SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z42'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 5 HIS C 139
HIS C 224
HIS C 251
HIS C 277
ASP C 365
 NI  C 602 ( 3.0A)
NI  C 601 (-4.7A)
NI  C 601 (-3.3A)
NI  C 601 (-4.6A)
NI  C 602 ( 1.9A)
 0.65A 1e9yB-4z42C:
57.4		 1e9yB-4z42C:
57.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FWE_C_HAEC989_1
(UREASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		6 / 6 HIS C 139
HIS C 141
HIS C 224
HIS C 251
HIS C 277
ASP C 365
 NI  C 602 ( 3.0A)
NI  C 602 (-3.7A)
NI  C 601 (-4.7A)
NI  C 601 (-3.3A)
NI  C 601 (-4.6A)
NI  C 602 ( 1.9A)
 0.68A 1fweC-4z42C:
58.3		 1fweC-4z42C:
59.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		3 / 3 ALA C 133
VAL C  78
TRP C 440
 None
 0.96A 1grmA-4z42C:
undetectable		 1grmA-4z42C:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		3 / 3 ALA C 133
VAL C  78
TRP C 440
 None
 0.96A 1grmB-4z42C:
undetectable		 1grmB-4z42C:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		3 / 3 ASP C 122
LEU C  70
HIS C 128
 None
 0.74A 1qknA-4z42C:
undetectable		 1qknA-4z42C:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 4z42 UREASE SUBUNIT BETA
UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica;
Yersinia
enterocolitica) 		5 / 12 GLY B  39
GLY B  38
ASP C 401
PHE C  29
ASN B  34
 None
 1.19A 1xdsA-4z42B:
undetectable		 1xdsA-4z42B:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 4z42 UREASE SUBUNIT BETA
UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica;
Yersinia
enterocolitica) 		5 / 12 GLY B  39
GLY B  38
ASP C 401
PHE C  29
ASN B  34
 None
 1.16A 1xdsB-4z42B:
undetectable		 1xdsB-4z42B:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 12 LEU C 186
LEU C 512
GLU C 508
GLY C 505
ALA C 500
 None
 1.16A 2bm9C-4z42C:
undetectable		 2bm9C-4z42C:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		3 / 3 THR C 306
PRO C 308
PRO C 305
 None
 0.89A 2d55C-4z42C:
undetectable		 2d55C-4z42C:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 12 SER C 364
SER C 366
ARG C 378
ASN C 375
ALA C 151
 None
 1.46A 2vdmA-4z42C:
undetectable
2vdmB-4z42C:
undetectable		 2vdmA-4z42C:
21.49
2vdmB-4z42C:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		3 / 3 MET C 369
GLU C 225
ASN C 256
 None
 0.93A 3a27A-4z42C:
undetectable		 3a27A-4z42C:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		3 / 3 THR C 278
SER C 360
LYS C 411
 None
 0.74A 3aocC-4z42C:
undetectable		 3aocC-4z42C:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 4z42 UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Yersinia
enterocolitica) 		5 / 12 TYR C  39
ASP C  19
SER C   5
TYR C   9
ILE B  47
 None
 0.94A 3b7pC-4z42C:
undetectable		 3b7pC-4z42C:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 4z42 UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Yersinia
enterocolitica) 		5 / 12 TYR C  39
ASP C  35
SER C   5
TYR C   9
ILE B  47
 None
 1.21A 3b7pC-4z42C:
undetectable		 3b7pC-4z42C:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 8 SER C 249
ALA C 419
PHE C 160
ILE C 136
 None
 0.96A 3bpxA-4z42C:
undetectable
3bpxB-4z42C:
undetectable		 3bpxA-4z42C:
13.95
3bpxB-4z42C:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 12 ILE C 426
THR C 138
VAL C 494
THR C 158
PRO C 416
 None
 1.24A 3dcjA-4z42C:
