SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z31'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4z31 ROQUIN-2
(Homo
sapiens) 		5 / 12 LEU A 201
GLY A 193
PRO A 194
TYR A 273
PHE A 191
 None
UNX  A1001 ( 3.6A)
None
None
None
 1.16A 1fdsA-4z31A:
undetectable		 1fdsA-4z31A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4z31 ROQUIN-2
(Homo
sapiens) 		4 / 6 ALA A 249
LEU A 201
GLU A 279
LEU A 304
 None
 0.88A 1mt1D-4z31A:
undetectable
1mt1E-4z31A:
undetectable		 1mt1D-4z31A:
13.61
1mt1E-4z31A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 4z31 ROQUIN-2
(Homo
sapiens) 		5 / 12 LEU A 304
LEU A 246
VAL A 242
LEU A 201
ARG A 277
 None
 1.32A 2bxfB-4z31A:
2.7		 2bxfB-4z31A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFB_B_KANB401_1
(APH(2')-ID)		 4z31 ROQUIN-2
(Homo
sapiens) 		5 / 10 SER A 301
ASP A 307
HIS A 310
ASP A 281
TRP A 181
 None
 1.44A 4dfbB-4z31A:
0.3		 4dfbB-4z31A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_A_KANA401_1
(APH(2')-ID)		 4z31 ROQUIN-2
(Homo
sapiens) 		5 / 12 SER A 301
ASP A 307
HIS A 310
ASP A 281
TRP A 181
 None
 1.46A 4dfuA-4z31A:
0.0		 4dfuA-4z31A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_B_KANB402_1
(APH(2')-ID)		 4z31 ROQUIN-2
(Homo
sapiens) 		5 / 12 SER A 301
ASP A 307
HIS A 310
ASP A 281
TRP A 181
 None
 1.40A 4dfuB-4z31A:
undetectable		 4dfuB-4z31A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 4z31 ROQUIN-2
(Homo
sapiens) 		5 / 12 MET A 152
ILE A 360
LEU A 357
LEU A 105
LEU A 137
 None
 1.30A 4qynB-4z31A:
undetectable		 4qynB-4z31A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4z31 ROQUIN-2
(Homo
sapiens) 		5 / 12 LEU A 201
TYR A 273
LEU A 321
ILE A 317
HIS A 313
 None
 1.13A 5dv4A-4z31A:
undetectable		 5dv4A-4z31A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 4z31 ROQUIN-2
(Homo
sapiens) 		5 / 10 LEU A 158
VAL A 384
LEU A 388
PHE A 327
GLU A 165
 None
 1.39A 5tixB-4z31A:
undetectable		 5tixB-4z31A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4z31 ROQUIN-2
(Homo
sapiens) 		4 / 6 TRP A 181
GLY A 292
ALA A 183
LEU A 180
 None
 0.92A 6fosA-4z31A:
undetectable		 6fosA-4z31A:
13.29