SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 12 LEU A 360
SER A 339
SER A 338
CYH A 217
HIS A 363
 None
 1.27A 1db1A-4z43A:
undetectable		 1db1A-4z43A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 12 GLY A  12
GLY A  17
ALA A 168
LEU A 223
VAL A 187
 FAD  A 601 (-3.2A)
None
None
FAD  A 601 (-3.7A)
FAD  A 601 (-3.8A)
 1.29A 1i9gA-4z43A:
undetectable		 1i9gA-4z43A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 12 LEU A 224
LEU A 223
GLY A 222
GLN A 227
ILE A 215
 None
FAD  A 601 (-3.7A)
None
None
None
 1.39A 1p93A-4z43A:
undetectable		 1p93A-4z43A:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		6 / 11 ILE A  52
ILE A  82
HIS A 101
GLU A 346
PHE A 454
ASN A 459
 None
 0.71A 2aqjA-4z43A:
59.3		 2aqjA-4z43A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		6 / 11 ILE A  52
PRO A  53
ILE A  82
HIS A 101
GLU A 346
ASN A 459
 None
 0.60A 2aqjA-4z43A:
59.3		 2aqjA-4z43A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		6 / 11 ILE A  82
HIS A 101
GLU A 346
PHE A 454
TRP A 455
ASN A 459
 None
 0.51A 2aqjA-4z43A:
59.3		 2aqjA-4z43A:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 10 ILE A  52
ILE A  82
HIS A 101
PHE A 454
ASN A 459
 None
 0.70A 2jkcA-4z43A:
59.3		 2jkcA-4z43A:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 10 ILE A  52
PRO A  53
ILE A  82
HIS A 101
ASN A 459
 None
 0.59A 2jkcA-4z43A:
59.3		 2jkcA-4z43A:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 10 ILE A  82
HIS A 101
PHE A 454
TRP A 455
ASN A 459
 None
 0.53A 2jkcA-4z43A:
59.3		 2jkcA-4z43A:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		8 / 12 ILE A  52
LYS A  79
ILE A  82
HIS A 101
PHE A 103
GLU A 346
PHE A 454
ASN A 459
 None
 0.81A 2oa1A-4z43A:
52.9		 2oa1A-4z43A:
53.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		8 / 12 ILE A  52
PRO A  53
LYS A  79
ILE A  82
HIS A 101
PHE A 103
GLU A 346
ASN A 459
 None
 0.66A 2oa1A-4z43A:
52.9		 2oa1A-4z43A:
53.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		7 / 12 LYS A  79
ILE A  82
HIS A 101
GLU A 346
PHE A 454
TRP A 455
ASN A 459
 None
 0.71A 2oa1A-4z43A:
52.9		 2oa1A-4z43A:
53.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OA1_A_TRPA2003_0
(TRYPTOPHAN
HALOGENASE)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		7 / 12 ILE A  52
ILE A  82
HIS A 101
PHE A 103
GLU A 346
PHE A 454
ASN A 459
 None
 0.85A 2oa1B-4z43A:
52.7		 2oa1B-4z43A:
53.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OA1_A_TRPA2003_0
(TRYPTOPHAN
HALOGENASE)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		7 / 12 ILE A  52
PRO A  53
ILE A  82
HIS A 101
PHE A 103
GLU A 346
ASN A 459
 None
 0.72A 2oa1B-4z43A:
52.7		 2oa1B-4z43A:
53.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OA1_A_TRPA2003_0
(TRYPTOPHAN
HALOGENASE)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		6 / 12 ILE A  82
HIS A 101
GLU A 346
PHE A 454
TRP A 455
ASN A 459
 None
 0.59A 2oa1B-4z43A:
52.7		 2oa1B-4z43A:
53.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		4 / 7 GLY A  12
GLY A  13
VAL A 187
SER A 218
 FAD  A 601 (-3.2A)
FAD  A 601 (-3.3A)
FAD  A 601 (-3.8A)
FAD  A 601 (-4.9A)
 0.29A 2oa1B-4z43A:
52.7		 2oa1B-4z43A:
53.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		4 / 7 GLY A  12
VAL A 187
SER A 218
LEU A 223
 FAD  A 601 (-3.2A)
FAD  A 601 (-3.8A)
FAD  A 601 (-4.9A)
FAD  A 601 (-3.7A)
 0.51A 2oa1B-4z43A:
52.7		 2oa1B-4z43A:
53.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		4 / 6 VAL A  47
PHE A 162
THR A 263
TRP A 274
 FAD  A 601 (-4.5A)
None
None
None
 1.41A 2q6oB-4z43A:
undetectable		 2q6oB-4z43A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		6 / 12 LEU A  55
GLY A  48
ASN A 315
GLY A  46
GLY A 349
ILE A  45
 None
FAD  A 601 (-3.4A)
None
None
FAD  A 601 ( 3.6A)
FAD  A 601 (-3.7A)
 1.28A 3ku1A-4z43A:
undetectable		 3ku1A-4z43A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 11 VAL A 246
PHE A 319
PHE A 341
GLY A  48
ILE A 276
 None
None
FAD  A 601 (-4.4A)
FAD  A 601 (-3.4A)
None
 1.33A 3owxA-4z43A:
