SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z3k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
5 / 12 GLY A  11
ARG A  39
ARG A  14
ASP A  66
ALA A  98
NAP  A 801 (-3.2A)
SO4  A 803 ( 2.7A)
NAP  A 801 (-3.8A)
NAP  A 801 (-3.8A)
NAP  A 801 (-3.8A)
1.10A 2bm9A-4z3kA:
6.9
2bm9A-4z3kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
5 / 12 LEU A  27
LEU A   2
GLN A  90
ALA A   5
LEU A  58
None
1.31A 3gwuA-4z3kA:
undetectable
3gwuA-4z3kA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
6 / 12 LEU A  27
GLY A   1
LEU A   2
GLN A  90
ALA A   5
LEU A  58
None
1.26A 3gwvA-4z3kA:
undetectable
3gwvA-4z3kA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
5 / 12 GLY A  72
LEU A 131
SER A 127
VAL A  63
VAL A  35
None
0.97A 4htfA-4z3kA:
5.3
4htfA-4z3kA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
5 / 12 GLY A  72
LEU A 131
SER A 127
VAL A  63
VAL A  35
None
0.99A 4htfB-4z3kA:
5.9
4htfB-4z3kA:
26.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HWK_A_SFYA807_0
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
11 / 11 SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
MET A 202
GLN A 203
ALA A 206
MET A 215
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
NAP  A 801 (-3.5A)
4KL  A 802 ( 3.2A)
4KL  A 802 ( 4.3A)
None
0.55A 4hwkA-4z3kA:
45.3
4hwkA-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
5 / 11 LEU A 101
CYH A 168
PHE A 161
TRP A 164
MET A 202
None
None
None
None
NAP  A 801 (-3.5A)
1.43A 4hwkB-4z3kA:
45.3
4hwkB-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
11 / 11 LEU A 101
SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
MET A 202
GLN A 203
ALA A 206
None
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
NAP  A 801 (-3.5A)
4KL  A 802 ( 3.2A)
4KL  A 802 ( 4.3A)
0.32A 4hwkB-4z3kA:
45.3
4hwkB-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
5 / 12 LEU A 101
CYH A 168
PHE A 161
TRP A 164
MET A 202
None
None
None
None
NAP  A 801 (-3.5A)
1.43A 4hwkC-4z3kA:
45.5
4hwkC-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
12 / 12 LEU A 101
SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
MET A 202
GLN A 203
ALA A 206
MET A 215
None
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
NAP  A 801 (-3.5A)
4KL  A 802 ( 3.2A)
4KL  A 802 ( 4.3A)
None
0.50A 4hwkC-4z3kA:
45.5
4hwkC-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
11 / 11 LEU A 101
SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
MET A 202
GLN A 203
ALA A 206
None
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
NAP  A 801 (-3.5A)
4KL  A 802 ( 3.2A)
4KL  A 802 ( 4.3A)
0.27A 4hwkD-4z3kA:
45.5
4hwkD-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7U_A_YTZA802_1
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
10 / 10 SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
MET A 202
GLN A 203
MET A 215
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
NAP  A 801 (-3.5A)
4KL  A 802 ( 3.2A)
None
0.58A 4j7uA-4z3kA:
45.3
4j7uA-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7U_B_YTZB802_1
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
10 / 10 SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
MET A 202
GLN A 203
MET A 215
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
NAP  A 801 (-3.5A)
4KL  A 802 ( 3.2A)
None
0.57A 4j7uB-4z3kA:
45.4
4j7uB-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7U_C_YTZC802_1
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
10 / 10 SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
MET A 202
GLN A 203
MET A 215
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
NAP  A 801 (-3.5A)
4KL  A 802 ( 3.2A)
None
0.57A 4j7uC-4z3kA:
45.2
4j7uC-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
8 / 8 SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
GLN A 203
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
0.32A 4j7uD-4z3kA:
45.3
4j7uD-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
11 / 12 SER A 154
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
GLN A 203
ALA A 206
ASP A 214
MET A 215
GLY A 218
4KL  A 802 (-2.6A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
4KL  A 802 ( 4.3A)
None
None
None
0.63A 4j7xA-4z3kA:
45.1
4j7xA-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
7 / 12 SER A 154
LEU A 155
CYH A 156
PHE A 161
PRO A 197
GLN A 203
ASP A 212
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
None
1.08A 4j7xA-4z3kA:
45.1
4j7xA-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
11 / 12 SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
GLN A 203
ALA A 206
MET A 215
GLY A 218
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
4KL  A 802 ( 4.3A)
None
None
0.56A 4j7xA-4z3kA:
45.1
4j7xA-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
12 / 12 SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
GLN A 203
ALA A 206
MET A 215
GLY A 218
LEU A 219
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
4KL  A 802 ( 4.3A)
None
None
4KL  A 802 (-4.9A)
0.47A 4j7xB-4z3kA:
45.2
4j7xB-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
3 / 3 LEU A 101
MET A 202
ASP A 214
None
NAP  A 801 (-3.5A)
None
0.20A 4j7xB-4z3kA:
45.2
4j7xB-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
12 / 12 SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
GLN A 203
ASP A 212
ASP A 214
MET A 215
GLY A 218
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
None
None
None
None
0.69A 4j7xF-4z3kA:
45.0
4j7xF-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
6 / 12 SER A 154
LEU A 155
PHE A 161
PRO A 197
GLN A 203
ASP A 212
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
None
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
None
1.16A 4j7xF-4z3kA:
45.0
4j7xF-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
6 / 12 LEU A 101
CYH A 168
PHE A 161
TRP A 164
ASP A 212
MET A 215
None
1.44A 4j7xJ-4z3kA:
45.3
4j7xJ-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
12 / 12 LEU A 101
SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
GLN A 203
ASP A 212
ASP A 214
MET A 215
None
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
None
None
None
0.60A 4j7xJ-4z3kA:
45.3
4j7xJ-4z3kA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
6 / 12 SER A 154
LEU A 155
PHE A 161
PRO A 197
GLN A 203
ASP A 212
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
None
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
None
1.05A 4j7xJ-4z3kA:
45.3
4j7xJ-4z3kA:
94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
5 / 9 LEU A   9
GLY A  17
LEU A  20
LEU A 238
ALA A 235
None
1.02A 5dqfA-4z3kA:
undetectable
5dqfA-4z3kA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
4 / 8 SER A  26
ALA A  25
LEU A  23
LEU A  20
None
1.16A 5dzkd-4z3kA:
undetectable
5dzkr-4z3kA:
undetectable
5dzkd-4z3kA:
22.89
5dzkr-4z3kA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
3 / 3 LEU A 129
LEU A 125
TRP A 121
None
0.89A 5nwuA-4z3kA:
undetectable
5nwuA-4z3kA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
5 / 12 LEU A 238
LEU A  23
LEU A  24
ILE A 152
LEU A   9
None
None
None
NAP  A 801 (-4.5A)
None
0.86A 5toaA-4z3kA:
undetectable
5toaA-4z3kA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)
4z3k SEPIAPTERIN
REDUCTASE

(Homo
sapiens)
4 / 8 ILE A  95
LEU A 241
ILE A 152
THR A 148
None
None
NAP  A 801 (-4.5A)
None
0.64A 5uihA-4z3kA:
undetectable
5uihA-4z3kA:
15.21