undetectable
3dcjB-4z42C:
undetectable		 3dcjA-4z42C:
18.01
3dcjB-4z42C:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 5 PRO C 193
VAL C 194
THR C 176
GLY C 162
 None
 1.16A 3elzB-4z42C:
undetectable		 3elzB-4z42C:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 5 PRO C 193
VAL C 194
THR C 176
GLY C 163
 None
 1.18A 3elzB-4z42C:
undetectable		 3elzB-4z42C:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 10 ASP C 365
ILE C 140
GLY C 161
GLY C 162
ILE C 143
 NI  C 602 ( 1.9A)
None
None
None
None
 1.01A 3em4V-4z42C:
undetectable		 3em4V-4z42C:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 12 GLU C  42
GLY C  38
LEU C  36
SER C  43
GLY C 103
 None
 1.06A 3g2oA-4z42C:
undetectable		 3g2oA-4z42C:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 4z42 UREASE SUBUNIT BETA
UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica;
Yersinia
enterocolitica) 		3 / 3 THR B 135
LYS C 101
GLU B 137
 None
 0.97A 3ijdB-4z42B:
undetectable		 3ijdB-4z42B:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 7 GLU C 430
LEU C  82
ASP C  79
ARG C  81
 None
 1.28A 3mbgA-4z42C:
undetectable
3mbgB-4z42C:
undetectable		 3mbgA-4z42C:
12.48
3mbgB-4z42C:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		3 / 3 ASP C  79
GLU C  33
SER C 423
 None
 0.73A 3p2kA-4z42C:
undetectable		 3p2kA-4z42C:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 7 ILE C  30
LEU C  23
THR C  76
ILE C 130
 None
 0.95A 3p50A-4z42C:
undetectable		 3p50A-4z42C:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 7 ILE C  30
LEU C  23
THR C  76
ILE C 130
 None
 0.96A 3p50B-4z42C:
undetectable		 3p50B-4z42C:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 7 ILE C  30
LEU C  23
THR C  76
ILE C 130
 None
 0.97A 3p50C-4z42C:
undetectable		 3p50C-4z42C:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 7 ILE C  30
LEU C  23
THR C  76
ILE C 130
 None
 0.97A 3p50D-4z42C:
undetectable		 3p50D-4z42C:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 12 ASP C 263
ILE C 539
THR C 264
ALA C 547
THR C 545
 None
 1.13A 3ua1A-4z42C:
undetectable		 3ua1A-4z42C:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4z42 UREASE SUBUNIT BETA
(Yersinia
enterocolitica) 		5 / 9 LEU B  83
PHE B  85
VAL B 113
LEU B  95
ALA B  90
 None
 1.48A 3uncA-4z42B:
undetectable		 3uncA-4z42B:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4z42 UREASE SUBUNIT BETA
(Yersinia
enterocolitica) 		5 / 9 LEU B  83
PHE B  85
VAL B 113
LEU B  95
ALA B  90
 None
 1.48A 3uncB-4z42B:
undetectable		 3uncB-4z42B:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 7 HIS C 224
ASP C 253
ARG C 341
HIS C 277
 NI  C 601 (-4.7A)
None
None
NI  C 601 (-4.6A)
 1.49A 3zodA-4z42C:
undetectable		 3zodA-4z42C:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 5 LEU C 327
HIS C 224
GLU C 225
HIS C 251
 None
NI  C 601 (-4.7A)
None
NI  C 601 (-3.3A)
 1.15A 4a7bB-4z42C:
undetectable		 4a7bB-4z42C:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 9 HIS C 139
HIS C 141
GLY C 169
ASN C 171
HIS C 224
 NI  C 602 ( 3.0A)
NI  C 602 (-3.7A)
None
None
NI  C 601 (-4.7A)
 1.25A 4c1hA-4z42C:
undetectable		 4c1hA-4z42C:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		3 / 3 TYR C   9
THR C  16
GLU C 127
 None
 0.82A 4df3A-4z42C:
