SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z37'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
4 / 7 LEU A2535
THR A2450
ASN A2524
TYR A2526
None
1.26A 1afsA-4z37A:
undetectable
1afsA-4z37A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
4 / 7 LEU A2535
THR A2450
ASN A2524
TYR A2526
None
1.27A 1afsB-4z37A:
undetectable
1afsB-4z37A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
4 / 8 GLY A2638
GLY A2551
PHE A2550
GLY A2554
None
0.73A 1d0vA-4z37A:
undetectable
1d0vA-4z37A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.15A 1ddrB-4z37A:
undetectable
1ddrB-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.12A 1ddsA-4z37A:
undetectable
1ddsA-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.15A 1ddsB-4z37A:
undetectable
1ddsB-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.06A 1dyiA-4z37A:
undetectable
1dyiA-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.08A 1dyiB-4z37A:
undetectable
1dyiB-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 9 GLY A2741
GLY A2677
ALA A2682
HIS A2753
ILE A2678
None
1.18A 1gtfD-4z37A:
undetectable
1gtfE-4z37A:
undetectable
1gtfD-4z37A:
8.15
1gtfE-4z37A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.10A 1jolA-4z37A:
undetectable
1jolA-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ALA A2777
ILE A2916
LEU A2918
PRO A2919
TYR A2908
None
1.05A 1jolB-4z37A:
undetectable
1jolB-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.10A 1jolB-4z37A:
undetectable
1jolB-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ALA A2618
SER A2589
GLY A2741
ILE A2756
LEU A2568
None
1.20A 1kglA-4z37A:
0.5
1kglA-4z37A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
4 / 7 GLN A2431
PHE A2923
MET A2824
ALA A2823
None
1.26A 1linA-4z37A:
undetectable
1linA-4z37A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 HIS A2690
VAL A2665
VAL A2694
TYR A2332
GLN A2687
None
1.18A 1n2xA-4z37A:
undetectable
1n2xA-4z37A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
4 / 7 LEU A2702
ILE A2706
PHE A2550
ILE A2628
None
0.91A 1oniB-4z37A:
1.7
1oniC-4z37A:
1.5
1oniB-4z37A:
12.58
1oniC-4z37A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.00A 1ra2A-4z37A:
undetectable
1ra2A-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.10A 1ra3A-4z37A:
undetectable
1ra3A-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
0.99A 1rd7B-4z37A:
undetectable
1rd7B-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ALA A2777
ILE A2916
LEU A2918
PRO A2919
TYR A2908
None
1.06A 1re7B-4z37A:
undetectable
1re7B-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.00A 1re7B-4z37A:
undetectable
1re7B-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.00A 1rx2A-4z37A:
undetectable
1rx2A-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.04A 1rx3A-4z37A:
undetectable
1rx3A-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ALA A2777
ILE A2916
LEU A2918
PRO A2919
TYR A2908
None
1.02A 1rx8A-4z37A:
undetectable
1rx8A-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.06A 1rx8A-4z37A:
undetectable
1rx8A-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.12A 1tdrA-4z37A:
undetectable
1tdrA-4z37A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 10 SER A2834
ALA A2777
LEU A2828
LEU A2855
LEU A2810
None
1.13A 2bxqA-4z37A:
undetectable
2bxqA-4z37A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_A_SAMA500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 10 SER A2696
GLY A2348
SER A2347
LEU A2693
GLN A2716
None
0.94A 2c2bA-4z37A:
1.1
2c2bB-4z37A:
undetectable
2c2bA-4z37A:
22.12
2c2bB-4z37A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_B_SAMB500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 10 LEU A2693
GLN A2716
SER A2696
GLY A2348
