR A 562
LEU A 493
ILE A 551
LEU A 491
 None
 0.94A 5g48A-4z2aA:
undetectable		 5g48A-4z2aA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4z2a FURIN
(Homo
sapiens) 		3 / 3 TYR A 341
SER A 319
TRP A 122
 None
 1.08A 5n8jB-4z2aA:
undetectable		 5n8jB-4z2aA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4z2a FURIN
(Homo
sapiens) 		3 / 3 TYR A 341
SER A 319
TRP A 122
 None
 1.05A 5n8jA-4z2aA:
undetectable		 5n8jA-4z2aA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN4_A_SC2A1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4z2a FURIN
(Homo
sapiens) 		4 / 4 HIS A 486
GLY A 572
ARG A 391
THR A 573
 None
 1.23A 5nn4A-4z2aA:
undetectable		 5nn4A-4z2aA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4z2a FURIN
(Homo
sapiens) 		4 / 7 TYR A 313
GLN A 280
TRP A 390
TYR A 571
 None
 1.44A 5ov9B-4z2aA:
undetectable		 5ov9B-4z2aA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4z2a FURIN
(Homo
sapiens) 		4 / 5 ASP A 526
PRO A 256
GLU A 257
THR A 262
 None
 1.45A 5uxcA-4z2aA:
undetectable		 5uxcA-4z2aA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 4z2a FURIN
(Homo
sapiens) 		6 / 12 GLY A 265
PHE A 528
ILE A 503
THR A 535
GLU A 331
GLY A 307
 None
None
None
None
CA  A 604 (-2.2A)
None
 1.14A 5veuH-4z2aA:
undetectable		 5veuH-4z2aA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4z2a FURIN
(Homo
sapiens) 		3 / 3 GLN A 399
TRP A 441
VAL A 444
 None
 1.06A 6auuA-4z2aA:
undetectable		 6auuA-4z2aA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4z2a FURIN
(Homo
sapiens) 		4 / 7 ALA A 375
ASP A 168
ILE A 221
ILE A 156
 None
 0.97A 6fbnA-4z2aA:
undetectable		 6fbnA-4z2aA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4z2a FURIN
(Homo
sapiens) 		4 / 6 ASP A 264
TYR A 308
GLU A 236
GLU A 230
 None
 1.01A 6mn5A-4z2aA:
undetectable		 6mn5A-4z2aA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4z2a FURIN
(Homo
sapiens) 		4 / 6 ASP A 264
TYR A 308
GLU A 236
GLU A 230
 None
 0.98A 6mn5C-4z2aA:
undetectable		 6mn5C-4z2aA:
10.09