undetectable		 4df3A-4z42C:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		3 / 3 TYR C   9
THR C  16
GLU C 127
 None
 0.80A 4df3B-4z42C:
undetectable		 4df3B-4z42C:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4H9M_A_HAEA929_1
(UREASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 5 HIS C 139
HIS C 224
HIS C 251
HIS C 277
ASP C 365
 NI  C 602 ( 3.0A)
NI  C 601 (-4.7A)
NI  C 601 (-3.3A)
NI  C 601 (-4.6A)
NI  C 602 ( 1.9A)
 0.70A 4h9mA-4z42C:
54.8		 4h9mA-4z42C:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 8 ASN C 384
ALA C 564
TYR C 569
ARG C 568
 None
 1.00A 4ijiF-4z42C:
undetectable		 4ijiF-4z42C:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 7 ASN C 384
ALA C 564
TYR C 569
ARG C 568
 None
 1.09A 4ijiH-4z42C:
undetectable		 4ijiH-4z42C:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		3 / 3 PRO C 105
ASN C  58
HIS C  60
 None
 0.98A 4ma3H-4z42C:
undetectable
4ma3L-4z42C:
undetectable		 4ma3H-4z42C:
16.90
4ma3L-4z42C:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 4z42 UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Yersinia
enterocolitica) 		5 / 11 ASP C  53
PRO C 105
VAL C 107
GLY C 103
THR B 123
 None
 1.31A 4mmaA-4z42C:
0.0		 4mmaA-4z42C:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 4z42 UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Yersinia
enterocolitica) 		6 / 12 ASN C 104
ASP C 109
LEU B 124
GLY C 110
ASN B  50
GLY C  40
 None
 1.48A 4n09D-4z42C:
2.4		 4n09D-4z42C:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4z42 UREASE SUBUNIT BETA
UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica;
Yersinia
enterocolitica) 		5 / 12 GLY B 119
PHE B 118
THR C  73
GLY C  56
LEU C  51
 None
 1.21A 4n48A-4z42B:
undetectable		 4n48A-4z42B:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 5 ALA C  10
GLY C  14
ASP C 401
ASP C  19
 None
 1.01A 4n48A-4z42C:
undetectable		 4n48A-4z42C:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 11 GLY C 172
ASP C 365
ILE C 140
GLY C 162
ILE C 143
 None
NI  C 602 ( 1.9A)
None
None
None
 1.00A 4njvC-4z42C:
undetectable		 4njvC-4z42C:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 4 LYS C 487
ASN C 459
ASP C 436
ASP C 513
 None
 1.31A 4o1eB-4z42C:
4.9		 4o1eB-4z42C:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 7 HIS C 325
HIS C 251
HIS C 141
ALA C 368
 None
NI  C 601 (-3.3A)
NI  C 602 (-3.7A)
NI  C 602 ( 4.8A)
 0.90A 4p6sA-4z42C:
undetectable		 4p6sA-4z42C:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		3 / 3 PRO C 287
VAL C 548
HIS C 554
 None
 0.69A 4pevC-4z42C:
undetectable		 4pevC-4z42C:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 9 ILE C  91
VAL C  71
GLY C  98
THR C 112
ILE C  85
 None
 1.03A 4r21B-4z42C:
undetectable		 4r21B-4z42C:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		6 / 6 HIS C 139
HIS C 141
HIS C 224
HIS C 251
HIS C 277
ASP C 365
 NI  C 602 ( 3.0A)
NI  C 602 (-3.7A)
NI  C 601 (-4.7A)
NI  C 601 (-3.3A)
NI  C 601 (-4.6A)
NI  C 602 ( 1.9A)
 0.56A 4ubpC-4z42C:
58.0		 4ubpC-4z42C:
57.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4z42 UREASE SUBUNIT GAMMA
(Yersinia
enterocolitica) 		4 / 4 LEU A  16
VAL A  19
GLU A  34
ARG A  23
 None
 0.80A 4ww7A-4z42A:
undetectable		 4ww7A-4z42A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 7 LEU C 317
