SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z38'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 9 GLY A 576
GLY A 748
ILE A 747
PRO A 559
ILE A 556
 FMN  A 900 (-3.5A)
None
None
None
None
 1.06A 1hxwA-4z38A:
undetectable		 1hxwA-4z38A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 10 ALA A 570
LEU A 528
PRO A 529
ALA A 552
GLY A 554
 None
None
None
None
FMN  A 900 (-3.2A)
 1.30A 1mjqG-4z38A:
undetectable
1mjqH-4z38A:
undetectable		 1mjqG-4z38A:
13.53
1mjqH-4z38A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 12 GLY A 576
GLY A 748
ILE A 747
PRO A 559
ILE A 556
 FMN  A 900 (-3.5A)
None
None
None
None
 0.87A 1muiB-4z38A:
undetectable		 1muiB-4z38A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 11 GLU A 379
GLY A 371
GLY A 351
ILE A 377
ALA A 373
 None
None
None
None
FMN  A 900 ( 3.8A)
 0.71A 1x7pA-4z38A:
undetectable
1x7pB-4z38A:
2.1		 1x7pA-4z38A:
20.21
1x7pB-4z38A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 10 GLY A 576
GLY A 748
ILE A 747
PRO A 559
ILE A 556
 FMN  A 900 (-3.5A)
None
None
None
None
 0.91A 2aquA-4z38A:
undetectable		 2aquA-4z38A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 11 GLY A 576
GLY A 748
ILE A 747
PRO A 559
ILE A 556
 FMN  A 900 (-3.5A)
None
None
None
None
 0.90A 2aquB-4z38A:
undetectable		 2aquB-4z38A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 4z38 MLNA
(Bacillus
velezensis) 		6 / 12 MET A 752
PHE A 566
ALA A 342
ILE A 550
ILE A 510
LEU A 344
 None
 1.39A 2bjfA-4z38A:
undetectable		 2bjfA-4z38A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 12 LEU A 414
LEU A 401
GLY A 371
SER A 429
ALA A 355
 None
None
None
FMN  A 900 (-2.6A)
None
 1.14A 2bm9D-4z38A:
undetectable		 2bm9D-4z38A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4z38 MLNA
(Bacillus
velezensis) 		4 / 7 GLY A 721
PRO A 722
ILE A 600
GLY A 725
 FMN  A 900 ( 4.8A)
None
None
None
 0.88A 2jklC-4z38A:
undetectable		 2jklC-4z38A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4z38 MLNA
(Bacillus
velezensis) 		4 / 7 GLY A 721
PRO A 722
ILE A 600
GLY A 725
 FMN  A 900 ( 4.8A)
None
None
None
 0.86A 2jklD-4z38A:
undetectable		 2jklD-4z38A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4z38 MLNA
(Bacillus
velezensis) 		4 / 7 GLY A 721
PRO A 722
ILE A 600
GLY A 725
 FMN  A 900 ( 4.8A)
None
None
None
 0.87A 2jklF-4z38A:
undetectable		 2jklF-4z38A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 12 GLY A 576
GLY A 748
ILE A 747
PRO A 559
ILE A 556
 FMN  A 900 (-3.5A)
None
None
None
None
 0.95A 2qhcB-4z38A:
undetectable		 2qhcB-4z38A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4z38 MLNA
(Bacillus
velezensis) 		3 / 3 MET A 366
VAL A 423
GLU A 427
 None
None
FMN  A 900 ( 4.8A)
 0.47A 2x9gA-4z38A:
undetectable		 2x9gA-4z38A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 10 GLY A 576
GLY A 748
ILE A 747
PRO A 559
ILE A 556
 FMN  A 900 (-3.5A)
None
None
None
None
 0.95A 3ekyA-4z38A:
undetectable		 3ekyA-4z38A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4z38 MLNA
(Bacillus
velezensis) 		4 / 6 ILE A 578
THR A 755
PHE A 566
TYR A 343
 None
 1.31A 3elzB-4z38A:
undetectable		 3elzB-4z38A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 4z38 MLNA
(Bacillus
velezensis) 		3 / 3 GLU A 613
GLY A 615
THR A 616
 None
 0.53A 3iazA-4z38A:
undetectable		 3iazA-4z38A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 4z38 MLNA
(Bacillus
velezensis) 		3 / 3 HIS A 457
ARG A 424
GLU A 422
 None
 0.97A 3qf1A-4z38A:
undetectable		 3qf1A-4z38A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4z38 MLNA
(Bacillus