SER A2347
None
0.93A 2c2bA-4z37A:
1.1
2c2bB-4z37A:
undetectable
2c2bA-4z37A:
22.12
2c2bB-4z37A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_C_SAMC500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 10 SER A2696
GLY A2348
SER A2347
LEU A2693
GLN A2716
None
0.93A 2c2bC-4z37A:
0.0
2c2bD-4z37A:
0.0
2c2bC-4z37A:
22.12
2c2bD-4z37A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 11 SER A2696
GLY A2348
SER A2347
LEU A2693
GLN A2716
None
0.93A 2c2bE-4z37A:
undetectable
2c2bF-4z37A:
1.6
2c2bE-4z37A:
22.12
2c2bF-4z37A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_F_SAMF500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 10 LEU A2693
GLN A2716
SER A2696
GLY A2348
SER A2347
None
0.96A 2c2bE-4z37A:
undetectable
2c2bF-4z37A:
1.6
2c2bE-4z37A:
22.12
2c2bF-4z37A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 PHE A2415
LEU A2475
ALA A2391
PHE A2390
VAL A2563
None
0.98A 2g70B-4z37A:
undetectable
2g70B-4z37A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 PHE A2415
LEU A2475
ALA A2391
PHE A2390
VAL A2563
None
0.93A 2g72A-4z37A:
undetectable
2g72A-4z37A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 LEU A2414
ARG A2413
PHE A2923
GLY A2564
LEU A2338
None
1.20A 2lbdA-4z37A:
undetectable
2lbdA-4z37A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 LEU A2817
LEU A2781
LEU A2828
ILE A2813
VAL A2832
None
1.07A 2pnjA-4z37A:
2.2
2pnjA-4z37A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.08A 2zzaA-4z37A:
undetectable
2zzaA-4z37A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 11 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.08A 2zzaB-4z37A:
undetectable
2zzaB-4z37A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.08A 3dauA-4z37A:
undetectable
3dauA-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 9 ARG A2331
ALA A2682
VAL A2566
ILE A2503
GLY A2677
None
1.20A 3el4B-4z37A:
undetectable
3el4B-4z37A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
4 / 6 ARG A2331
GLY A2330
GLU A2417
GLU A2421
None
0.85A 3k9fA-4z37A:
undetectable
3k9fB-4z37A:
undetectable
3k9fD-4z37A:
undetectable
3k9fA-4z37A:
23.95
3k9fB-4z37A:
23.95
3k9fD-4z37A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 LEU A2842
SER A2844
PHE A2845
LEU A2830
ASP A2854
None
1.24A 3ko0A-4z37A:
undetectable
3ko0B-4z37A:
undetectable
3ko0C-4z37A:
undetectable
3ko0D-4z37A:
undetectable
3ko0A-4z37A:
9.61
3ko0B-4z37A:
9.61
3ko0C-4z37A:
9.61
3ko0D-4z37A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 11 LEU A2830
ASP A2854
LEU A2842
SER A2844
PHE A2845
None
1.27A 3ko0A-4z37A:
undetectable
3ko0B-4z37A:
undetectable
3ko0I-4z37A:
undetectable
3ko0J-4z37A:
undetectable
3ko0A-4z37A:
9.61
3ko0B-4z37A:
9.61
3ko0I-4z37A:
9.61
3ko0J-4z37A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 LEU A2830
ASP A2854
LEU A2842
SER A2844
PHE A2845
None
1.22A 3ko0K-4z37A:
undetectable
3ko0L-4z37A:
undetectable
3ko0M-4z37A:
undetectable
3ko0N-4z37A:
undetectable
3ko0K-4z37A:
9.61
3ko0L-4z37A:
9.61
3ko0M-4z37A:
9.61
3ko0N-4z37A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 LEU A2842
SER A2844
PHE A2845
LEU A2830
ASP A2854
None
1.16A 3ko0M-4z37A:
undetectable
3ko0N-4z37A:
undetectable
3ko0O-4z37A:
undetectable
3ko0P-4z37A:
undetectable
3ko0M-4z37A:
9.61
3ko0N-4z37A:
9.61
3ko0O-4z37A:
9.61
3ko0P-4z37A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 LEU A2830
ASP A2854
LEU A2842
SER A2844
PHE A2845
None
1.24A 3ko0M-4z37A:
undetectable
3ko0N-4z37A:
undetectable
3ko0O-4z37A:
undetectable
3ko0P-4z37A:
undetectable
3ko0M-4z37A:
9.61
3ko0N-4z37A:
9.61
3ko0O-4z37A:
9.61
3ko0P-4z37A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.04A 3ql0A-4z37A:
undetectable
3ql0A-4z37A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