GLY C 282
GLY C 283
ILE C 289
 None
 0.68A 4yjiA-4z42C:
undetectable		 4yjiA-4z42C:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 12 HIS C 224
HIS C 251
GLY C 283
ASP C 226
LEU C 327
 NI  C 601 (-4.7A)
NI  C 601 (-3.3A)
None
None
None
 1.08A 5eeiA-4z42C:
undetectable		 5eeiA-4z42C:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 12 HIS C 224
HIS C 251
GLY C 283
ASP C 226
LEU C 327
 NI  C 601 (-4.7A)
NI  C 601 (-3.3A)
None
None
None
 1.10A 5eeiB-4z42C:
undetectable		 5eeiB-4z42C:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 8 HIS C 224
GLY C 284
GLY C 283
ASP C 226
HIS C 325
 NI  C 601 (-4.7A)
None
None
None
None
 1.40A 5f8yB-4z42C:
undetectable		 5f8yB-4z42C:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 8 HIS C 224
GLY C 284
GLY C 283
VAL C 250
ASP C 226
 NI  C 601 (-4.7A)
None
None
None
None
 1.44A 5f8yB-4z42C:
undetectable		 5f8yB-4z42C:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 5 HIS C 325
HIS C 224
HIS C 141
ALA C 368
 None
NI  C 601 (-4.7A)
NI  C 602 (-3.7A)
NI  C 602 ( 4.8A)
 1.19A 5i3bB-4z42C:
undetectable		 5i3bB-4z42C:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 5 HIS C 325
HIS C 251
HIS C 141
ALA C 368
 None
NI  C 601 (-3.3A)
NI  C 602 (-3.7A)
NI  C 602 ( 4.8A)
 0.96A 5i3bB-4z42C:
undetectable		 5i3bB-4z42C:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 12 LEU C  70
ILE C  77
VAL C  89
GLY C  90
ILE C  91
 None
 0.70A 5j2tC-4z42C:
2.3		 5j2tC-4z42C:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 4 LEU C 234
ARG C 271
ILE C 273
PHE C 268
 None
 1.20A 5kirB-4z42C:
undetectable		 5kirB-4z42C:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 10 HIS C 141
HIS C 139
HIS C 251
HIS C 224
THR C 174
 NI  C 602 (-3.7A)
NI  C 602 ( 3.0A)
NI  C 601 (-3.3A)
NI  C 601 (-4.7A)
None
 1.13A 5m8nA-4z42C:
undetectable		 5m8nA-4z42C:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 10 HIS C 141
HIS C 139
HIS C 277
HIS C 251
THR C 174
 NI  C 602 (-3.7A)
NI  C 602 ( 3.0A)
NI  C 601 (-4.6A)
NI  C 601 (-3.3A)
None
 1.31A 5m8nA-4z42C:
undetectable		 5m8nA-4z42C:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 10 HIS C 141
HIS C 139
HIS C 251
HIS C 224
THR C 174
 NI  C 602 (-3.7A)
NI  C 602 ( 3.0A)
NI  C 601 (-3.3A)
NI  C 601 (-4.7A)
None
 1.17A 5m8nB-4z42C:
undetectable		 5m8nB-4z42C:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 10 HIS C 141
HIS C 139
HIS C 277
HIS C 251
THR C 174
 NI  C 602 (-3.7A)
NI  C 602 ( 3.0A)
NI  C 601 (-4.6A)
NI  C 601 (-3.3A)
None
 1.42A 5m8nB-4z42C:
undetectable		 5m8nB-4z42C:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		5 / 12 ASP C 263
ILE C 539
THR C 264
ALA C 547
THR C 545
 None
 1.07A 5vcgA-4z42C:
undetectable		 5vcgA-4z42C:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 7 ARG C 407
THR C 536
PRO C 537
PRO C 300
 None
 1.33A 6a4iB-4z42C:
undetectable		 6a4iB-4z42C:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4z42 UREASE SUBUNIT ALPHA
(Yersinia
enterocolitica) 		4 / 7 ASP C  88
GLY C  56
SER C 102
GLY C 103
 None
 0.92A 6ekzA-4z42C:
undetectable		 6ekzA-4z42C:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 4z42 UREASE SUBUNIT BETA
(Yersinia
enterocolitica) 		4 / 7 GLY B  92
LYS B  93
ASN B 142
GLY B 138
 None
 0.88A 6n7fA-4z42B:
undetectable		 6n7fA-4z42B:
18.90