SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z2e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		4 / 6 LEU A 447
ASP A 450
ILE A 464
ARG A 460
 None
 0.89A 1mt1A-4z2eA:
undetectable
1mt1F-4z2eA:
undetectable		 1mt1A-4z2eA:
8.01
1mt1F-4z2eA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		4 / 6 ILE A 464
ARG A 460
LEU A 447
ASP A 450
 None
 0.88A 1mt1B-4z2eA:
undetectable
1mt1C-4z2eA:
undetectable		 1mt1B-4z2eA:
14.88
1mt1C-4z2eA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		4 / 6 LEU A 447
ASP A 450
ILE A 464
ARG A 460
 None
 0.87A 1mt1G-4z2eA:
undetectable
1mt1J-4z2eA:
undetectable		 1mt1G-4z2eA:
8.01
1mt1J-4z2eA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		4 / 7 ILE A 464
ARG A 460
LEU A 447
ASP A 450
 None
 0.87A 1mt1H-4z2eA:
undetectable
1mt1K-4z2eA:
undetectable		 1mt1H-4z2eA:
14.88
1mt1K-4z2eA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		4 / 7 LEU A 447
ASP A 450
ILE A 464
ARG A 460
 None
 0.88A 1n13I-4z2eA:
undetectable
1n13L-4z2eA:
undetectable		 1n13I-4z2eA:
8.01
1n13L-4z2eA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		3 / 3 ILE A 227
ASP A 214
PHE A 215
 None
 0.59A 1uwjB-4z2eA:
2.6		 1uwjB-4z2eA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		4 / 7 ILE A 464
ARG A 460
LEU A 447
ASP A 450
 None
 0.88A 2qqcB-4z2eA:
undetectable
2qqcC-4z2eA:
undetectable		 2qqcB-4z2eA:
14.15
2qqcC-4z2eA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		4 / 7 LEU A 447
ASP A 450
ILE A 464
ARG A 460
 None
 0.86A 2qqcA-4z2eA:
undetectable
2qqcF-4z2eA:
undetectable		 2qqcA-4z2eA:
9.05
2qqcF-4z2eA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		4 / 7 ILE A 464
ARG A 460
LEU A 447
ASP A 450
 None
 0.87A 2qqcD-4z2eA:
undetectable
2qqcE-4z2eA:
undetectable		 2qqcD-4z2eA:
14.15
2qqcE-4z2eA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		4 / 7 LEU A 447
ASP A 450
ILE A 464
ARG A 460
 None
 0.85A 2qqcG-4z2eA:
undetectable
2qqcJ-4z2eA:
undetectable		 2qqcG-4z2eA:
9.05
2qqcJ-4z2eA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		4 / 7 LEU A 447
ASP A 450
ILE A 464
ARG A 460
 None
 0.87A 2qqcI-4z2eA:
undetectable
2qqcL-4z2eA:
undetectable		 2qqcI-4z2eA:
9.05
2qqcL-4z2eA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		4 / 7 LEU A 447
ASP A 450
ILE A 464
ARG A 460
 None
 0.96A 2qqdA-4z2eA:
undetectable
2qqdE-4z2eA:
undetectable		 2qqdA-4z2eA:
9.29
2qqdE-4z2eA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		4 / 8 ILE A 464
ARG A 460
LEU A 447
ASP A 450
 None
 0.89A 2qqdB-4z2eA:
undetectable
2qqdC-4z2eA:
undetectable		 2qqdB-4z2eA:
14.15
2qqdC-4z2eA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		5 / 9 PHE A 476
ARG A 134
ASP A 190
GLY A 186
ASN A 184
 None
 1.42A 4eb4C-4z2eA:
undetectable		 4eb4C-4z2eA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		3 / 3 ASP A 366
ARG A 362
ASP A 450
 None
 0.87A 4fzvA-4z2eA:
undetectable		 4fzvA-4z2eA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 4z2e DNA GYRASE SUBUNIT B
(Streptococcus
pneumoniae) 		4 / 7 GLY C 434
ASP C 435
GLY C 457
GLU C 475
 None
 0.72A 4koeA-4z2eC:
undetectable
4koeB-4z2eC:
undetectable
4koeD-4z2eC:
27.2		 4koeA-4z2eC:
19.15
4koeB-4z2eC:
19.15
4koeD-4z2eC:
57.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4z2e DNA GYRASE SUBUNIT B
(Streptococcus
pneumoniae) 		3 / 4 ARG C 456
GLY C 457
GLU C 475
 None
 0.20A 4z2dB-4z2eC:
undetectable
4z2dC-4z2eC:
35.1		 4z2dB-4z2eC:
19.26
4z2dC-4z2eC:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4z2e DNA GYRASE SUBUNIT B
(Streptococcus
pneumoniae) 		4 / 7 GLY C 434
ASP C 435
GLY C 457
GLU C 475
 None
 0.74A 4z53A-4z2eC:
25.6
4z53B-4z2eC:
25.3		 4z53A-4z2eC:
19.86
4z53B-4z2eC:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4z2e DNA GYRASE SUBUNIT A
(Streptococcus
pneumoniae) 		3 / 3 ASP A 366
ARG A 362
ASP A 450
 None
 0.87A 5zvgA-4z2eA:
undetectable		 5zvgA-4z2eA:
23.29