velezensis) 		4 / 8 SER A 354
SER A 353
MET A 348
GLY A 398
 None
None
FMN  A 900 (-3.6A)
None
 0.98A 4af0A-4z38A:
21.0		 4af0A-4z38A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 12 ALA A 565
GLY A 557
GLY A 555
LEU A 724
ALA A 562
 None
None
FMN  A 900 (-3.5A)
None
None
 1.14A 4lg1C-4z38A:
undetectable		 4lg1C-4z38A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 12 GLY A 371
GLY A 351
ASN A 400
GLY A 368
LEU A 367
 None
None
FMN  A 900 ( 3.3A)
None
None
 1.05A 4n48A-4z38A:
undetectable		 4n48A-4z38A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 11 GLY A 576
GLY A 748
ILE A 747
PRO A 559
ILE A 556
 FMN  A 900 (-3.5A)
None
None
None
None
 0.99A 4njvC-4z38A:
undetectable		 4njvC-4z38A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 4z38 MLNA
(Bacillus
velezensis) 		3 / 3 GLN A 445
HIS A 457
ARG A 424
 None
 1.14A 4qyqA-4z38A:
undetectable		 4qyqA-4z38A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 4z38 MLNA
(Bacillus
velezensis) 		3 / 3 GLN A 445
HIS A 457
ARG A 424
 None
 1.14A 4qyqB-4z38A:
undetectable		 4qyqB-4z38A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 9 ALA A 565
SER A 577
ILE A 578
GLY A 554
ALA A 553
 None
FMN  A 900 (-2.6A)
None
FMN  A 900 (-3.2A)
FMN  A 900 ( 4.3A)
 1.26A 4r1zA-4z38A:
undetectable		 4r1zA-4z38A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4z38 MLNA
(Bacillus
velezensis) 		4 / 6 ILE A 481
PRO A 478
HIS A 542
ILE A 502
 None
 0.91A 4zj8A-4z38A:
undetectable		 4zj8A-4z38A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4z38 MLNA
(Bacillus
velezensis) 		4 / 4 LEU A 344
ILE A 573
GLY A 346
ILE A 556
 None
None
FMN  A 900 (-3.4A)
None
 0.85A 5dzk3-4z38A:
undetectable
5dzkm-4z38A:
2.5		 5dzk3-4z38A:
13.33
5dzkm-4z38A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4z38 MLNA
(Bacillus
velezensis) 		4 / 5 ILE A 573
GLY A 346
ILE A 556
LEU A 344
 None
FMN  A 900 (-3.4A)
None
None
 0.86A 5dzkB-4z38A:
2.3
5dzkI-4z38A:
2.8
5dzkW-4z38A:
undetectable		 5dzkB-4z38A:
19.75
5dzkI-4z38A:
17.06
5dzkW-4z38A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4z38 MLNA
(Bacillus
velezensis) 		4 / 5 ILE A 573
GLY A 346
ILE A 556
LEU A 344
 None
FMN  A 900 (-3.4A)
None
None
 0.85A 5dzki-4z38A:
2.6
5dzkj-4z38A:
2.7
5dzkx-4z38A:
undetectable		 5dzki-4z38A:
17.06
5dzkj-4z38A:
17.06
5dzkx-4z38A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4z38 MLNA
(Bacillus
velezensis) 		4 / 4 ILE A 359
GLY A 368
ILE A 387
LEU A 361
 None
 0.88A 5dzkl-4z38A:
2.6
5dzkz-4z38A:
undetectable		 5dzkl-4z38A:
17.06
5dzkz-4z38A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4z38 MLNA
(Bacillus
velezensis) 		4 / 6 GLU A 411
ALA A 436
LEU A 438
TYR A 431
 None
 1.15A 5phhA-4z38A:
undetectable		 5phhA-4z38A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 12 GLY A 576
GLY A 748
ILE A 747
PRO A 559
ILE A 556
 FMN  A 900 (-3.5A)
None
None
None
None
 1.01A 5t2zA-4z38A:
undetectable		 5t2zA-4z38A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 12 GLY A 576
GLY A 748
ILE A 747
SER A 561
ILE A 556
 FMN  A 900 (-3.5A)
None
None
None
None
 1.08A 5t2zA-4z38A:
undetectable		 5t2zA-4z38A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4z38 MLNA
(Bacillus
velezensis) 		5 / 9 THR A 598
GLY A 599
GLY A 725
LEU A 724
SER A 723
 None
None
None
None
FMN  A 900 (-2.6A)
 1.31A 5vw4A-4z38A:
undetectable		 5vw4A-4z38A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4z38 MLNA
(Bacillus
velezensis) 		4 / 5 LEU A 634
GLN A 636
PHE A 635
PHE A 627
 None
 1.38A 6nmpP-4z38A:
undetectable
6nmpW-4z38A:
undetectable		 6nmpP-4z38A:
17.97
6nmpW-4z38A:
8.43