4 / 5 PHE A2444
GLY A2487
CYH A2515
HIS A2509
None
1.26A 3r0lD-4z37A:
undetectable
3r0lD-4z37A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
4 / 5 ILE A2647
THR A2711
THR A2657
PHE A2713
None
1.11A 3snfA-4z37A:
undetectable
3snfA-4z37A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
3 / 3 ASN A2901
ALA A2823
ARG A2827
None
0.87A 3tj7C-4z37A:
undetectable
3tj7D-4z37A:
undetectable
3tj7C-4z37A:
15.63
3tj7D-4z37A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ASN A2668
ILE A2669
GLY A2560
GLY A2670
LEU A2345
None
1.05A 3uboB-4z37A:
undetectable
3uboB-4z37A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 11 GLN A2877
GLY A2872
ALA A2860
GLY A2899
GLU A2825
None
1.34A 4a6nA-4z37A:
undetectable
4a6nA-4z37A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
6 / 10 GLY A2521
ALA A2520
ILE A2503
ILE A2756
LEU A2685
ILE A2325
None
1.15A 4dt8B-4z37A:
undetectable
4dt8B-4z37A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 10 ALA A2520
ILE A2503
ILE A2756
LEU A2685
ILE A2325
None
1.08A 4dtaA-4z37A:
undetectable
4dtaA-4z37A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.14A 4ej1B-4z37A:
undetectable
4ej1B-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.15A 4gh8A-4z37A:
undetectable
4gh8A-4z37A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 GLU A2421
GLY A2562
ALA A2675
LEU A2338
THR A2565
None
1.19A 4hytA-4z37A:
undetectable
4hytA-4z37A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 GLU A2421
GLY A2562
ALA A2675
LEU A2338
THR A2565
None
1.20A 4hytC-4z37A:
undetectable
4hytC-4z37A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ASN A2668
ILE A2669
GLY A2560
GLY A2670
LEU A2345
None
1.09A 4jkuB-4z37A:
undetectable
4jkuB-4z37A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ASN A2668
ILE A2669
GLY A2560
GLY A2670
LEU A2345
None
1.09A 4k9cA-4z37A:
undetectable
4k9cA-4z37A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ASN A2668
ILE A2669
GLY A2560
GLY A2670
LEU A2345
None
1.09A 4k9cB-4z37A:
undetectable
4k9cB-4z37A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 CYH A2496
HIS A2631
THR A2633
HIS A2671
GLY A2746
None
0.52A 4ls7A-4z37A:
48.1
4ls7A-4z37A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 CYH A2496
HIS A2631
THR A2633
HIS A2671
GLY A2746
None
0.51A 4ls7A-4z37A:
48.1
4ls7B-4z37A:
47.8
4ls7A-4z37A:
21.69
4ls7B-4z37A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
4 / 4 THR A2624
ARG A2586
GLU A2757
VAL A2620
None
1.37A 4odoC-4z37A:
0.3
4odoC-4z37A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ALA A2777
ILE A2916
LEU A2918
PRO A2919
TYR A2908
None
1.05A 4p3qA-4z37A:
undetectable
4p3qA-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ALA A2752
HIS A2753
ILE A2756
ILE A2678
HIS A2631
None
1.20A 4qe6A-4z37A:
0.0
4qe6A-4z37A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.06A 4qi9A-4z37A:
undetectable
4qi9A-4z37A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.05A 4qi9B-4z37A:
undetectable
4qi9B-4z37A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.06A 4qleA-4z37A:
undetectable
4qleA-4z37A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 11 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.09A 4qleB-4z37A:
undetectable
4qleB-4z37A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 11 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.05A 4qlfA-4z37A:
undetectable
4qlfA-4z37A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.05A 4qlgA-4z37A:
undetectable
4qlgA-4z37A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.09A 4qlgB-4z37A:
undetectable
4qlgB-4z37A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.05A 4rgcA-4z37A:
undetectable
4rgcA-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_ACTA502_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
