SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z36'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4z36 LYSOPHOSPHATIDIC
ACID RECEPTOR
1,SOLUBLE CYTOCHROME
B562
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ALA A 134
VAL A 136
TRP A 271
 None
 0.95A 1grmA-4z36A:
undetectable		 1grmA-4z36A:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4z36 LYSOPHOSPHATIDIC
ACID RECEPTOR
1,SOLUBLE CYTOCHROME
B562
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ALA A 134
VAL A 136
TRP A 271
 None
 0.95A 1grmB-4z36A:
undetectable		 1grmB-4z36A:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4z36 LYSOPHOSPHATIDIC
ACID RECEPTOR
1,SOLUBLE CYTOCHROME
B562
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 132
ASN A 214
LEU A 275
TRP A 210
 ON3  A2000 ( 4.7A)
None
None
ON3  A2000 (-4.2A)
 1.14A 1ru9H-4z36A:
undetectable
1ru9L-4z36A:
undetectable		 1ru9H-4z36A:
17.75
1ru9L-4z36A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4z36 LYSOPHOSPHATIDIC
ACID RECEPTOR
1,SOLUBLE CYTOCHROME
B562
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 132
ASN A 214
LEU A 275
TRP A 210
 ON3  A2000 ( 4.7A)
None
None
ON3  A2000 (-4.2A)
 1.09A 1rukH-4z36A:
undetectable
1rukL-4z36A:
undetectable		 1rukH-4z36A:
17.75
1rukL-4z36A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4z36 LYSOPHOSPHATIDIC
ACID RECEPTOR
1,SOLUBLE CYTOCHROME
B562
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 201
ALA A 199
SER A 203
SER A 205
 None
ON3  A2000 ( 4.5A)
None
None
 1.00A 1tz8C-4z36A:
undetectable
1tz8D-4z36A:
undetectable		 1tz8C-4z36A:
13.79
1tz8D-4z36A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4z36 LYSOPHOSPHATIDIC
ACID RECEPTOR
1,SOLUBLE CYTOCHROME
B562
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ALA A1036
ALA A1035
ALA A1040
VAL A1016
ILE A1017
 None
 1.09A 3falA-4z36A:
undetectable		 3falA-4z36A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4z36 LYSOPHOSPHATIDIC
ACID RECEPTOR
1,SOLUBLE CYTOCHROME
B562
(Escherichia
coli;
Homo
sapiens) 		3 / 3 HIS A 227
HIS A 147
ILE A 228
 None
 0.77A 3u52A-4z36A:
2.5
3u52C-4z36A:
2.5		 3u52A-4z36A:
19.75
3u52C-4z36A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4z36 LYSOPHOSPHATIDIC
ACID RECEPTOR
1,SOLUBLE CYTOCHROME
B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 176
LEU A 127
GLY A 126
TYR A 102
ALA A  98
 None
1WV  A2001 ( 4.7A)
1WV  A2001 ( 4.0A)
None
None
 1.15A 4foxD-4z36A:
undetectable		 4foxD-4z36A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4z36 LYSOPHOSPHATIDIC
ACID RECEPTOR
1,SOLUBLE CYTOCHROME
B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 176
LEU A 127
GLY A 126
TYR A 102
ALA A  98
 None
1WV  A2001 ( 4.7A)
1WV  A2001 ( 4.0A)
None
None
 1.02A 5x66A-4z36A:
undetectable
5x66B-4z36A:
undetectable		 5x66A-4z36A:
21.59
5x66B-4z36A:
21.59