SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z2y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4z2y CALO6
(Micromonospora
echinospora) 		5 / 12 ASP A 181
GLY A 183
ASP A 206
ASP A 233
ASP A 253
 None
 1.06A 4pghB-4z2yA:
22.2		 4pghB-4z2yA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4z2y CALO6
(Micromonospora
echinospora) 		5 / 12 ALA A 188
GLY A 183
GLY A 185
PHE A 234
ASP A 253
 None
 1.00A 6clxA-4z2yA:
25.0		 6clxA-4z2yA:
39.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4z2y CALO6
(Micromonospora
echinospora) 		5 / 10 ALA A 188
GLY A 184
ASP A 206
PHE A 234
ASP A 253
 None
 1.10A 6clxB-4z2yA:
24.7		 6clxB-4z2yA:
39.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4z2y CALO6
(Micromonospora
echinospora) 		5 / 9 VAL A 182
LEU A 247
GLN A 258
THR A 265
VAL A 266
 None
 1.31A 6czmB-4z2yA:
undetectable
6czmC-4z2yA:
undetectable		 6czmB-4z2yA:
22.78
6czmC-4z2yA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4z2y CALO6
(Micromonospora
echinospora) 		5 / 10 VAL A 182
LEU A 247
GLN A 258
THR A 265
VAL A 266
 None
 1.33A 6czmE-4z2yA:
undetectable
6czmF-4z2yA:
undetectable		 6czmE-4z2yA:
22.78
6czmF-4z2yA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4z2y CALO6
(Micromonospora
echinospora) 		5 / 11 TRP A 254
ASP A 253
VAL A 211
ALA A 219
VAL A 204
 None
 1.39A 6hu9A-4z2yA:
undetectable
6hu9E-4z2yA:
undetectable
6hu9I-4z2yA:
undetectable		 6hu9A-4z2yA:
21.13
6hu9E-4z2yA:
18.98
6hu9I-4z2yA:
14.62