undetectable
3owxB-4z43A:
undetectable		 3owxA-4z43A:
18.22
3owxB-4z43A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		3 / 3 ASP A 169
ARG A 182
LYS A 172
 None
 1.23A 3wipG-4z43A:
undetectable		 3wipG-4z43A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		4 / 5 ILE A 381
ALA A 355
HIS A 383
MET A 384
 None
 1.07A 4ac9B-4z43A:
undetectable
4ac9C-4z43A:
undetectable		 4ac9B-4z43A:
20.80
4ac9C-4z43A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		4 / 5 ILE A 381
ALA A 355
HIS A 383
MET A 384
 None
 1.08A 4acaB-4z43A:
undetectable
4acaC-4z43A:
undetectable		 4acaB-4z43A:
20.80
4acaC-4z43A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		4 / 7 ASP A 243
THR A 293
ASN A 410
LEU A 414
 None
 1.07A 4ib4A-4z43A:
undetectable		 4ib4A-4z43A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 11 GLY A 285
ALA A 300
VAL A 246
GLN A 316
PRO A 344
 None
None
None
None
FAD  A 601 ( 4.3A)
 1.33A 4j4vA-4z43A:
undetectable		 4j4vA-4z43A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 10 GLY A 285
ALA A 300
VAL A 246
GLN A 316
PRO A 344
 None
None
None
None
FAD  A 601 ( 4.3A)
 1.36A 4j4vB-4z43A:
undetectable		 4j4vB-4z43A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 11 GLY A 285
ALA A 300
VAL A 246
GLN A 316
PRO A 344
 None
None
None
None
FAD  A 601 ( 4.3A)
 1.38A 4j4vD-4z43A:
undetectable
4j4vE-4z43A:
undetectable		 4j4vD-4z43A:
19.34
4j4vE-4z43A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_E_SVRE301_1
(NUCLEOCAPSID PROTEIN)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 10 GLY A 285
ALA A 300
VAL A 246
GLN A 316
PRO A 344
 None
None
None
None
FAD  A 601 ( 4.3A)
 1.35A 4j4vA-4z43A:
undetectable
4j4vE-4z43A:
undetectable		 4j4vA-4z43A:
19.34
4j4vE-4z43A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 12 ILE A  52
CYH A 340
VAL A 392
HIS A 395
HIS A 101
 None
 1.48A 4rujA-4z43A:
undetectable		 4rujA-4z43A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 12 LEU A 201
LEU A 224
ARG A 191
LEU A 192
ILE A 198
 None
 0.86A 4x1fA-4z43A:
undetectable		 4x1fA-4z43A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 12 LEU A 201
LEU A 224
ARG A 191
LEU A 192
ILE A 198
 None
 0.89A 4x1gA-4z43A:
undetectable		 4x1gA-4z43A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		4 / 8 ASP A 375
ASN A 378
ALA A 379
VAL A 382
 None
 0.49A 4zbqA-4z43A:
undetectable		 4zbqA-4z43A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 11 VAL A 246
PHE A 319
PHE A 341
GLY A  48
ILE A 276
 None
None
FAD  A 601 (-4.4A)
FAD  A 601 (-3.4A)
None
 1.42A 4zvmA-4z43A:
undetectable
4zvmB-4z43A:
2.1		 4zvmA-4z43A:
18.22
4zvmB-4z43A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		4 / 8 SER A 248
ALA A 249
PRO A 313
LEU A 308
 None
 1.13A 5dzkF-4z43A:
undetectable
5dzkT-4z43A:
undetectable		 5dzkF-4z43A:
18.55
5dzkT-4z43A:
0.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		3 / 3 ARG A 195
ASN A 330
ASP A 375
 None
 0.66A 5gwxA-4z43A:
2.4		 5gwxA-4z43A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 12 PHE A 377
LEU A 357
ALA A 356
SER A 339
ILE A 215
 None
 1.37A 5ljbA-4z43A:
undetectable		 5ljbA-4z43A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 11 ASP A 403
PRO A  91
ALA A 298
TYR A 286
ALA A 245
 None
None
None
None
FAD  A 601 ( 3.7A)
 1.46A 6bm5A-4z43A:
undetectable		 6bm5A-4z43A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		4 / 6 GLY A 111
ASP A 110
SER A 484
ARG A 481
 None
 1.18A 6dwdA-4z43A:
undetectable
6dwdC-4z43A:
undetectable		 6dwdA-4z43A:
20.62
6dwdC-4z43A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 10 GLY A  48
GLY A  46
GLU A  49
ASP A 163
ILE A 350
 FAD  A 601 (-3.4A)
None
None
None
FAD  A 601 (-3.2A)
 1.20A 6exiA-4z43A:
2.6		 6exiA-4z43A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA
(Pseudomonas
fluorescens) 		5 / 12 GLY A  48
GLY A  46
GLU A  49
ASP A 163
ILE A 350
 FAD  A 601 (-3.4A)
None
None
None
FAD  A 601 (-3.2A)
 1.21A 6exiC-4z43A:
2.2
6exiD-4z43A:
undetectable		 6exiC-4z43A:
9.30
6exiD-4z43A:
9.30