SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 8 TYR A1229
GLY A1210
LEU A1482
VAL A1238
 None
 1.18A 1gsfA-4z3oA:
undetectable		 1gsfA-4z3oA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 8 TYR A1229
GLY A1210
LEU A1482
VAL A1238
 None
 1.18A 1gsfB-4z3oA:
undetectable		 1gsfB-4z3oA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 8 TYR A1229
GLY A1210
LEU A1482
VAL A1238
 None
 1.18A 1gsfD-4z3oA:
undetectable		 1gsfD-4z3oA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		5 / 12 LEU A1405
ILE A1419
ILE A1379
LEU A1378
HIS A1373
 None
 1.02A 1kyvA-4z3oA:
2.4
1kyvE-4z3oA:
2.3		 1kyvA-4z3oA:
13.04
1kyvE-4z3oA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		5 / 12 ILE A1379
LEU A1378
HIS A1373
LEU A1405
ILE A1419
 None
 1.00A 1kyvB-4z3oA:
undetectable
1kyvC-4z3oA:
2.7		 1kyvB-4z3oA:
13.04
1kyvC-4z3oA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		5 / 12 ILE A1379
LEU A1378
HIS A1373
LEU A1405
ILE A1419
 None
 1.02A 1kyvC-4z3oA:
2.6
1kyvD-4z3oA:
undetectable		 1kyvC-4z3oA:
13.04
1kyvD-4z3oA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		5 / 12 ILE A1379
LEU A1378
HIS A1373
LEU A1405
ILE A1419
 None
 1.00A 1kyvD-4z3oA:
undetectable
1kyvE-4z3oA:
2.3		 1kyvD-4z3oA:
13.04
1kyvE-4z3oA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		5 / 12 PRO A1039
TYR A1023
ARG A1028
HIS A1076
HIS A1074
 None
 1.44A 1tmxB-4z3oA:
undetectable		 1tmxB-4z3oA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		3 / 3 ILE A1225
ASP A1212
PHE A1213
 None
 0.57A 1uwjB-4z3oA:
undetectable		 1uwjB-4z3oA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		5 / 10 ILE A1178
GLY A1341
HIS A1181
PRO A1179
ILE A1342
 None
 1.33A 2y7wB-4z3oA:
undetectable		 2y7wB-4z3oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 6 ARG A1478
PHE A1213
TYR A1261
PRO A1211
 None
 1.36A 3jqaA-4z3oA:
2.8		 3jqaA-4z3oA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 6 ARG A1478
PHE A1213
TYR A1261
PRO A1211
 None
 1.28A 3jqaC-4z3oA:
2.4		 3jqaC-4z3oA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 6 ARG A1478
PHE A1213
TYR A1261
PRO A1211
 None
 1.31A 3jqaD-4z3oA:
undetectable		 3jqaD-4z3oA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 6 ILE A1219
HIS A1181
PRO A1209
LEU A1482
 None
 1.26A 3oi8A-4z3oA:
undetectable		 3oi8A-4z3oA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 6 GLY A1377
ARG A1443
GLU A1438
ARG A1371
 None
 1.21A 4bqfA-4z3oA:
undetectable		 4bqfA-4z3oA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 7 GLY A 434
ASP A 435
GLY A 457
GLU A 475
 None
 0.24A 4koeA-4z3oA:
57.9
4koeB-4z3oA:
57.4
4koeD-4z3oA:
32.0		 4koeA-4z3oA:
66.85
4koeB-4z3oA:
66.85
4koeD-4z3oA:
91.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 7 SER A1080
GLY A 434
GLY A 457
GLU A 475
 None
 0.65A 4koeA-4z3oA:
57.9
4koeB-4z3oA:
57.4
4koeD-4z3oA:
32.0		 4koeA-4z3oA:
66.85
4koeB-4z3oA:
66.85
4koeD-4z3oA:
91.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 6 ASP A1177
GLY A1166
PRO A1214
THR A1215
 None
 1.03A 4l1aB-4z3oA:
undetectable		 4l1aB-4z3oA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 8 GLU A1290
GLU A1301
GLN A1253
ILE A1254
 None
 0.84A 4mj8A-4z3oA:
undetectable		 4mj8A-4z3oA:
13.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		3 / 5 GLY A 434
GLY A 457
GLU A 475
 None
 0.17A 4z2eA-4z3oA:
53.7
4z2eD-4z3oA:
25.9		 4z2eA-4z3oA:
35.84
4z2eD-4z3oA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 7 GLY A 434
ASP A 435
GLY A 457
GLU A 475
 None
 0.43A 4z53A-4z3oA:
58.6
4z53B-4z3oA:
57.9		 4z53A-4z3oA:
100.00
4z53B-4z3oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 7 GLY A 434
GLY A 457
GLU A 475
SER A1080
 None
 0.72A 4z53A-4z3oA:
58.6
4z53B-4z3oA:
57.9		 4z53A-4z3oA:
100.00
4z53B-4z3oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		4 / 5 HIS A 534
ILE A 502
ILE A 501
TYR A 430
 None
 1.24A 5dnuA-4z3oA:
3.9		 5dnuA-4z3oA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		5 / 9 GLN A 450
LEU A 603
ALA A 441
VAL A 432
ALA A 538
 None
 1.27A 5g44A-4z3oA:
undetectable		 5g44A-4z3oA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		3 / 3 ARG A1028
THR A 509
ASP A 510
 None
 0.74A 5g5gA-4z3oA:
1.1
5g5gB-4z3oA:
undetectable		 5g5gA-4z3oA:
14.84
5g5gB-4z3oA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		3 / 3 ALA A1401
ASN A1404
LEU A1405
 None
 0.39A 5i1oC-4z3oA:
undetectable		 5i1oC-4z3oA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
(Streptococcus
pneumoniae) 		3 / 3 ALA A1401
ASN A1404
LEU A1405
 None
 0.35A 5i1pA-4z3oA:
undetectable		 5i1pA-4z3oA:
4.63