4 / 4 LYS A2898
ARG A2827
GLY A2858
ASP A2894
None
1.28A 4ryaA-4z37A:
undetectable
4ryaA-4z37A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 PHE A2415
GLY A2677
LEU A2500
VAL A2754
THR A2588
None
1.15A 4wnwA-4z37A:
undetectable
4wnwA-4z37A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.03A 4x5fA-4z37A:
undetectable
4x5fA-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.03A 4x5fB-4z37A:
undetectable
4x5fB-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.04A 4x5gA-4z37A:
undetectable
4x5gA-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.03A 4x5gB-4z37A:
undetectable
4x5gB-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.05A 4x5hA-4z37A:
undetectable
4x5hA-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 LEU A2686
VAL A2566
ILE A2678
ILE A2325
GLY A2583
None
0.88A 4y8wC-4z37A:
undetectable
4y8wC-4z37A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 SER A2418
VAL A2681
ILE A2325
ILE A2678
VAL A2387
None
0.85A 4y8wC-4z37A:
undetectable
4y8wC-4z37A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 GLY A2748
TYR A2526
PHE A2365
ILE A2355
GLY A2381
None
1.14A 4zdyA-4z37A:
undetectable
4zdyA-4z37A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
4 / 7 TYR A2526
PHE A2365
ILE A2355
GLY A2381
None
0.90A 4ze3A-4z37A:
undetectable
4ze3A-4z37A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 11 TYR A2428
ASP A2579
VAL A2441
ALA A2324
ILE A2325
None
1.16A 5d75A-4z37A:
undetectable
5d75A-4z37A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.10A 5e8qB-4z37A:
undetectable
5e8qB-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.11A 5eajB-4z37A:
undetectable
5eajB-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
4 / 8 TYR A2526
PHE A2365
ILE A2355
GLY A2381
None
0.92A 5esjA-4z37A:
undetectable
5esjA-4z37A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 11 TYR A2428
ASP A2579
VAL A2441
ALA A2324
ILE A2325
None
1.10A 5gpgA-4z37A:
undetectable
5gpgA-4z37A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.10A 5hi6A-4z37A:
undetectable
5hi6A-4z37A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.15A 5hi6B-4z37A:
undetectable
5hi6B-4z37A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
3 / 3 CYH A2547
LYS A2548
HIS A2698
None
1.13A 5js5A-4z37A:
undetectable
5js5A-4z37A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 9 ASP A2493
ILE A2447
GLY A2522
ILE A2678
THR A2476
None
1.31A 5kr2A-4z37A:
undetectable
5kr2A-4z37A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 9 ASP A2493
ILE A2447
GLY A2522
ILE A2678
THR A2476
None
1.27A 5kr2C-4z37A:
undetectable
5kr2C-4z37A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
3 / 3 HIS A2469
SER A2471
ARG A2478
None
0.75A 5u63A-4z37A:
undetectable
5u63A-4z37A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ILE A2678
ALA A2502
LEU A2568
ILE A2756
LEU A2685
None
1.13A 5ujxB-4z37A:
undetectable
5ujxB-4z37A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 PHE A2550
PHE A2713
GLY A2638
HIS A2753
PHE A2650
None
1.28A 5v5zA-4z37A:
undetectable
5v5zA-4z37A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
5 / 12 ALA A2682
VAL A2422
CYH A2419
TYR A2428
ASP A2579
None
1.45A 5vlmD-4z37A:
0.6
5vlmD-4z37A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
3 / 3 MET A2884
ASP A2903
ARG A2827
None
1.18A 5z6jA-4z37A:
undetectable
5z6jA-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
3 / 3 MET A2884
ASP A2903
ARG A2827
None
1.09A 5z6kA-4z37A:
undetectable
5z6kA-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis)
4 / 6 LEU A2918
THR A2816
GLY A2427
ARG A2821
None
1.38A 6gtqB-4z37A:
undetectable
6gtqD-4z37A:
undetectable
6gtqB-4z37A:
15.49
6gtqD-4z37A:
5.97