SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 11 GLY A 400
ASN A 464
ARG A 462
GLU A 466
VAL A 326
 None
None
CAC  A 508 (-2.5A)
CAC  A 508 ( 3.5A)
None
 1.38A 2fl5A-4z3nA:
undetectable
2fl5B-4z3nA:
undetectable
2fl5F-4z3nA:
undetectable		 2fl5A-4z3nA:
17.79
2fl5B-4z3nA:
18.75
2fl5F-4z3nA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		4 / 8 MET A 289
ALA A 288
TYR A 277
TYR A 436
 None
None
OLC  A 501 (-3.6A)
None
 0.80A 2zm9A-4z3nA:
undetectable		 2zm9A-4z3nA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 ALA A 446
GLY A 442
HIS A 413
LEU A 448
SER A 389
 None
None
OLC  A 501 (-4.2A)
OLC  A 505 ( 4.7A)
None
 0.96A 3bxoA-4z3nA:
undetectable		 3bxoA-4z3nA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 ALA A 446
GLY A 442
HIS A 413
LEU A 448
SER A 389
 None
None
OLC  A 501 (-4.2A)
OLC  A 505 ( 4.7A)
None
 1.03A 3bxoB-4z3nA:
undetectable		 3bxoB-4z3nA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 11 THR A 127
VAL A 128
VAL A  74
LEU A 141
TYR A 156
 None
 1.44A 3elzB-4z3nA:
undetectable		 3elzB-4z3nA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 LEU A 314
GLY A 260
GLY A  93
SER A  94
ALA A  83
 None
None
None
None
OLC  A 507 ( 3.9A)
 1.14A 3ou6B-4z3nA:
undetectable		 3ou6B-4z3nA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 LEU A 314
GLY A 260
GLY A  93
SER A  94
ALA A  83
 None
None
None
None
OLC  A 507 ( 3.9A)
 1.14A 3ou7B-4z3nA:
undetectable		 3ou7B-4z3nA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 ALA A 446
GLY A 442
HIS A 413
LEU A 448
SER A 389
 None
None
OLC  A 501 (-4.2A)
OLC  A 505 ( 4.7A)
None
 1.05A 3pfgA-4z3nA:
undetectable		 3pfgA-4z3nA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 THR A 315
GLY A 318
ARG A  98
GLY A 101
SER A  94
 None
 1.27A 3tkaA-4z3nA:
undetectable		 3tkaA-4z3nA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		3 / 3 GLN A 375
PHE A 292
TYR A 277
 OLC  A 501 ( 4.0A)
OLC  A 501 ( 4.5A)
OLC  A 501 (-3.6A)
 0.86A 3ucjB-4z3nA:
undetectable		 3ucjB-4z3nA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		3 / 3 GLN A 375
PHE A 292
TYR A 277
 OLC  A 501 ( 4.0A)
OLC  A 501 ( 4.5A)
OLC  A 501 (-3.6A)
 0.90A 3ucjA-4z3nA:
undetectable		 3ucjA-4z3nA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 LEU A 424
VAL A 435
GLY A 438
ALA A 439
SER A 417
 None
None
None
OLC  A 501 (-3.3A)
OLC  A 501 (-3.4A)
 1.10A 4rrwC-4z3nA:
undetectable		 4rrwC-4z3nA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 LEU A 424
VAL A 435
GLY A 438
ALA A 439
SER A 417
 None
None
None
OLC  A 501 (-3.3A)
OLC  A 501 (-3.4A)
 1.10A 4rrzC-4z3nA:
undetectable		 4rrzC-4z3nA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 GLY A 234
MET A 233
PHE A  24
GLY A 101
LEU A 105
 None
 1.22A 4ze1A-4z3nA:
0.7		 4ze1A-4z3nA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		4 / 8 SER A 158
TYR A 150
ALA A  69
GLY A  72
 None
 0.87A 5albL-4z3nA:
undetectable		 5albL-4z3nA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		6 / 12 GLY A 318
ILE A 100
LEU A  96
THR A 315
GLY A 179
PHE A  24
 None
 1.35A 5d4uA-4z3nA:
undetectable		 5d4uA-4z3nA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 LEU A 453
ALA A 450
LEU A 407
ILE A 416
GLY A 442
 None
 1.06A 5gs4A-4z3nA:
undetectable		 5gs4A-4z3nA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 ILE A 147
LEU A 138
GLU A 153
ALA A 214
GLY A 212
 None
None
None
OLC  A 506 ( 3.9A)
None
 0.99A 5uxdB-4z3nA:
undetectable		 5uxdB-4z3nA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 9 GLY A 260
ALA A 262
GLY A  91
LEU A  95
SER A  94
 None
 0.94A 5vw4A-4z3nA:
undetectable		 5vw4A-4z3nA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 GLY A  80
ILE A 126
TYR A 155
LEU A 137
GLY A 130
 OLC  A 507 ( 3.8A)
None
None
None
None
 1.31A 6bp4B-4z3nA:
undetectable		 6bp4B-4z3nA:
20.08